Search Results - "de Kleijn, D P"

Role of Toll-like receptor 4 in the initiation and progression of atherosclerotic disease by Pasterkamp, G., Van Keulen, J. K., De Kleijn, D. P. V.

“…The family of Toll‐like receptors (TLRs) initiates an innate immune response after recognition of pathogen‐associated molecular patterns (PAMPs). Evidence is…”
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The Coronary Sinus Reducer; 5-year Dutch experience by Silvis, M. J. M., Dekker, M., Zivelonghi, C., Agostoni, P., Stella, P. R., Doevendans, P. A., de Kleijn, D. P. V., van Kuijk, J. P., Leenders, G. E., Timmers, L.

“…Background Refractory angina is a growing and major health-care problem affecting millions of patients with coronary artery disease worldwide. The Coronary…”
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Carotid Atherosclerotic Plaques Stabilize After Stroke: Insights Into the Natural Process of Atherosclerotic Plaque Stabilization by Peeters, W, Hellings, W E., de Kleijn, D P.V., de Vries, J P.P.M., Moll, F L., Vink, A, Pasterkamp, G

“…Rupture of unstable atherosclerotic plaques is the pathological substrate for acute ischemic events. Underlying cellular and molecular characteristics of…”
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Heart failure with preserved ejection fraction in women: the Dutch Queen of Hearts program by den Ruijter, H., Pasterkamp, G., Rutten, F. H., Lam, C. S. P., Chi, C., Tan, K. H., van Zonneveld, A. J., Spaanderman, M., de Kleijn, D. P. V.

“…Heart failure (HF) poses a heavy burden on patients, their families and society. The syndrome of HF comes in two types: with reduced ejection fraction (HFrEF)…”
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Identification of genes potentially involved in disease transformation of CML by JANSSEN, J. J. W. M, KLAVER, S. M, WAISFISZ, Q, PASTERKAMP, G, DE KLEIJN, D. P. V, SCHUURHUIS, G. J, OSSENKOPPELE, G. J

“…In patients with chronic myeloid leukemia (CML) who do not reach a (near) complete cytogenetic response, the disease progresses over several years from an…”
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The ethnicity-specific association of biomarkers with the angiographic severity of coronary artery disease by Gijsberts, C. M., Seneviratna, A., Bank, I. E. M., den Ruijter, H. M., Asselbergs, F. W., Agostoni, P., Remijn, J. A., Pasterkamp, G., Kiat, H. C., Roest, M., Richards, A. M., Chan, M. Y., de Kleijn, D. P. V., Hoefer, I. E.

“…Background Risk factor burden and clinical characteristics of patients with coronary artery disease (CAD) differ among ethnic groups. We related biomarkers to…”
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Monocyte toll-like receptor 2 and 4 responses and expression following percutaneous coronary intervention: association with lesion stenosis and fractional flow reserve by Versteeg, D, Hoefer, I E, Schoneveld, A H, de Kleijn, D P V, Busser, E, Strijder, C, Emons, M, Stella, P R, Doevendans, P A, Pasterkamp, G

“…Toll-like receptors (TLRs) are key players in innate immunity and are causally related to arterial occlusive disease and arterial remodelling. The release of…”
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Increased amount of bone marrow-derived smooth muscle-like cells and accelerated atherosclerosis in diabetic apoE-deficient mice by Fledderus, J.O, van Oostrom, O, de Kleijn, D.P.V, den Ouden, K, Penders, A.F, Gremmels, H, de Bree, P, Verhaar, M.C

“…Abstract Aims Atherosclerotic plaque development is accelerated in patients with diabetes. Bone marrow-derived smooth muscle-like cells have been detected in…”
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Expression of the crustacean hyperglycaemic hormones and the gonad-inhibiting hormone during the reproductive cycle of the female American lobster Homarus americanus by de Kleijn, DP, Janssen, KP, Waddy, SL, Hegeman, R, Lai, WY, Martens, GJ, Van Herp, F

“…Crustacean reproduction is regulated by a complex chain of hormonal interactions in which the crustacean hyperglycaemic hormones A and B (CHH-A and CHH-B) and…”
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Activation of the innate immune system in atherosclerotic disease by Oude Nijhuis, M M, van Keulen, J K, Pasterkamp, G, Quax, P H, de Kleijn, D P V

“…Innate immunity is the first line of defence against invading micro-organisms. The family of Toll-like receptors (TLRs) recognizes pathogen-associated…”
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Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness by Schoneveld, A.H, Hoefer, I, Sluijter, J.P.G, Laman, J.D, de Kleijn, D.P.V, Pasterkamp, G

“…Abstract Background Toll like receptors (TLR) have been recognized for their role in atherosclerotic lesion development and progression. Endogenous TLR ligands…”
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Plasma extracellular vesicle protein content for diagnosis and prognosis of global cardiovascular disease by Wang, J. W., Gijsberts, C. M., Seneviratna, A., de Hoog, V. C., Vrijenhoek, J. E. P., Schoneveld, A. H., Chan, M. Y., Lam, C. S. P., Richards, A. M., Lee, C. N., Mosterd, A., Sze, S. K., Timmers, L., Lim, S. K., Pasterkamp, G., de Kleijn, D. P. V.

“…Cardiovascular disease is a major public health problem worldwide. Its growing burden is particularly ominous in Asia, due to increasing rates of major risk…”
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Predictive Risk Factors for Restenosis after Remote Superficial Femoral Artery Endarterectomy by Derksen, W.J.M, Gisbertz, S.S, Hellings, W.E, Vink, A, de Kleijn, D.P.V, de Vries, J.-P.P.M, Moll, F.L, Pasterkamp, G

“…Abstract Objectives Restenosis following remote superficial femoral artery endarterectomy (RSFAE) remains a challenging problem. The determinants predicting…”
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Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development by SCHONEVELD, A. H, OUDE NIJHUIS, M. M, VAN MIDDELAAR, B, LAMAN, J. D, DE KLEIJN, D. P. V, PASTERKAMP, G

“…Toll like receptors (Tlr) are essential in activation of the innate immune system. We recently described that peptidoglycan, an exogenous Tlr2 specific ligand,…”
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Arterial remodeling in atherosclerosis, restenosis and after alteration of blood flow : potential mechanisms and clinical implications by PASTERKAMP, G, DE KLEIJN, D. P. V, BORST, C

“…Arterial remodeling is currently being recognized as an important determinant in vascular pathology in which narrowing of the lumen is the predominant feature…”
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Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients by van Leeuwen, Fred W., Dominique P. V. de Kleijn, van den Hurk, Helma H., Neubauer, Andrea, Marc A. F. Sonnemans, Sluijs, Jacqueline A., Köycü, Soner, Ravindra D. J. Ramdjielal, Salehi, Ahmad, Gerard J. M. Martens, Grosveld, Frank G., J. Peter H. Burbach, Hol, Elly M.

“…The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the presence of protein deposits in neurofibrillary tangles, neuritic…”
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Plaque Biology, Realizing the Clinical Potential by Hellings, W.E, Pasterkamp, G, de Vries, J.-P, de Kleijn, D.P.V, Moll, F.L

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New Predictors of Adverse Cardiovascular Events Following Vascular Surgery by van Lammeren, G.W., de Vries, J. P. P. M, Vink, A., de Kleijn, D.P.V., Moll, F.L., Pasterkamp, G.

“…With the aging population and the increasing number of patients suffering from diabetes, the incidence of clinical manifestations of atherosclerotic disease is…”
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Tobacco smoking upregulates CRLF1 expression in the atherosclerotic lesions in sex- and plaque-type specific manner by Lan, T, De Kleijn, D P V, Den Ruijter, H M R, Pasterkamp, G P, Mokry, M M

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Carotid atherosclerotic plaque characteristics are associated with microembolization during carotid endarterectomy and procedural outcome by VERHOEVEN, B. A. N, DE VRIES, J. P. P. M, PASTERKAMP, G, ACKERSTAFF, R. G. A, SCHONEVELD, A. H, VELEMA, E, DE KLEIJN, D. P. V, MOLL, F. L

“…During carotid endarterectomy (CEA), microemboli may occur, resulting in perioperative adverse cerebral events. The objective of the present study was to…”
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