Search Results - "de Koning, Eelco J P"

Pancreatic β-Cell Identity Change through the Lens of Single-Cell Omics Research by Leenders, Floris, de Koning, Eelco J P, Carlotti, Françoise

“…The main hallmark in the development of both type 1 and type 2 diabetes is a decline in functional β-cell mass. This decline is predominantly attributed to…”
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Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress by Groen, Nathalie, Leenders, Floris, Mahfouz, Ahmed, Munoz-Garcia, Amadeo, Muraro, Mauro J, de Graaf, Natascha, Rabelink, Ton J, Hoeben, Rob, van Oudenaarden, Alexander, Zaldumbide, Arnaud, Reinders, Marcel J T, Koning, Eelco J P de, Carlotti, Françoise

“…The maintenance of pancreatic islet architecture is crucial for proper β-cell function. We previously reported that disruption of human islet integrity could…”
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Organoids from the Human Fetal and Adult Pancreas by Balak, Jeetindra R. A., Juksar, Juri, Carlotti, Françoise, Lo Nigro, Antonio, de Koning, Eelco J. P.

“…Purpose of Review Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and…”
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DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells by Roost, Matthias S., Slieker, Roderick C., Bialecka, Monika, van Iperen, Liesbeth, Gomes Fernandes, Maria M., He, Nannan, Suchiman, H. Eka D., Szuhai, Karoly, Carlotti, Françoise, de Koning, Eelco J. P., Mummery, Christine L., Heijmans, Bastiaan T., Chuva de Sousa Lopes, Susana M.

“…Determining cell identity and maturation status of differentiated pluripotent stem cells (PSCs) requires knowledge of the transcriptional and epigenetic…”
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Pancreatic islet macroencapsulation using microwell porous membranes by Skrzypek, Katarzyna, Groot Nibbelink, Milou, van Lente, Jéré, Buitinga, Mijke, Engelse, Marten A., de Koning, Eelco J. P., Karperien, Marcel, van Apeldoorn, Aart, Stamatialis, Dimitrios

“…Allogeneic islet transplantation into the liver in combination with immune suppressive drug therapy is widely regarded as a potential cure for type 1 diabetes…”
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DNA Methylation Landscapes of Human Fetal Development by Slieker, Roderick C, Roost, Matthias S, van Iperen, Liesbeth, Suchiman, H Eka D, Tobi, Elmar W, Carlotti, Françoise, de Koning, Eelco J P, Slagboom, P Eline, Heijmans, Bastiaan T, Chuva de Sousa Lopes, Susana M

“…Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, current knowledge of DNA methylation dynamics in human…”
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Association between person and disease related factors and the planned diabetes care in people who receive person-centered type 2 diabetes care: An implementation study by van Vugt, Heidi A, de Koning, Eelco J P, Rutten, Guy E H M

“…To assess the planned diabetes care for the coming year and its associated factors in patients with Type 2 diabetes who have a person-centered annual…”
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Advances in β-cell replacement therapy for the treatment of type 1 diabetes by Vantyghem, Marie-Christine, de Koning, Eelco J P, Pattou, François, Rickels, Michael R

“…The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to reduce disease complications. For some patients, technological…”
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COVID-19 and Diabetes: Understanding the Interrelationship and Risks for a Severe Course by Landstra, Cyril P, de Koning, Eelco J P

“…The relationship between COVID-19 and diabetes mellitus is complicated and bidirectional. On the one hand, diabetes mellitus is considered one of the most…”
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Generation of L Cells in Mouse and Human Small Intestine Organoids by PETERSEN, Natalia, REIMANN, Frank, BARTFELD, Sina, FARIN, Henner F, RINGNALDA, Femke C, VRIES, Robert G. J, VAN DEN BRINK, Stieneke, CLEVERS, Hans, GRIBBLE, Fiona M, DE KONING, Eelco J. P

“…Upon a nutrient challenge, L cells produce glucagon-like peptide 1 (GLP-1), a powerful stimulant of insulin release. Strategies to augment endogenous GLP-1…”
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The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion by Spinnler, Robert, Gorski, Theresa, Stolz, Katharina, Schuster, Susanne, Garten, Antje, Beck-Sickinger, Annette G, Engelse, Marten A, de Koning, Eelco J P, Körner, Antje, Kiess, Wieland, Maedler, Kathrin

“…Obesity is associated with a dysregulation of beta-cell and adipocyte function. The molecular interactions between adipose tissue and beta-cells are not yet…”
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Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes by Kracht, Maria J L, van Lummel, Menno, Nikolic, Tatjana, Joosten, Antoinette M, Laban, Sandra, van der Slik, Arno R, van Veelen, Peter A, Carlotti, Françoise, de Koning, Eelco J P, Hoeben, Rob C, Zaldumbide, Arnaud, Roep, Bart O

“…Use of an alternative open reading frame, potentially as a result of cellular stress, drives production of an unconventional insulin epitope that is recognized…”
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Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors by Kirkpatrick, Clare L, Marchetti, Piero, Purrello, Francesco, Piro, Salvatore, Bugliani, Marco, Bosco, Domenico, de Koning, Eelco J P, Engelse, Marten A, Kerr-Conte, Julie, Pattou, François, Wollheim, Claes B

“…Genome-wide association studies have identified susceptibility genes for development of type 2 diabetes. We aimed to examine whether a subset of these…”
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Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity by Leenders, Floris, Groen, Nathalie, de Graaf, Natascha, Engelse, Marten A, Rabelink, Ton J, de Koning, Eelco J P, Carlotti, Françoise

“…Pancreatic β-cell failure is a critical event in the onset of both main types of diabetes mellitus but underlying mechanisms are not fully understood. β-cells…”
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Incidence and prevalence of thyroid dysfunction in type 1 diabetes by Nederstigt, Christa, Corssmit, Eleonora P.M, de Koning, Eelco J.P, Dekkers, Olaf M

“…Abstract Aims To estimate prevalence and incidence of auto-immune thyroid disease and thyroid auto-antibodies in an unselected cohort of patients with DM1,…”
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Clinical use of donation after circulatory death pancreas for islet transplantation by Doppenberg, Jason B., Nijhoff, Michiel F., Engelse, Marten A., Koning, Eelco J. P.

“…Due to a shortage of donation after brain death (DBD) organs, donation after circulatory death (DCD) is increasingly performed. In the field of islet…”
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Human stomach tissue as alternative source of insulin-producing cells by de Koning, Eelco J. P., Carlotti, Françoise

“…Pancreatic islet cell replacement therapy is a promising strategy for patients with type 1 diabetes mellitus, but the scarcity of organ donors and need for…”
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Critical comments regarding the assessment of quality of life and the clinical impact of the POWER2DM intervention. Reply to Pouwer F, Deschênes SS [letter] by Ruissen, Merel M., Steyerberg, Ewout W., Huisman, Sasja D., de Graaf, Albert A., de Koning, Eelco J. P., Delgado-Lista, Javier, Sont, Jacob K.

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Increased stress, weight gain and less exercise in relation to glycemic control in people with type 1 and type 2 diabetes during the COVID-19 pandemic by Ruissen, Merel M, Regeer, Hannah, Landstra, Cyril P, Schroijen, Marielle, Jazet, Ingrid, Nijhoff, Michiel F, Pijl, Hanno, Ballieux, Bart E P B, Dekkers, Olaf, Huisman, Sasja D, de Koning, Eelco J P

“…IntroductionLockdown measures have a profound effect on many aspects of daily life relevant for diabetes self-management. We assessed whether lockdown…”
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Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium by van den Berg, Bernard M, Wang, Gangqi, Boels, Margien G S, Avramut, M Cristina, Jansen, Erik, Sol, Wendy M P J, Lebrin, Franck, van Zonneveld, Anton Jan, de Koning, Eelco J P, Vink, Hans, Gröne, Hermann-Josef, Carmeliet, Peter, van der Vlag, Johan, Rabelink, Ton J

“…A glycocalyx envelope consisting of proteoglycans and adhering proteins covers endothelial cells, both the luminal and abluminal surface. We previously…”
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