Search Results - "de Lange, Elizabeth C. M"

Status of Metabolomic Measurement for Insights in Alzheimer's Disease Progression-What Is Missing? by Yin, Chunyuan, Harms, Amy C, Hankemeier, Thomas, Kindt, Alida, de Lange, Elizabeth C M

“…Alzheimer's disease (AD) is an aging-related neurodegenerative disease, leading to the progressive loss of memory and other cognitive functions. As there is…”
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The implications of target saturation for the use of drug–target residence time by de Witte, Wilhelmus E. A., Danhof, Meindert, van der Graaf, Piet H., de Lange, Elizabeth C. M.

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Revisiting Cerebrospinal Fluid Flow Direction and Rate in Physiologically Based Pharmacokinetic Model by Hirasawa, Makoto, de Lange, Elizabeth C. M

“…The bidirectional pulsatile movement of cerebrospinal fluid (CSF), instead of the traditionally believed unidirectional and constant CSF circulation, has been…”
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Revisiting atenolol as a low passive permeability marker by Chen, Xiaomei, Slättengren, Tim, de Lange, Elizabeth C M, Smith, David E, Hammarlund-Udenaes, Margareta

“…Atenolol, a hydrophilic beta blocker, has been used as a model drug for studying passive permeability of biological membranes such as the blood-brain barrier…”
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The need for mathematical modelling of spatial drug distribution within the brain by Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C M

“…The blood brain barrier (BBB) is the main barrier that separates the blood from the brain. Because of the BBB, the drug concentration-time profile in the brain…”
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Utility of CSF in translational neuroscience by de Lange, Elizabeth C. M.

“…Human cerebrospinal fluid (CSF) sampling is of high value as the only general applicable methodology to obtain information on free drug concentrations in…”
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A 3D brain unit model to further improve prediction of local drug distribution within the brain by Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C. M

“…The development of drugs targeting the brain still faces a high failure rate. One of the reasons is a lack of quantitative understanding of the complex…”
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Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human by Wong, Yin Cheong, Centanni, Maddalena, Lange, Elizabeth C. M.

“…Receptor occupancy (RO) is a translational biomarker for assessing drug efficacy and safety. We aimed to apply a physiologically based pharmacokinetic (PBPK)…”
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A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations by Yamamoto, Yumi, Välitalo, Pyry A., van den Berg, Dirk-Jan, Hartman, Robin, van den Brink, Willem, Wong, Yin Cheong, Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Bakshi, Suruchi, Aranzana-Climent, Vincent, Marchand, Sandrine, Dahyot-Fizelier, Claire, Couet, William, Danhof, Meindert, van Hasselt, Johan G. C., de Lange, Elizabeth C. M.

“…Purpose Predicting target site drug concentration in the brain is of key importance for the successful development of drugs acting on the central nervous…”
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Next-generation biomarker discovery in Alzheimer's disease using metabolomics - from animal to human studies by Hurtado, Marina Ollé, Kohler, Isabelle, de Lange, Elizabeth CM

“…Alzheimer's disease (AD) is a complex disease driven mainly by neuronal loss due to accumulation of intracellular neurofibrillary tangles and amyloid β…”
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Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring by van Oostveen, Wieke M, de Lange, Elizabeth C M

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting many individuals worldwide with no effective treatment to date. AD is…”
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Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis by DANHOF, Meindert, DE JONGH, Joost, DE LANGE, Elizabeth C. M, PASQUA, Oscar Della, PLOEGER, Bart A, VOSKUYL, Rob A

“…Mechanism-based PK-PD models differ from conventional PK-PD models in that they contain specific expressions to characterize, in a quantitative manner,…”
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The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure by Zhang, Mengxu, Rottschäfer, Vivi, C M de Lange, Elizabeth

“…Drug metabolism is one of the critical determinants of drug disposition throughout the body. While traditionally associated with the liver, recent research has…”
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The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology by Hirasawa, Makoto, Saleh, Mohammed A. A., de Lange, Elizabeth C. M.

“…Micrometastatic brain tumor cells, which cause recurrence of malignant brain tumors, are often protected by the intact blood–brain barrier (BBB). Therefore, it…”
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Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans by Ruigrok, Mitchel J. R., de Lange, Elizabeth C. M.

“…To investigate the potential added value of intranasal drug administration, preclinical studies to date have typically used the area under the curve (AUC) in…”
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Non‐linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix by Budda, Divakar, Gülave, Berfin, Hasselt, J. G. Coen, Lange, Elizabeth C. M.

“…Background and Purpose Morphine is important for treatment of acute and chronic pain. However, there is high interpatient variability and often inadequate pain…”
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Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations by Yamamoto, Yumi, Danhof, Meindert, de Lange, Elizabeth C. M.

“…Despite the enormous research efforts that have been put into the development of central nervous system (CNS) drugs, the success rate in this area is still…”
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Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice by Saleh, Mohammed A. A., Gülave, Berfin, Campagne, Olivia, Stewart, Clinton F., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.

“…Introduction The unbound brain extracelullar fluid (brain ECF ) to plasma steady state partition coefficient, K p,uu,BBB , values provide steady-state…”
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Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model by Saleh, Mohammed A. A., Bloemberg, Julia S., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.

“…Background Very little knowledge exists on the impact of Alzheimer’s disease on the CNS target site pharmacokinetics (PK). Aim To predict the CNS PK of…”
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Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology by Kok, Frédérique K, van Leerdam, Suzanne L, de Lange, Elizabeth C M

“…Alzheimer's disease (AD) is the most common form of dementia and typically characterized by the accumulation of amyloid-β plaques and tau tangles…”
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