Search Results - "de Laat, Melody"

The cresty neck score is an independent predictor of insulin dysregulation in ponies by Fitzgerald, Danielle M, Anderson, Stephen T, Sillence, Martin N, de Laat, Melody A

“…Generalized obesity, regional adiposity, hyperinsulinemia and hypertriglyceridemia are all potential indicators of equine metabolic syndrome (EMS). This study…”
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Effects of an anti-IGF-1 receptor monoclonal antibody on laminitis induced by prolonged hyperinsulinaemia in Standardbred horses by Rahnama, Samira, Vathsangam, Niveditha, Spence, Robert, Medina-Torres, Carlos E, Pollitt, Christopher C, de Laat, Melody A, Bailey, Simon R, Sillence, Martin N

“…Currently, there are no registered veterinary drugs for the treatment of endocrinopathic equine laminitis, and although this form of the disease is known to be…”
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An investigation of the equine epidermal growth factor system during hyperinsulinemic laminitis by de Laat, Melody A, Spence, Robert J, Sillence, Martin N, Pollitt, Christopher C

“…Equine laminitis is a disease of the digital epidermal lamellae typified by epidermal cell proliferation and structural collapse. Most commonly the disease is…”
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Evidence for dopamine production and distribution of dopamine D2 receptors in the equine gastrointestinal mucosa and pancreas by Galinelli, Nicolas C, Bamford, Nicholas J, de Laat, Melody A, Sillence, Martin N, Harris, Patricia A, Bailey, Simon R

“…Insulin dysregulation in horses is characterised by hyperinsulinaemia and/or tissue insulin resistance and is associated with increased risk of laminitis…”
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Phenotypic, hormonal, and clinical characteristics of equine endocrinopathic laminitis by Laat, Melody A., Sillence, Martin N., Reiche, Dania B.

“…Background Equine endocrinopathic laminitis is common and can be associated with an underlying endocrinopathy, such as equine metabolic syndrome (EMS),…”
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Sweet taste receptor inhibitors: Potential treatment for equine insulin dysregulation by de Laat, Melody Anne, Kheder, Murad Hasan, Pollitt, Christopher Charles, Sillence, Martin Nicholas

“…Hyperinsulinemia is a major risk factor for equine laminitis, a debilitating and painful foot condition. Sweet taste receptor (T1R2/3) inhibitors have been…”
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Reining in equine metabolic syndrome: A gluttony of challenges by de Laat, Melody A.

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The effect of different grazing conditions on the insulin and incretin response to the oral glucose test in ponies by Fitzgerald, Danielle M, Pollitt, Christopher C, Walsh, Donald M, Sillence, Martin N, de Laat, Melody A

“…The oral glucose test (OGT) is a useful tool for diagnosing insulin dysregulation (ID) and is somewhat repeatable in ponies under consistent management. This…”
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Equine metabolic syndrome: Role of the enteroinsular axis in the insulin response to oral carbohydrate by de Laat, Melody A., Fitzgerald, Danielle M.

“…Equine insulin dysregulation (ID) comprises amplified insulin responses to oral carbohydrates or insulin resistance, or both, which leads to sustained or…”
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Equine glucagon-like peptide-1 receptor physiology by Kheder, Murad H, Bailey, Simon R, Dudley, Kevin J, Sillence, Martin N, de Laat, Melody A

“…Equine metabolic syndrome (EMS) is associated with insulin dysregulation, which often manifests as post-prandial hyperinsulinemia. Circulating concentrations…”
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Differential Proteomic Expression of Equine Cardiac and Lamellar Tissue During Insulin-Induced Laminitis by Campolo, Allison, Frantz, Matthew W., de Laat, Melody A., Hartson, Steven D., Furr, Martin O., Lacombe, Véronique A.

“…Endocrinopathic laminitis is pathologically similar to the multi-organ dysfunction and peripheral neuropathy found in human patients with metabolic syndrome…”
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The sodium-glucose co-transporter 2 inhibitor velagliflozin reduces hyperinsulinemia and prevents laminitis in insulin-dysregulated ponies by Meier, Alexandra, Reiche, Dania, de Laat, Melody, Pollitt, Christopher, Walsh, Donald, Sillence, Martin

“…There are no registered veterinary drugs for treating insulin dysregulation and preventing insulin-associated laminitis in horses. Velagliflozin is a…”
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A glucagon-like peptide-1 receptor antagonist reduces the insulin response to a glycemic meal in ponies by de Laat, Melody A, Fitzgerald, Danielle M, Harris, Patricia A, Bailey, Simon R

“…Abstract High plasma concentrations of insulin can cause acute laminitis. Ponies and horses with insulin dysregulation (ID) exhibit marked hyperinsulinemia in…”
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Associations between feeding and glucagon‐like peptide‐2 in healthy ponies by Sibthorpe, Poppy E. M., Fitzgerald, Danielle M., Sillence, Martin N., Laat, Melody A.

“…Background Gastrointestinal peptides, such as glucagon‐like peptide‐2 (GLP‐2), could play a direct role in the development of equine hyperinsulinaemia…”
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A starch-rich treat affects enteroinsular responses in ponies by Sibthorpe, Poppy E. M., Fitzgerald, Danielle M., Chen, Lan, Sillence, Martin N., de Laat, Melody A.

“…Abstract OBJECTIVE To determine the effect of a starch-rich treat, added to the daily diet of ponies for 10 days, on enteroinsular responses to meal…”
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Incidence and risk factors for recurrence of endocrinopathic laminitis in horses by Laat, Melody A., Reiche, Dania B., Sillence, Martin N., McGree, James M.

“…Background Endocrinopathic laminitis is common in horses and ponies, but the recurrence rate of the disease is poorly defined. Objectives To determine the…”
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The effect of diet change and insulin dysregulation on the faecal microbiome of ponies by Fitzgerald, Danielle M, Spence, Robert J, Stewart, Zachary K, Prentis, Peter J, Sillence, Martin N, de Laat, Melody A

“…The equine microbiome can change in response to dietary alteration and may play a role in insulin dysregulation. The aim of this study was to determine the…”
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Association between insulin dysregulation and adrenocorticotropic hormone in aged horses and ponies with no clinical signs of pituitary pars intermedia dysfunction by Li, Fang I, Spence, Robert J, de Laat, Melody A, Harris, Patricia A, Sonntag, Johanna, Menzies-Gow, Nicola J, Durham, Andy E, Bailey, Simon R, Sillence, Martin N

“…High concentrations of adrenocorticotropic hormone (ACTH) are used as an indicator of pituitary pars intermedia dysfunction (PPID), but other factors that may…”
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Expression of the GCG gene and secretion of active glucagon‐like peptide‐1 varies along the length of intestinal tract in horses by Fitzgerald, Danielle M., Cash, Christina M., Dudley, Kevin J., Sibthorpe, Poppy E. M., Sillence, Martin N., Laat, Melody A.

“…Background Active glucagon‐like peptide‐1 (aGLP‐1) has been implicated in the pathogenesis of equine insulin dysregulation (ID), but its role is unclear…”
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Physiological and metabolic effects of short-term dopamine reduction in healthy horses using a tyrosine hydroxylase inhibitor (alpha-methyl-para-tyrosine) by Galinelli, Nicolas C., Bamford, Nicholas J., Erdody, Madison L., Warnken, Tobias, de Laat, Melody A., Sillence, Martin N., Harris, Patricia A., Bailey, Simon R.

“…•Plasma dopamine concentration was reduced after AMPT administration.•AMPT induced a spike in plasma prolactin, indicating central reduction of dopamine.•No…”
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