Search Results - "de Kleijn, Dominique"

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs by Chen, Tian Sheng, Arslan, Fatih, Yin, Yijun, Tan, Soon Sim, Lai, Ruenn Chai, Choo, Andre Boon Hwa, Padmanabhan, Jayanthi, Lee, Chuen Neng, de Kleijn, Dominique P V, Lim, Sai Kiang

“…Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion…”
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Colchicine Attenuates Inflammation Beyond the Inflammasome in Chronic Coronary Artery Disease: A LoDoCo2 Proteomic Substudy by Opstal, Tjerk S.J., Hoogeveen, Renate M., Fiolet, Aernoud T.L., Silvis, Max J.M., The, Salem H.K., Bax, Willem A., de Kleijn, Dominique P.V., Mosterd, Arend, Stroes, Erik S.G., Cornel, Jan H.

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Exenatide Reduces Infarct Size and Improves Cardiac Function in a Porcine Model of Ischemia and Reperfusion Injury by Timmers, Leo, MD, PhD, Henriques, José P.S., MD, de Kleijn, Dominique P.V., PhD, DeVries, J. Hans, MD, PhD, Kemperman, Hans, PhD, Steendijk, Paul, PhD, Verlaan, Cees W.J., BSc, Kerver, Marjolein, MSc, Piek, Jan J., MD, PhD, FACC, Doevendans, Pieter A., MD, PhD, Pasterkamp, Gerard, MD, PhD, Hoefer, Imo E., MD, PhD

“…Objectives This study sought to examine whether exenatide is capable of reducing myocardial infarct size. Background Exenatide is a glucagon-like peptide…”
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Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology by Sluijter, Joost Petrus Gerardus, Davidson, Sean Michael, Boulanger, Chantal M, Buzás, Edit Iren, de Kleijn, Dominique Paschalis Victor, Engel, Felix Benedikt, Giricz, Zoltán, Hausenloy, Derek J, Kishore, Raj, Lecour, Sandrine, Leor, Jonathan, Madonna, Rosalinda, Perrino, Cinzia, Prunier, Fabrice, Sahoo, Susmita, Schiffelers, Ray Michel, Schulz, Rainer, Van Laake, Linda Wilhelmina, Ytrehus, Kirsti, Ferdinandy, Péter

“…Abstract Extracellular vesicles (EVs)-particularly exosomes and microvesicles (MVs)-are attracting considerable interest in the cardiovascular field as the…”
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Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction by Allijn, Iris E., Czarny, Bertrand M.S., Wang, Xiaoyuan, Chong, Suet Yen, Weiler, Marek, da Silva, Acarilia Eduardo, Metselaar, Josbert M., Lam, Carolyn Su Ping, Pastorin, Giorgia, de Kleijn, Dominique P.V., Storm, Gert, Wang, Jiong-Wei, Schiffelers, Raymond M.

“…Inflammation is a known mediator of adverse ventricular remodeling after myocardial infarction (MI) that may lead to reduction of ejection fraction and…”
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Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti-Toll-Like Receptor-2 Antibody by ARSLAN, Fatih, SMEETS, Mirjam B, DE KLEIJN, Dominique P. V, O'NEILL, Luke A. J, KEOGH, Brian, MCGUIRK, Peter, TIMMERS, Leo, TERSTEEG, Claudia, HOEFER, Imo E, DOEVENDANS, Pieter A, PASTERKAMP, Gerard

“…Reperfusion therapy for myocardial infarction is hampered by detrimental inflammatory responses partly via Toll-like receptor (TLR) activation. Targeting TLR…”
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Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation by Schnitzler, Johan G., Hoogeveen, Renate M., Ali, Lubna, Prange, Koen H.M., Waissi, Farahnaz, van Weeghel, Michel, Bachmann, Julian C., Versloot, Miranda, Borrelli, Matthew J., Yeang, Calvin, De Kleijn, Dominique P.V., Houtkooper, Riekelt H., Koschinsky, Marlys L., de Winther, Menno P.J., Groen, Albert K., Witztum, Joseph L., Tsimikas, Sotirios, Stroes, Erik S.G., Kroon, Jeffrey

“…Patients with elevated levels of lipoprotein(a) [Lp(a)] are hallmarked by increased metabolic activity in the arterial wall on positron emission…”
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Innate immunity as a target for acute cardioprotection by Zuurbier, Coert J, Abbate, Antonio, Cabrera-Fuentes, Hector A, Cohen, Michael V, Collino, Massimo, De Kleijn, Dominique P V, Downey, James M, Pagliaro, Pasquale, Preissner, Klaus T, Takahashi, Masafumi, Davidson, Sean M

“…Acute obstruction of a coronary artery causes myocardial ischaemia and if prolonged, may result in an ST-segment elevation myocardial infarction (STEMI)…”
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Damage-Associated Molecular Patterns in Myocardial Infarction and Heart Transplantation: The Road to Translational Success by Silvis, Max J M, Kaffka Genaamd Dengler, Selma E, Odille, Clémence A, Mishra, Mudit, van der Kaaij, Niels P, Doevendans, Pieter A, Sluijter, Joost P G, de Kleijn, Dominique P V, de Jager, Saskia C A, Bosch, Lena, van Hout, Gerardus P J

“…In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to occlusion (ischemia) and subsequent re-establishment of blood…”
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Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction by Timmers, Leo, Sluijter, Joost P.G, van Keulen, J Karlijn, Hoefer, Imo E, Nederhoff, Marcel G.J, Goumans, Marie-Jose, Doevendans, Pieter A, van Echteld, Cees J.A, Joles, Jaap A, Quax, Paul H, Piek, Jan J, Pasterkamp, Gerard, de Kleijn, Dominique P.V

“…Left ventricular (LV) remodeling leads to congestive heart failure and is a main determinant of morbidity and mortality following myocardial infarction…”
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High Neutrophil Numbers in Human Carotid Atherosclerotic Plaques Are Associated With Characteristics of Rupture-Prone Lesions by Ionita, Mihaela G, van den Borne, Pleunie, Catanzariti, Louise M, Moll, Frans L, de Vries, Jean-Paul P.M, Pasterkamp, Gerard, Vink, Aryan, de Kleijn, Dominique P.V

“…OBJECTIVE—To score the number of plaque neutrophils and relate the score to plaque morphology and inflammatory status. METHODS AND RESULTS—Neutrophils are…”
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Symptomatic Carotid Atherosclerotic Disease: Correlations Between Plaque Composition and Ipsilateral Stroke Risk by Howard, Dominic P.J, van Lammeren, Guus W, Rothwell, Peter M, Redgrave, Jessica N, Moll, Frans L, de Vries, Jean-Paul P.M, de Kleijn, Dominique P.V, den Ruijter, Hester M, de Borst, Gert Jan, Pasterkamp, Gerard

“…BACKGROUND AND PURPOSE—For symptomatic patients with carotid artery stenosis, the risk benefit for surgical intervention may vary among patient groups. Various…”
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Extracellular Vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain by Dekker, Mirthe, Waissi, Farahnaz, van Bennekom, Joelle, Silvis, Max J M, Timmerman, Nathalie, Schoneveld, Arjan H, Grobbee, Diederick E, de Winter, Robbert J, Mosterd, Arend, Timmers, Leo, de Kleijn, Dominique P V

“…Despite the use of high-sensitive cardiac troponin there remains a group of high-sensitive cardiac troponin negative patients with unstable angina with a…”
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High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome by Dekker, Mirthe, Waissi, Farahnaz, Silvis, Max J. M., Bennekom, Joelle V., Schoneveld, Arjan H., de Winter, Robbert J., Isgum, Ivana, Lessmann, Nikolas, Velthuis, Birgitta K., Pasterkamp, Gerard, Mosterd, Arend, Timmers, Leo, de Kleijn, Dominique P. V.

“…Plasma osteoprotegerin (OPG) and vascular smooth muscle cell (VSMC) derived extracellular vesicles (EVs) are important regulators in the process of vascular…”
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Predictors of bleeding complications during catHeter-dirEcted thrombolysis for peripheral arterial occlusions (POCHET) by Mol, Barend M, Verwer, Maarten C, Fijnheer, Rob, Florie, Jasper, Groot, Oscar A, Hietbrink, Falco, Nijkeuter, Mathilde, Vonken, Evert-Jan P A, van Weel, Vincent, de Kleijn, Dominique P V, de Borst, Gert J

“…The risk of major bleeding complications in catheter directed thrombolysis (CDT) for acute limb ischemia (ALI) remains high, with reported major bleeding…”
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Composition of Carotid Atherosclerotic Plaque Is Associated With Cardiovascular Outcome: A Prognostic Study by HELLINGS, Willem E, PEETERS, Wouter, VELEMA, Evelyn, DE KLEIJN, Dominique P. V, PASTERKAMP, Gerard, MOLL, Frans L, PIERS, Sebastiaan R. D, VAN SETTEN, Jessica, VAN DER SPEK, Peter J, DE VRIES, Jean-Paul P. M, SELDENRIJK, Kees A, DE BRUIN, Peter C, VINK, Aryan

“…Identification of patients at risk for primary and secondary manifestations of atherosclerotic disease progression is based mainly on established risk factors…”
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Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury by Lai, Ruenn Chai, Arslan, Fatih, Lee, May May, Sze, Newman Siu Kwan, Choo, Andre, Chen, Tian Sheng, Salto-Tellez, Manuel, Timmers, Leo, Lee, Chuen Neng, El Oakley, Reida Menshawe, Pasterkamp, Gerard, de Kleijn, Dominique P V, Lim, Sai Kiang

“…Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion…”
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Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis by Kraaijvanger, Raisa, Janssen Bonás, Montse, Grutters, Jan C, Paspali, Ioanna, Veltkamp, Marcel, de Kleijn, Dominique P V, van Moorsel, Coline H M

“…Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ…”
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The innate immune response in reperfused myocardium by Timmers, Leo, Pasterkamp, Gerard, de Hoog, Vince C, Arslan, Fatih, Appelman, Yolande, de Kleijn, Dominique P V

“…One of the major therapeutic challenges in the arena of interventional cardiology is to design strategies aimed at reducing myocardial tissue damage after…”
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Immunomodulation of the NLRP3 Inflammasome in Atherosclerosis, Coronary Artery Disease, and Acute Myocardial Infarction by Silvis, Max J. M., Demkes, Evelyne J., Fiolet, Aernoud T. L., Dekker, Mirthe, Bosch, Lena, van Hout, Gerardus P. J., Timmers, Leo, de Kleijn, Dominique P. V.

“…Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity worldwide. Atherosclerosis is responsible for the majority of cardiovascular…”
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