Search Results - "de Lange, C."

Invited review: Amino acid bioavailability and digestibility in pig feed ingredients: Terminology and application by Stein, H.H, Sève, B, Fuller, M.F, Moughan, P.J, de Lange, C.F.M

“…In this review, the terminology that is used to describe the bioavailability and ileal digestibility of AA in pig feed ingredients is defined. Aspects of the…”
Get full text

Status of Metabolomic Measurement for Insights in Alzheimer's Disease Progression-What Is Missing? by Yin, Chunyuan, Harms, Amy C, Hankemeier, Thomas, Kindt, Alida, de Lange, Elizabeth C M

“…Alzheimer's disease (AD) is an aging-related neurodegenerative disease, leading to the progressive loss of memory and other cognitive functions. As there is…”
Get full text

The need for mathematical modelling of spatial drug distribution within the brain by Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C M

“…The blood brain barrier (BBB) is the main barrier that separates the blood from the brain. Because of the BBB, the drug concentration-time profile in the brain…”
Get full text

Multimodal prehabilitation to reduce the incidence of delirium and other adverse events in elderly patients undergoing elective major abdominal surgery: An uncontrolled before-and-after study by Janssen, T L, Steyerberg, E W, Langenberg, J C M, de Lepper, C C H A van Hoof, Wielders, D, Seerden, T C J, de Lange, D C, Wijsman, J H, Ho, G H, Gobardhan, P D, van Alphen, R, van der Laan, L

“…Delirium is a common and serious complication in elderly patients undergoing major abdominal surgery, with significant adverse outcomes. Successful strategies…”
Get full text

Standardized ileal digestible amino acids and digestible energy contents in high-protein distiller's dried grains with solubles fed to growing pigs by Rho, Y, Zhu, C, Kiarie, E, de Lange, C F M

“…Chemical composition and, therefore, potential nutritive value of corn distiller's dried grains with solubles (DDGS) is constantly evolving as the ethanol…”
Get full text

Utility of CSF in translational neuroscience by de Lange, Elizabeth C. M.

“…Human cerebrospinal fluid (CSF) sampling is of high value as the only general applicable methodology to obtain information on free drug concentrations in…”
Get full text

A 3D brain unit model to further improve prediction of local drug distribution within the brain by Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C. M

“…The development of drugs targeting the brain still faces a high failure rate. One of the reasons is a lack of quantitative understanding of the complex…”
Get full text

The implications of target saturation for the use of drug–target residence time by de Witte, Wilhelmus E. A., Danhof, Meindert, van der Graaf, Piet H., de Lange, Elizabeth C. M.

Get full text

Impact of feeding reduced crude protein diets to lactating sows on nitrogen utilization by Huber, L, de Lange, C F M, Krogh, U, Chamberlin, D, Trottier, N L

“…Forty lactating multiparous Yorkshire sows were used to test the hypothesis that reducing dietary CP and supplementing with crystalline amino acids (CAA)…”
Get full text

Revisiting Cerebrospinal Fluid Flow Direction and Rate in Physiologically Based Pharmacokinetic Model by Hirasawa, Makoto, de Lange, Elizabeth C. M

“…The bidirectional pulsatile movement of cerebrospinal fluid (CSF), instead of the traditionally believed unidirectional and constant CSF circulation, has been…”
Get full text

Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: Issues and recommendations by van den Heuvel, Martijn P., de Lange, Siemon C., Zalesky, Andrew, Seguin, Caio, Yeo, B.T. Thomas, Schmidt, Ruben

“…Graph theoretical analysis has become an important tool in the examination of brain dysconnectivity in neurological and psychiatric brain disorders. A common…”
Get full text

Immune system stimulation increases the optimal dietary methionine to methionine plus cysteine ratio in growing pigs by Litvak, N, Rakhshandeh, A, Htoo, J K, de Lange, C F M

“…Chronic subclinical levels of disease occur frequently in intensive swine production and compromise nutrient use efficiency. Feeding additional Met plus Cys…”
Get full text

Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human by Wong, Yin Cheong, Centanni, Maddalena, Lange, Elizabeth C. M.

“…Receptor occupancy (RO) is a translational biomarker for assessing drug efficacy and safety. We aimed to apply a physiologically based pharmacokinetic (PBPK)…”
Get full text

Enzyme supplementation to improve the nutritional value of fibrous feed ingredients in swine diets fed in dry or liquid form by Moran, K, de Lange, C F M, Ferket, P, Fellner, V, Wilcock, P, van Heugten, E

“…This study evaluated the effect of xylanase supplementation (with or without), feeding method (dry or liquid), and feedstuff (corn distiller's dried grains…”
Get full text

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations by Yamamoto, Yumi, Välitalo, Pyry A., van den Berg, Dirk-Jan, Hartman, Robin, van den Brink, Willem, Wong, Yin Cheong, Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Bakshi, Suruchi, Aranzana-Climent, Vincent, Marchand, Sandrine, Dahyot-Fizelier, Claire, Couet, William, Danhof, Meindert, van Hasselt, Johan G. C., de Lange, Elizabeth C. M.

“…Purpose Predicting target site drug concentration in the brain is of key importance for the successful development of drugs acting on the central nervous…”
Get full text

Improving the Prediction of Local Drug Distribution Profiles in the Brain with a New 2D Mathematical Model by Vendel, E., Rottschäfer, V., de Lange, E. C. M.

“…The development of drugs that target the brain is very challenging. A quantitative understanding is needed of the complex processes that govern the…”
Get full text

Replacing dietary nonessential amino acids with ammonia nitrogen does not alter amino acid profile of deposited protein in the carcass of growing pigs fed a diet deficient in nonessential amino acid nitrogen by Mansilla, W D, Htoo, J K, de Lange, C F M

“…Amino acid usage for protein retention, and, consequently, the AA profile of retained protein, is the main factor for determining AA requirements in growing…”
Get full text

Nitrogen from ammonia is as efficient as that from free amino acids or protein for improving growth performance of pigs fed diets deficient in nonessential amino acid nitrogen by Mansilla, W D, Htoo, J K, de Lange, C F M

“…Inclusion of NPN in diets may compensate the deficient supply of nonessential AA (NEAA) in very low CP levels. To assess this, 2 studies were conducted to…”
Get full text

SID lysine requirement of immunologically and physically castrated male pigs during the grower, early and late finisher periods by Elsbernd, A J, de Lange, C F M, Stalder, K J, Karriker, L A, Patience, J F

“…The main objective of this experiment was to determine the standardized ileal digestible (SID) Lys requirement of immunologically castrated (IC) and physically…”
Get full text

Effects of steeped or fermented distillers dried grains with solubles on growth performance in weanling pigs by Wiseman, M, McBride, B, Li, J, Wey, D, Zhu, J, de Lange, C F M

“…Coproduct feeding value may be improved by enzyme and microbial inoculant treatment in liquid diets. Three experiments were conducted to assess growth…”
Get full text