Search Results - "de Kloet, E.R."

The three-hit concept of vulnerability and resilience: Toward understanding adaptation to early-life adversity outcome by Daskalakis, Nikolaos P, Bagot, Rosemary C, Parker, Karen J, Vinkers, Christiaan H, de Kloet, E.R

“…Summary Stressful experiences during early-life can modulate the genetic programming of specific brain circuits underlying emotional and cognitive aspects of…”
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Functional profile of the binary brain corticosteroid receptor system: Mediating, multitasking, coordinating, integrating by de Kloet, E.R.

“…This contribution is focused on the action of the naturally occurring corticosteroids, cortisol and corticosterone, which are secreted from the adrenals in…”
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Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation by de Kloet, E.R., Meijer, O.C., de Nicola, A.F., de Rijk, R.H., Joëls, M.

“…•Resilience depends on balanced MR- and GR-mediated actions.•Brain MR promotes appraisal processes, choice of coping style, learning and memory…”
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Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour by Harris, A.P, Holmes, M.C, de Kloet, E.R, Chapman, K.E, Seckl, J.R

“…Summary An imbalance between central glucocorticoid (GR) and mineralocorticoid (MR) receptors is proposed to underlie the HPA axis dysregulation that…”
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Mineralocorticoid receptor haplotype, oral contraceptives and emotional information processing by Hamstra, D.A, de Kloet, E.R, van Hemert, A.M, de Rijk, R.H, Van der Does, A.J.W

“…Highlights • Oral contraceptives (OCs) affect emotional information processing. • MR haplotype moderates the effects of OCs on emotion recognition and recall…”
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Glucocorticoid signaling and stress-related limbic susceptibility pathway: About receptors, transcription machinery and microRNA by de Kloet, E.R, Fitzsimons, C.P, Datson, N.A, Meijer, O.C, Vreugdenhil, E

“…Abstract Background. Stress is essential for health, but if coping with stress fails, the action of the stress hormones cortisol and corticosterone (CORT)…”
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Glucocorticoid pulsatility and rapid corticosteroid actions in the central stress response by Sarabdjitsingh, R.A, Joëls, M, de Kloet, E.R

“…Abstract Glucocorticoid hormones are secreted from the adrenal gland in hourly pulses, on top of which a surge can take place after stress. The current review…”
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Corticosterone facilitates extinction of fear memory in BALB/c mice but strengthens cue related fear in C57BL/6 mice by Brinks, V., de Kloet, E.R., Oitzl, M.S.

“…Corticosterone, the naturally occurring glucocorticoid of rodents is secreted in response to stressors and is known for its facilitating and detrimental…”
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Mineralocorticoid receptors in control of emotional arousal and fear memory by Brinks, V., Berger, S., Gass, P., de Kloet, E.R., Oitzl, M.S.

“…The stress hormone corticosterone acts via two receptor types in the brain: the mineralocorticoid (MR) and the glucocorticoid receptor (GR). Both receptors are…”
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The postnatal development of the hypothalamic–pituitary–adrenal axis in the mouse by Schmidt, M., Enthoven, L., Mark, M., Levine, S., Kloet, E.R., Oitzl, M.S.

“…The main characteristic of the postnatal development of the stress system in the rat is the so‐called stress hypo‐responsive period (SHRP). Lasting from…”
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A molecular blueprint of gene expression in hippocampal subregions CA1, CA3, and DG is conserved in the brain of the common marmoset by Datson, N.A., Morsink, M.C., Steenbergen, P.J., Aubert, Y., Schlumbohm, C., Fuchs, E., de Kloet, E.R.

“…Recent studies in rodents have shown that there are significant differences in gene expression profiles between the hippocampal subregions CA1, CA3, and DG…”
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S.04.06 Stress-induced enhancement of mouse amygdalar synaptic plasticity depends on both glucocorticoid and β-adrenergic activity by Sarabdjitsingh, R.A, Kofink, D, Karst, H, de Kloet, E.R, Joëls, M

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PL.02 Susceptibility or resilience to psychopathology? A question of stress, genes and balance by De Kloet, E.R

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P.1.017 Stress-induced enhancement of synaptic plasticity in the amygdala of mice depends on both glucocorticoid and -adrenergic activity by Sarabdjitsingh, R.A, Kofink, D, Karst, H, de Kloet, E.R, Joëls, M

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P.4.009 Schizophrenia endophenotypes and stress hyper-reactivity co-precipitate following adverse life events in genetically susceptible rats by Daskalakis, N.P, Martens, G.J, Cools, A.R, de Kloet, E.R

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Ontogeny of the HPA axis of the CD1 mouse following 24 h maternal deprivation at pnd 3 by Enthoven, L., Schmidt, M.V., Cheung, Y.H., Mark, M.H., Kloet, E.R., Oitzl, M.S.

“…One of the striking characteristics of the developing neuroendocrine system of rats and mice is the stress hypo‐responsive period (SHRP), i.e. low basal…”
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Strain differences in the effects of adrenalectomy on the midbrain dopamine system: Implication for behavioral sensitization to cocaine by de Jong, I.E.M, Steenbergen, P.J, de Kloet, E.R

“…Abstract Adrenalectomy (ADX) abolishes behavioral sensitization to cocaine in DBA/2, but not C57BL/6 inbred mice. The present study tests the hypothesis that…”
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Is stress a trigger factor for migraine? by Schoonman, G.G, Evers, D.J, Ballieux, B.E, de Geus, E.J, de Kloet, E.R, Terwindt, G.M, van Dijk, J.G, Ferrari, M.D

“…Summary Background Although mental stress is commonly considered to be an important trigger factor for migraine, experimental evidence for this belief is yet…”
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Rapid glucocorticoid effects on the expression of hippocampal neurotransmission-related genes by Morsink, M.C, Van Gemert, N.G, Steenbergen, P.J, Joëls, M, De Kloet, E.R, Datson, N.A

“…Abstract We previously assessed corticosterone mediated gene expression in acute explant hippocampal slices and found over 200 responsive genes 1, 3 and 5 h…”
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Differential development of stress system (re)activity at weaning dependent on time of disruption of maternal care by Enthoven, L, de Kloet, E.R, Oitzl, M.S

“…Abstract Maternal deprivation, a separation of mother and pups for 24 h in the first weeks of life has long-lasting consequences for the glucocorticoid stress…”
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