Search Results - "de Kok, Theo M"

Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks by Krauskopf, Julian, van Veldhoven, Karin, Chadeau-Hyam, Marc, Vermeulen, Roel, Carrasco-Turigas, Glòria, Nieuwenhuijsen, Mark, Vineis, Paolo, de Kok, Theo M., Kleinjans, Jos C.

“…Traffic-related air pollution (TRAP) is a complex mixture of compounds that contributes to the pathogenesis of many diseases including several types of cancer,…”
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Allele-specific expression analysis for complex genetic phenotypes applied to a unique dilated cardiomyopathy cohort by van Beek, Daan, Verdonschot, Job, Derks, Kasper, Brunner, Han, de Kok, Theo M., Arts, Ilja C. W., Heymans, Stephane, Kutmon, Martina, Adriaens, Michiel

“…Allele-specific expression (ASE) analysis detects the relative abundance of alleles at heterozygous loci as a proxy for cis -regulatory variation, which…”
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Author Correction: Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx by He, Yueqin, DeBenedictis, Julia Nicole, Caiment, Florian, van Breda, Simone G. J., de Kok, Theo M. C. M.

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Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx by He, Yueqin, DeBenedictis, Julia Nicole, Caiment, Florian, van Breda, Simone G. J., de Kok, Theo M. C. M.

“…Diet is an important determinant of overall health, and has been linked to the risk of various cancers. To understand the mechanisms involved, transcriptomic…”
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Comparison of statistical methods and the use of quality control samples for batch effect correction in human transcriptome data by Espín-Pérez, Almudena, Portier, Chris, Chadeau-Hyam, Marc, van Veldhoven, Karin, Kleinjans, Jos C S, de Kok, Theo M C M

“…Batch effects are technical sources of variation introduced by the necessity of conducting gene expression analyses on different dates due to the large number…”
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Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data by O'Donovan, Shauna D, Cavill, Rachel, Wimmenauer, Florian, Lukas, Alexander, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G. J, van Riel, Natal A. W, Driessens, Kurt, Peeters, Ralf L. M, de Kok, Theo M. C. M

“…The liver is the primary site for the metabolism and detoxification of many compounds, including pharmaceuticals. Consequently, it is also the primary location…”
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Drinking Water Nitrate and Human Health: An Updated Review by Ward, Mary H, Jones, Rena R, Brender, Jean D, de Kok, Theo M, Weyer, Peter J, Nolan, Bernard T, Villanueva, Cristina M, van Breda, Simone G

“…Nitrate levels in our water resources have increased in many areas of the world largely due to applications of inorganic fertilizer and animal manure in…”
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Molecular insights into PCB neurotoxicity: Comparing transcriptomic responses across dopaminergic neurons, population blood cells, and Parkinson's disease pathology by Krauskopf, Julian, Eggermont, Kristel, Caiment, Florian, Verfaillie, Catherine, de Kok, Theo M.

“…[Display omitted] •We utilized iPSC-derived dopaminergic neurons to model PCB-induced neurotoxicity in Parkinson's disease.•We assessed transcriptomic changes…”
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Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes by O'Donovan, Shauna D, Driessens, Kurt, Lopatta, Daniel, Wimmenauer, Florian, Lukas, Alexander, Neeven, Jelmer, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G J, van Riel, Natal A W, Cavill, Rachel, Peeters, Ralf L M, de Kok, Theo M C M

“…In clinical trials, animal and cell line models are often used to evaluate the potential toxic effects of a novel compound or candidate drug before progressing…”
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Adipose tissue in health and disease through the lens of its building blocks by Lenz, Michael, Arts, Ilja C. W., Peeters, Ralf L. M., de Kok, Theo M., Ertaylan, Gökhan

“…Understanding adipose tissue cellular heterogeneity and homeostasis is essential to comprehend the cell type dynamics in metabolic diseases. Cellular…”
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A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data by O'Donovan, Shauna D, Lenz, Michael, Vink, Roel G, Roumans, Nadia J T, de Kok, Theo M C M, Mariman, Edwin C M, Peeters, Ralf L M, van Riel, Natal A W, van Baak, Marleen A, Arts, Ilja C W

“…Given the association of disturbances in non-esterified fatty acid (NEFA) metabolism with the development of Type 2 Diabetes and Non-Alcoholic Fatty Liver…”
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Correction to “Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways” by Cheng, Sibo Lucas, Hedges, Michael, Keski-Rahkonen, Pekka, Chatziioannou, Anastasia Chrysovalantou, Scalbert, Augustin, Chung, Kian Fan, Sinharay, Rudy, Green, David C., de Kok, Theo M. C. M., Vlaanderen, Jelle, Kyrtopoulos, Soterios A., Kelly, Frank, Portengen, Lützen, Vineis, Paolo, Vermeulen, Roel C. H., Chadeau-Hyam, Marc, Dagnino, Sonia

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Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator by O’Donovan, Shauna D., Lenz, Michael, Goossens, Gijs H., van der Kallen, Carla J. H., Eussen, Simone J. M. P., Stehouwer, Coen D. A., van Greevenbroek, Marleen M., Schram, Miranda T., Sep, Simone J., Peeters, Ralf L. M., Blaak, Ellen E., van Riel, Natal A. W., de Kok, Theo M. C. M., Arts, Ilja C. W.

“…The Muscle Insulin Sensitivity Index (MISI) has been developed to estimate muscle-specific insulin sensitivity based on oral glucose tolerance test (OGTT)…”
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Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System by Bischoff, Nicolaj S, de Kok, Theo M, Sijm, Dick T H M, van Breda, Simone G, Briedé, Jacco J, Castenmiller, Jacqueline J M, Opperhuizen, Antoon, Chirino, Yolanda I, Dirven, Hubert, Gott, David, Houdeau, Eric, Oomen, Agnes G, Poulsen, Morten, Rogler, Gerhard, van Loveren, Henk

“…Titanium dioxide (TiO ) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as…”
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A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism by Alfano, Rossella, Chadeau-Hyam, Marc, Ghantous, Akram, Keski-Rahkonen, Pekka, Chatzi, Leda, Perez, Almudena Espin, Herceg, Zdenko, Kogevinas, Manolis, de Kok, Theo M., Nawrot, Tim S., Novoloaca, Alexei, Patel, Chirag J., Pizzi, Costanza, Robinot, Nivonirina, Rusconi, Franca, Scalbert, Augustin, Sunyer, Jordi, Vermeulen, Roel, Vrijheid, Martine, Vineis, Paolo, Robinson, Oliver, Plusquin, Michelle

“…Birthweight reflects in utero exposures and later health evolution. Despite existing studies employing high-dimensional molecular measurements, the…”
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New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids by Rodrigues, Daniela, de Souza, Terezinha, Coyle, Luke, Di Piazza, Matteo, Herpers, Bram, Ferreira, Sofia, Zhang, Mian, Vappiani, Johanna, Sévin, Daniel C., Gabor, Attila, Lynch, Anthony, Chung, Seung-Wook, Saez-Rodriguez, Julio, Jennen, Danyel G. J., Kleinjans, Jos C. S., de Kok, Theo M.

“…5-Fluorouracil (5-FU) is a widely used chemotherapeutical that induces acute toxicity in the small and large intestine of patients. Symptoms can be severe and…”
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The role of red and processed meat in colorectal cancer development: a perspective by Oostindjer, Marije, Alexander, Jan, Amdam, Gro V., Andersen, Grethe, Bryan, Nathan S., Chen, Duan, Corpet, Denis E., De Smet, Stefaan, Dragsted, Lars Ove, Haug, Anna, Karlsson, Anders H., Kleter, Gijs, de Kok, Theo M., Kulseng, Bård, Milkowski, Andrew L., Martin, Roy J., Pajari, Anne-Maria, Paulsen, Jan Erik, Pickova, Jana, Rudi, Knut, Sødring, Marianne, Weed, Douglas L., Egelandsdal, Bjørg

“…This paper is based on a workshop held in Oslo, Norway in November 2013, in which experts discussed how to reach consensus on the healthiness of red and…”
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Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids by Rodrigues, Daniela, Coyle, Luke, Füzi, Barbara, Ferreira, Sofia, Jo, Heeseung, Herpers, Bram, Chung, Seung-Wook, Fisher, Ciarán, Kleinjans, Jos C S, Jennen, Danyel, de Kok, Theo M

“…Doxorubicin is widely used in the treatment of different cancers, and its side effects can be severe in many tissues, including the intestines. Symptoms such…”
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MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery by Krauskopf, Julian, de Kok, Theo M., Hebels, Dennie G., Bergdahl, Ingvar A., Johansson, Anders, Spaeth, Florentin, Kiviranta, Hannu, Rantakokko, Panu, Kyrtopoulos, Soterios A., Kleinjans, Jos C.

“…Persistent organic pollutants (POPs) are synthetic chemical substances that accumulate in our environment. POPs such as polychlorinated biphenyls (PCBs),…”
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Improved Preventive Effects of Combined Bioactive Compounds Present in Different Blueberry Varieties as Compared to Single Phytochemicals by van Breda, Simone G J, Briedé, Jacob J, de Kok, Theo M C M

“…Blueberries contain many different phytochemicals which might be responsible for their disease preventive properties. In a previously conducted human dietary…”
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