Search Results - "de Kluyver, Rachel"

Breast cancer bone metastases: Combination therapy targeting cancer cells and the tumor microenvironment by de Kluyver, Rachel L., Sayers, Thomas J.

“…Commentary to: Combined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of…”
Get full text

Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity by Shanker, Anil, Pellom, Jr, Samuel T, Dudimah, Duafalia F, Thounaojam, Menaka C, de Kluyver, Rachel L, Brooks, Alan D, Yagita, Hideo, McVicar, Daniel W, Murphy, William J, Longo, Dan L, Sayers, Thomas J

“…Cancer immunotherapy shows great promise but many patients fail to show objective responses, including in cancers that can respond well, such as melanoma and…”
Get full text

A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells by Mathews, Lesley A, Keller, Jonathan M, Goodwin, Bonnie L, Guha, Rajarshi, Shinn, Paul, Mull, Rebecca, Thomas, Craig J, de Kluyver, Rachel L, Sayers, Thomas J, Ferrer, Marc

“…Tumor cell subpopulations called cancer stem cells (CSCs) or tumor-initiating cells (TICs) have self-renewal potential and are thought to drive metastasis and…”
Get more information

Antigen-Specific CD8 T Cells Can Eliminate Antigen-Bearing Keratinocytes with Clonogenic Potential via an IFN-γ-Dependent Mechanism by De Kluyver, Rachel L., Moritz, Linnea, Harris, Craig A., Azukizawa, Hiroaki, Frazer, Ian H.

“…The immune system surveys the skin for keratinocytes (KCs) infected by viruses or with acquired genetic damage. The mechanism by which T cells mediate KC…”
Get full text

Coactivation of AKT and β-Catenin in Mice Rapidly Induces Formation of Lipogenic Liver Tumors by STAUFFER, Jimmy K, SCARZELLO, Anthony J, ANDERSEN, Jesper B, DE KLUYVER, Rachel L, BACK, Timothy C, WEISS, Jonathan M, THORGEIRSSON, Snorri S, WILTROUT, Robert H

“…Obesity is a risk factor for development of certain cancers but the basis for this risk is unclear. In this study, we developed a novel mouse model that…”
Get full text

Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation by Gu, Wenyi, Ding, Jianmin, Wang, Xiao, de Kluyver, Rachel L., Saunders, Nicholas A., Frazer, Ian H., Zhao, Kong-Nan

“…Recently we reported that gene codon composition determines differentiation-dependent expression of the PV L1 genes in mouse primary keratinocytes (KCs) in…”
Get full text

Impaired Antigen Presentation and Effectiveness of Combined Active/Passive Immunotherapy for Epithelial Tumors by Matsumoto, Koji, Leggatt, Graham R., Zhong, Jie, Liu, Xiaosong, de Kluyver, Rachel L., Peters, Tania, Fernando, Germain J. P., Liem, Amy, Lambert, Paul F., Frazer, Ian H.

“…Background: Although immunization with tumor antigens can eliminate many transplantable tumors in animal models, immune effector mechanisms associated with…”
Get full text

Tolerance or Immunity to a Tumor Antigen Expressed in Somatic Cells Can Be Determined by Systemic Proinflammatory Signals at the Time of First Antigen Exposure by Frazer, Ian H, Kluyver, Rachel De, Leggatt, Graham R, Yang Guo, Hua, Dunn, Linda, White, Olivia, Harris, Craig, Liem, Amy, Lambert, Paul

“…Mice transgenic for the E7 tumor Ag of human papillomavirus type 16, driven from a keratin 14 promoter, express E7 in keratinocytes but not dendritic cells…”
Get full text

Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide by Leggatt, Graham R, Dunn, Linda A, De kluyver, Rachel L, Stewart, Trina, Frazer, Ian H

“…Keratinocytes expressing the human papillomavirus (HPV) type 16 E7 protein, as a transgene driven by the K14 promoter, form a murine model of HPV‐mediated…”
Get full text

Abstract 3876: Can Nanog activity identify aggressive breast cancer stem cell populations by Sayers, Thomas J., Kluyver, Rachel de, Kaddoura, Marcella, Stauffer, Jim, Tewary, Poonam, Brooks, Alan D.

“…Many tumors have been demonstrated to contain cancer stem cells (CSC). We hypothesized that expression of transcription factors that are required for induction…”
Get full text

Presentation of the HPV16E7 Protein by Skin Grafts Is Insufficient to Allow Graft Rejection in an E7-Primed Animal by Dunn, Linda A., Evander, Magnus, Tindle, Robert W., Bulloch, Anne Louise, de Kluyver, Rachel L., Fernando, Germain J.P., Lambert, Paul F., Frazer, Ian H.

“…The E7 transforming protein of Human Papillomavirus type 16 (HPV16) is expressed in the skin of a line of FVB mice transgenic for the E6 and E7 open reading…”
Get full text

Impact of bortezomib-induced proteasome inhibition in vivo on anti-tumor T cell responses (101.1) by Shanker, Anil, De Kluyver, Rachel, Sayers, Thomas

“…The perturbation of cellular homeostasis offers a new approach for cancer therapy. Our recent reports showed that proteasome inhibitor bortezomib…”
Get full text

Abstract 2656: Using Nanog expression to identify breast cancer stem cell populations by Brooks, Alan D., de Kluyver, Rachel L., Stauffer, Jimmy K., Kaddoura, Marcella, Sayers, Thomas J.

“…Many tumors have been demonstrated to contain a subpopulation of cancer stem cells (CSC) whose epigenetic modifications convey resistance to conventional…”
Get full text

Abstract 3349: Nanog-expressing breast cancer tumor initiating cells (TICs) are highly metastatic and are resistant to the effects of proteasome inhibition by de Kluyver, Rachel L., Brooks, Alan T., Sayers, Thomas J.

“…Functional heterogeneity of transformed cells exists within a single tumor mass and between distinct tumor nodules. Many tumors have also been demonstrated to…”
Get full text

Abstract 1931: Impact of bortezomib-induced proteasome inhibition in vivo on antitumor T cell responses by Shanker, Anil, Kluyver, Rachel De, Sayers, Thomas J.

“…Inhibition of cellular proteasome function crucial for protein turn-over is a recent approach to overcome the resistance of tumors to cell death, a major…”
Get full text

Invasive pneumococcal disease in Australia, 2011 and 2012 by Toms, Cindy, de Kluyver, Rachel

“…In Australia, there were 1,883 cases (8.3 per 100,000 population) of invasive pneumococcal disease (IPD) notified to the National Notifiable Diseases…”
Get full text

Abstract 4251: Murine hepatocellular carcinoma stem cells express pluri-potency-associated transcription factors and are sensitive to immune-mediated apoptosis by de Kluyver, Rachel L., Stauffer, Jim, Brooks, Alan, Shanker, Anil, Sayers, Tom

“…Worldwide the incidence of hepatocellular carcinoma (HCC) resulting from hepatitis C infection and chronic inflammation is increasing. Poor prognosis HCC is…”
Get full text

Murine Hepatocellular Carcinoma Stem Cells Express Pluripotency-associated Transcription Factors and are Sensitive to Immune Mediated Apoptosis. (101.16) by de Kluyver, Rachel, Stauffer, Jim, Brooks, Alan, Shanker, Anil, Sayers, Tom

“…Current evidence supports the view that cancer stem cells (CSCs) constitute the primary pathogenic component of both metastases and minimal residual disease…”
Get full text

Antigen-Specific CD8 T Cells Can Eliminate Antigen-Bearing Keratinocytes with Clonogenic Potential via an IFN-[gamma]-Dependent Mechanism by De Kluyver, Rachel L, Moritz, Linnea, Harris, Craig A, Azukizawa, Hiroaki, Frazer, Ian H

“…The immune system surveys the skin for keratinocytes (KCs) infected by viruses or with acquired genetic damage. The mechanism by which T cells mediate KC…”
Get full text

Abstract 4375: A molecular carcinogenic approach to modeling hepatocellular carcinoma by Stauffer, Jimmy, Back, Tim, Scarzello, Tony, de Kluyver, Rachel, Subleski, Jeff, Chan, Tim, Jiang, Qun, Weiss, Jon, Wiltrout, Robert

“…The development of accurate disease models is critically important in the ongoing search for better therapies and ultimately cures. Neoplasia manifests through…”
Get full text