Search Results - "de Laat, M.A."

The developmental and acute phases of insulin-induced laminitis involve minimal metalloproteinase activity by de Laat, M.A., Kyaw-Tanner, M.T., Nourian, A.R., McGowan, C.M., Sillence, M.N., Pollitt, C.C.

“…Metalloproteinases have been implicated in the pathogenesis of equine laminitis and other inflammatory conditions, through their role in the degradation and…”
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Diagnosis of equine endocrinopathies: The value of measuring blood glucose during an oral glucose test by de Laat, M.A., Sillence, M.N.

“…Blood glucose concentration is often measured during an oral glucose test (OGT), but is not thought to aid in diagnosing insulin dysregulation (ID) or…”
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The oral glucose test predicts laminitis risk in ponies fed a diet high in nonstructural carbohydrates by Meier, A.D., de Laat, M.A., Reiche, D.B., Pollitt, C.C., Walsh, D.M., McGree, J.M., Sillence, M.N.

“…The aim of this study was to investigate the relationship between laminitis development in ponies and insulin/glucose concentrations in response to the oral…”
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Ultrastructural examination of basement membrane pathology in horses with insulin-induced laminitis by de Laat, M.A., Pollitt, C.C.

“…The third phalanx of the equine digit is suspended within the hoof capsule by a specialized interdigitating dermoepidermal layer called the lamellae, which…”
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Prolonged hyperinsulinemia increases the production of inflammatory cytokines in equine digital lamellae but not in striated muscle by Jayathilake, W.M.N.K., de Laat, M.A., Furr, M., Risco, C., Lacombe, V.A.

“…Hyperinsulinemia is the key feature of equine metabolic syndrome (EMS) which leads to debilitating sequelae. Hyperinsulinemia-associated laminitis (HAL) is one…”
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Studies in vitro of equine intestinal glucagon-like peptide-2 secretion by Sibthorpe, P.E.M., Fitzgerald, D.M., Sillence, M.N., de Laat, M.A.

“…•GLP-2 secretion was higher from the jejunum and ileum, compared to the duodenum.•GLP-2 secretion was responsive to glucose in the jejunum.•GLP-2 secretion was…”
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Equine laminitis: Induced by 48 h hyperinsulinaemia in Standardbred horses by De Laat, M.A, McGowan, C.M, Sillence, M.N, Pollitt, C.C

“…Summary Reasons for performing study: Hyperinsulinaemia is known to induce laminitis experimentally in healthy ponies with no history of the condition. Horses…”
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Sustained, Low‐Intensity Exercise Achieved by a Dynamic Feeding System Decreases Body Fat in Ponies by Laat, M.A., Hampson, B.A., Sillence, M.N., Pollitt, C.C.

“…Background Obesity in horses is increasing in prevalence and can be associated with insulin insensitivity and laminitis. Current treatment strategies for…”
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Preliminary analysis of the FAM174A gene suggests it lacks a strong association with equine metabolic syndrome in ponies by Cash, C.M., Fitzgerald, D.M., Spence, R.J., de Laat, M.A.

“…Equine metabolic syndrome (EMS) describes a group of risk factors, including obesity and insulin dysregulation (hyperinsulinemia and/or insulin resistance),…”
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Glucagon-like peptide-1, insulin-like growth factor-1, and adiponectin in insulin-dysregulated ponies: effects of feeding a high nonstructural carbohydrate diet and association with prospective laminitis by Meier, A.D., de Laat, M.A., Reiche, D.B., Sillence, M.N.

“…Endocrinopathic laminitis, related to equine metabolic syndrome and insulin dysregulation, causes marked pain and suffering in horses and represents a…”
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Effects of insulin on IGF-1 receptors in equine lamellar tissue in vitro by Rahnama, S., Spence, R., Vathsangam, N., Baskerville, C.L., Bailey, S.R., de Laat, M.A., Anderson, S.T., Pollitt, C.C., Sillence, M.N.

“…Although it is understood that equine endocrinopathic laminitis can be triggered by high concentrations of insulin, it is unclear whether this represents a…”
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Characterization of insulin and IGF-1 receptor binding in equine liver and lamellar tissue: implications for endocrinopathic laminitis by Nanayakkara, S.N., Rahnama, S., Harris, P.A., Anderson, S.T., de Laat, M.A., Bailey, S., Sillence, M.N.

“…Although it is well established that equine laminitis can be triggered by extreme hyperinsulinemia, the mechanism of insulin action is not known. High…”
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Identification of monoclonal antibodies suitable for blocking IGF-1 receptors in the horse by Rahnama, S., Vathsangam, N., Spence, R., Anderson, S.T., de Laat, M.A., Bailey, S., Sillence, M.N.

“…Prolonged hyperinsulinemia is thought to be the cause of equine endocrinopathic laminitis, a common and crippling disease of the foot, for which there are no…”
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Equine Laminitis: Comparative Histopathology 48 hours after Experimental Induction with Insulin or Alimentary Oligofructose in Standardbred Horses by de Laat, M.A., van Eps, A.W., McGowan, C.M., Sillence, M.N., Pollitt, C.C.

“…Laminitis has many triggers and comparing the histopathology of lesions induced by different causes may help to establish whether a common mechanism or…”
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Prolonged hyperinsulinemia affects metabolic signal transduction markers in a tissue specific manner by Campolo, A., de Laat, M.A., Keith, L., Gruntmeir, K.J., Lacombe, V.A.

“…Insulin dysregulation is common in horses although the mechanisms of metabolic dysfunction are poorly understood. We hypothesized that insulin signaling in…”
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AICAR administration affects glucose metabolism by upregulating the novel glucose transporter, GLUT8, in equine skeletal muscle by de Laat, M.A., Robinson, M.A., Gruntmeir, K.J., Liu, Y., Soma, L.R., Lacombe, V.A.

“…•The role of AMPK in regulating glucose metabolism in horses is unknown.•AICAR administration induces transient hypoglycaemia and hyperinsulinaemia in…”
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Advanced glycation endproducts in horses with insulin-induced laminitis by de Laat, M.A., Kyaw-Tanner, M.T., Sillence, M.N., McGowan, C.M., Pollitt, C.C.

“…Advanced glycation endproducts (AGEs) have been implicated in the pathogenesis of cancer, inflammatory conditions and diabetic complications. An interaction of…”
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Toll-like receptor and pro-inflammatory cytokine expression during prolonged hyperinsulinaemia in horses: Implications for laminitis by de Laat, M.A., Clement, C.K., McGowan, C.M., Sillence, M.N., Pollitt, C.C., Lacombe, V.A.

“…Equine laminitis, a disease of the lamellar structure of the horse's hoof, can be incited by numerous factors that include inflammatory and metabolic…”
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Repeatability of an In-Feed Sugar Test in Ponies by de Laat, M.A., Pollitt, C.C., Sillence, M.N.

“…Reasons for performing study Insulin resistance (IR) can be difficult to diagnose from basal insulin and glucose concentrations, so a field‐based oral sugar…”
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Novel keratins identified by quantitative proteomic analysis as the major cytoskeletal proteins of equine (Equus caballus) hoof lamellar tissue by Carter, R.A, Shekk, V, de Laat, M.A, Pollitt, C.C, Galantino-Homer, H.L

“…The dermo-epidermal interface that connects the equine distal phalanx to the cornified hoof wall withstands great biomechanical demands, but is also a region…”
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