Neuromuscular electrical stimulation improves GLUT-4 and morphological characteristics of skeletal muscle in rats with heart failure

Aim: Changes in skeletal muscle morphology and metabolism are associated with limited functional capacity in heart failure, which can be attenuated by neuromuscular electrical stimulation (ES). The purpose of the present study was to analyse the effects of ES upon GLUT-4 protein content, fibre struc...

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Bibliographic Details
Published in:	Acta Physiologica Vol. 201; no. 2; pp. 265 - 273
Main Authors:	de Leon, E.B, Bortoluzzi, A, Rucatti, A, Nunes, R.B, Saur, L, Rodrigues, M, Oliveira, U, Alves-Wagner, A.B, Xavier, L.L, Machado, U.F, Schaan, B.D, Dall'Ago, P
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-02-2011 Wiley-Blackwell
Subjects:	Animals Biological and medical sciences Electric Stimulation Therapy electrical stimulation Fundamental and applied biological sciences. Psychology Glucose Transporter Type 4 - metabolism GLUT-4 Heart Failure - complications Heart Failure - physiopathology Hemodynamics Male Muscle, Skeletal - blood supply Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Diseases - etiology Muscular Diseases - metabolism Muscular Diseases - pathology Muscular Diseases - therapy myocardial infarction Myocardial Infarction - complications Rats Rats, Wistar skeletal muscle Vertebrates: anatomy and physiology, studies on body, several organs or systems Myocardial infarction Heart failure electrical stimulation Rat Electrical stimulus Rodentia Cardiovascular disease Striated muscle Coronary heart disease Myocardial disease Vertebrata Mammalia GLUT-4 skeletal muscle
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Summary:	Aim: Changes in skeletal muscle morphology and metabolism are associated with limited functional capacity in heart failure, which can be attenuated by neuromuscular electrical stimulation (ES). The purpose of the present study was to analyse the effects of ES upon GLUT-4 protein content, fibre structure and vessel density of the skeletal muscle in a rat model of HF subsequent to myocardial infarction. Methods: Forty-four male Wistar rats were assigned to one of four groups: sham (S), sham submitted to ES (S+ES), heart failure (HF) and heart failure submitted to ES (HF+ES). The rats in the ES groups were submitted to ES of the left leg during 20 days (2.5 kHz, once a day, 30 min, duty cycle 50%- 15 s contraction/15 s rest). After this period, the left tibialis anterior muscle was collected from all the rats for analysis. Results: HF+ES rats showed lower values of lung congestion when compared with HF rats (P = 0.0001). Although muscle weight was lower in HF rats than in the S group, thus indicating hypotrophy, 20 days of ES led to their recovery (P < 0.0001). In both groups submitted to ES, there was an increase in muscle vessel density (P < 0.04). Additionally, heart failure determined a 49% reduction in GLUT-4 protein content (P < 0.03), which was recovered by ES (P < 0.01). Conclusion: In heart failure, ES improves morphological changes and raises GLUT-4 content in skeletal muscle.
Bibliography:	http://dx.doi.org/10.1111/j.1748-1716.2010.02176.x istex:E64EDCACAA7786D97ABB56F5536C30D9C3D8CF4F ArticleID:APHA2176 ark:/67375/WNG-62F7JJ50-G ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1748-1708 1748-1716
DOI:	10.1111/j.1748-1716.2010.02176.x