Search Results - "de Lange, Elizabeth C.M"

Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets by Puris, Elena, Gynther, Mikko, de Lange, Elizabeth C.M, Auriola, Seppo, Hammarlund-Udenaes, Margareta, Huttunen, Kristiina M, Loryan, Irena

“…l-Type amino acid transporter 1 (LAT1), selectively expressed at the blood–brain barrier (BBB) and brain parenchymal cells, mediates brain delivery of drugs…”
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In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant by de Witte, Wilhelmus E.A, Danhof, Meindert, van der Graaf, Piet H, de Lange, Elizabeth C.M

“…It is generally accepted that, in conjunction with pharmacokinetics, the first-order rate constant of target dissociation is a major determinant of the time…”
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Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model by Puris, Elena, Auriola, Seppo, Petralla, Sabrina, Hartman, Robin, Gynther, Mikko, de Lange, Elizabeth C.M., Fricker, Gert

“…There is growing evidence that membrane transporters expressed at the blood-brain barrier (BBB) and brain parenchymal cells play an important role in…”
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P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice by Sills, Graeme J., Kwan, Patrick, Butler, Elaine, de Lange, Elizabeth C.M., van den Berg, Dirk-Jan, Brodie, Martin J.

“…Evidence suggests that the efflux transporter P-glycoprotein (P-gp) may play a facilitatory role in refractory epilepsy by limiting the brain access of…”
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The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions by Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C.M.

“…Purpose We have developed a 3D brain unit network model to understand the spatial-temporal distribution of a drug within the brain under different (normal and…”
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High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: Application to pharmacokinetic/pharmacodynamic studies in rats by Groenendaal, Dorien, Blom-Roosemalen, Margret C.M., Danhof, Meindert, Lange, Elizabeth C.M. de

“…A rapid and sensitive assay for quantification of nalbuphine, butorphanol and morphine in blood (50 μL) and brain microdialysate (∼40 μL) samples was…”
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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research by Danhof, Meindert, de Lange, Elizabeth C.M, Della Pasqua, Oscar E, Ploeger, Bart A, Voskuyl, Rob A

“…The use of pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research is a promising approach that provides better understanding of drug…”
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Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals by Qin, Tian, Prins, Samantha, Groeneveld, Geert Jan, Van Westen, Gerard, de Vries, Helga E, Wong, Yin Cheong, Bischoff, Luc J M, de Lange, Elizabeth C M

“…To diagnose and treat early-stage (preclinical) Alzheimer's disease (AD) patients, we need body-fluid-based biomarkers that reflect the processes that occur in…”
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Prediction of methotrexate CNS distribution in different species – Influence of disease conditions by Westerhout, Joost, van den Berg, Dirk-Jan, Hartman, Robin, Danhof, Meindert, de Lange, Elizabeth C.M.

“…Children and adults with malignant diseases have a high risk of prevalence of the tumor in the central nervous system (CNS). As prophylaxis treatment…”
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Effects of daily L-dopa administration on learning and brain structure in older adults undergoing cognitive training: a randomised clinical trial by Lebedev, Alexander V., Nilsson, Jonna, Lindström, Joanna, Fredborg, William, Akenine, Ulrika, Hillilä, Carolina, Andersen, Pia, Spulber, Gabriela, de Lange, Elizabeth C. M., van den Berg, Dirk-Jan, Kivipelto, Miia, Lövdén, Martin

“…Cognitive aging creates major individual and societal burden, motivating search for treatment and preventive care strategies. Behavioural interventions can…”
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T lymphocytes impair P-glycoprotein function during neuroinflammation by Kooij, Gijs, van Horssen, Jack, de Lange, Elizabeth C.M, Reijerkerk, Arie, van der Pol, Susanne M.A, van het Hof, Bert, Drexhage, Joost, Vennegoor, Anke, Killestein, Joep, Scheffer, George, Oerlemans, Ruud, Scheper, Rik, van der Valk, Paul, Dijkstra, Christine D, de Vries, Helga E

“…Abstract The ATP-binding cassette (ABC) transporter P-glycoprotein (P-gp; ABCB1) is highly expressed at the blood–brain barrier (BBB). P-gp actively secretes…”
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Methodological issues in microdialysis sampling for pharmacokinetic studies by de Lange, Elizabeth C.M., de Boer, A.G., Breimer, Douwe D.

“…Microdialysis is an in vivo technique that permits monitoring of local concentrations of drugs and metabolites at specific sites in the body. Microdialysis has…”
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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier by Wijnholds, J, deLange, E C, Scheffer, G L, van den Berg, D J, Mol, C A, van der Valk, M, Schinkel, A H, Scheper, R J, Breimer, D D, Borst, P

“…Multidrug resistance protein 1 (MRP1) is a transporter protein that helps to protect normal cells and tumor cells against the influx of certain xenobiotics. We…”
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Blood‐Based Biomarkers of Quinpirole Pharmacology: Cluster‐Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain by Brink, Willem J., Hartman, Robin, Berg, Dirk‐Jan, Flik, Gunnar, Gonzalez‐Amoros, Belén, Koopman, Nanda, Elassais‐Schaap, Jeroen, Graaf, Piet Hein, Hankemeier, Thomas, Lange, Elizabeth C.M.

“…A key challenge in the development of central nervous system drugs is the availability of drug target specific blood‐based biomarkers. As a new approach, we…”
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Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease by Ravenstijn, Paulien Gm, Drenth, Henk-Jan, O'Neill, Michael J, Danhof, Meindert, de Lange, Elizabeth Cm

“…Changes in blood-brain barrier (BBB) functionality have been implicated in Parkinson's disease. This study aimed to investigate BBB transport of L-DOPA…”
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The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments by Ravenstijn, Paulien G.M., Merlini, Mario, Hameetman, Marjolijn, Murray, Tracey K., Ward, Mark A., Lewis, Hywel, Ball, Gareth, Mottart, Cathy, de Ville de Goyet, Christine, Lemarchand, Thomas, van Belle, Kristel, O'Neill, Michael J., Danhof, Meindert, de Lange, Elizabeth C.M.

“…In search for a suitable rat model to study potentially affected blood-brain barrier (BBB) transport mechanisms in the course of Parkinsons disease (PD)…”
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Summary data of potency and parameter information from semi-mechanistic PKPD modeling of prolactin release following administration of the dopamine D2 receptor antagonists risperidone, paliperidone and remoxipride in rats by Taneja, Amit, Vermeulen, An, Huntjens, Dymphy R.H., Danhof, Meindert, De Lange, Elizabeth C.M., Proost, Johannes H.

“…We provide the reader with relevant data related to our recently published paper, comparing two mathematical models to describe prolactin turnover in rats…”
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Understanding Drug Delivery to the Brain Using Liposome-Based Strategies: Studies that Provide Mechanistic Insights Are Essential by Juhairiyah, Firda, de Lange, Elizabeth C. M.

“…Brain drug delivery may be restricted by the blood-brain barrier (BBB), and enhancement by liposome-based drug delivery strategies has been investigated. As…”
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Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring by van Oostveen, Wieke M, de Lange, Elizabeth C M

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting many individuals worldwide with no effective treatment to date. AD is…”
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Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference? by Hu, Yang, Gaillard, Pieter J., de Lange, Elizabeth C.M., Hammarlund-Udenaes, Margareta

“…[Display omitted] The purpose of this study was to quantitatively investigate how conjugation of GSH to different liposomal formulations influence the brain…”
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