Search Results - "de Kier JoffÉ, Elisa Bal"

Contribution of individual PKC isoforms to breast cancer progression by Urtreger, Alejandro J., Kazanietz, Marcelo G., Bal de Kier Joffé, Elisa D.

“…The protein kinase C (PKC) family of serine/threonine kinases has been intensively studied in cancer since their discovery as major receptors for the…”
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Breast cancer stem cells are involved in Trastuzumab resistance through the HER2 modulation in 3D culture by Rodríguez, Cristina E., Berardi, Damian E., Abrigo, Marianela, Todaro, Laura B., Bal de Kier Joffé, Elisa D., Fiszman, Gabriel L.

“…Breast cancer human cells culture as spheroids develop autophagy and apoptosis, which promotes Trastuzumab resistance in HER2 overexpressing cells. Our aim was…”
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Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments by Blidner, Ada G, Salatino, Mariana, Mascanfroni, Ivan D, Diament, Miriam J, Bal de Kier Joffé, Elisa, Jasnis, Maria A, Klein, Slobodanka M, Rabinovich, Gabriel A

“…Myeloid-derived suppressor cells (MDSCs) are key regulatory cells that control inflammation and promote tumor-immune escape. To date, no specific…”
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Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids by Rodríguez, Cristina E, Reidel, Sara I, Bal de Kier Joffé, Elisa D, Jasnis, Maria A, Fiszman, Gabriel L

“…Multicellular tumor spheroids represent a 3D in vitro model that mimics solid tumor essential properties including assembly and development of extracellular…”
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Alteration of serum and tumoral neural cell adhesion molecule (NCAM) isoforms in patients with brain tumors by Todaro, Laura, Christiansen, Silvia, Varela, Mirta, Campodónico, Paola, Pallotta, M Guadalupe, Lastiri, José, Sacerdote de Lustig, Eugenia, Bal de Kier Joffé, Elisa, Puricelli, Lydia

“…The neural cell adhesion molecule (NCAM) is involved in the intercellular junctions of neurons and glial cells. We investigated its relevance as a biomarker in…”
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The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin by Pontiggia, Osvaldo, Sampayo, Rocio, Raffo, Diego, Motter, Andrea, Xu, Ren, Bissell, Mina J., de Kier Joffé, Elisa Bal, Simian, Marina

“…Tamoxifen resistance has been largely attributed to genetic alterations in the epithelial tumor cells themselves, such as overexpression of HER-2/Neu. However,…”
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The neural cell adhesion molecule is involved in the metastatic capacity in a murine model of lung cancer by Campodónico, Paola B., de Kier Joffé, Elisa D. Bal, Urtreger, Alejandro J., Lauria, Lilia S., Lastiri, José M., Puricelli, Lydia I., Todaro, Laura B.

“…Neural cell adhesion molecule (NCAM) is involved in cell growth, migration, and differentiation. Its expression and/or polysialylation appear to be deregulated…”
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Therapeutic blockade of Foxp3 in experimental breast cancer models by Moreno Ayala, Mariela A., Gottardo, María Florencia, Imsen, Mercedes, Asad, Antonela S., Bal de Kier Joffé, Elisa, Casares, Noelia, Lasarte, Juan José, Seilicovich, Adriana, Candolfi, Marianela

“…Purpose Regulatory T cells (Tregs) impair the clinical benefit of cancer immunotherapy. To optimize the antitumor efficacy of therapeutic dendritic cell (DC)…”
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TGF-β autocrine pathway and MAPK signaling promote cell invasiveness and in vivo mammary adenocarcinoma tumor progression by DAROQUI, MARÍA CECILIA, VAZQUEZ, PAULA, DE KIER JOFFÉ, ELISA BAL, BAKIN, ANDREI V, PURICELLI, LYDIA I

“…Breast cancer progression and metastasis have been linked to abnormal signaling by transforming growth factor-β (TGF-β) cytokines. In early-stage breast…”
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EGF-R and PDGF-R, but not bcl-2, overexpression predict overall survival in patients with low-grade astrocytomas by Varela, Mirta, Ranuncolo, Stella Maris, Morand, Ana, Lastiri, José, Joffé, Elisa Bal De Kier, Puricelli, Lydia Inés, Pallotta, María Guadalupe

“…Background and Objectives Therapy of malignant glioma tumors is based on histology and clinical factors. However, comparable lesions may correspond with…”
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Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential by URTREGER, Alejandro J, WERBAJH, Santiago E, VERRECCHIA, Frank, MAUVIEL, Alain, PURICELLI, Lydia I, KORNBLIHTT, Alberto R, DE KIER JOFFE, Elisa D. Bal

“…In the present work we used a murine mammary cancer model of two related adenocarcinomas with different lung metastasizing abilities, to compare their global…”
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N4‐aryl substituted thiosemicarbazones derived from 1‐indanones as potential anti‐tumor agents for breast cancer treatment by Sólimo, Aldana, Soraires Santacruz, Maria Cristina, Loaiza Perez, Andrea I., Bal de Kier Joffé, Elisa, Finkielsztein, Liliana M., Callero, Mariana A.

“…Breast cancer is the first cause of cancer death in women. Many patients are resistant to current therapies, and even those were sensitive at first may…”
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Progestin Effects on Breast Cancer Cell Proliferation, Proteases Activation, and in Vivo Development of Metastatic Phenotype All Depend on Progesterone Receptor Capacity to Activate Cytoplasmic Signaling Pathways by Carnevale, Romina P, Proietti, Cecilia J, Salatino, Mariana, Urtreger, Alejandro, Peluffo, Guillermo, Edwards, Dean P, Boonyaratanakornkit, Viroj, Charreau, Eduardo H, de Kier Joffé, Elisa Bal, Schillaci, Roxana, Elizalde, Patricia V

“…Accumulating evidence indicates that progestins are involved in controlling mammary gland tumorigenesis. Here, we assessed the molecular mechanisms of…”
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Protein kinase C δ enhances proliferation and survival of murine mammary cells by Grossoni, Valeria C., Falbo, Karina B., Kazanietz, Marcelo G., de Kier Joffé, Elisa D. Bal, Urtreger, Alejandro J.

“…Protein kinase C (PKC) δ, a member of the novel family of PKC serine‐threonine kinases, has been implicated in negative regulation of proliferation and…”
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Pharmacological Strategies in Lung Cancer-Induced Cachexia: Effects on Muscle Proteolysis, Autophagy, Structure, and Weakness by Chacon-Cabrera, Alba, Fermoselle, Clara, Urtreger, Alejandro J., Mateu-Jimenez, Mercè, Diament, Miriam J., de Kier Joffé, Elisa D. Bal, Sandri, Marco, Barreiro, Esther

“…ABSTRACT Cachexia is a relevant comorbid condition of chronic diseases including cancer. Inflammation, oxidative stress, autophagy, ubiquitin–proteasome…”
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Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells by Castillo, Lilian Fedra, Tascón, Rocío, Lago Huvelle, María Amparo, Novack, Gisela, Llorens, María Candelaria, Dos Santos, Ancely Ferreira, Shortrede, Jorge, Cabanillas, Ana María, Bal de Kier Joffé, Elisa, Labriola, Leticia, Peters, María Giselle

“…Breast cancer is the disease with the highest impact on global health, being metastasis the main cause of death. To metastasize, carcinoma cells must…”
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Involvement of PKC delta (PKCδ) in the resistance against different doxorubicin analogs by Díaz Bessone, María Ines, Berardi, Damian E., Campodónico, Paola B., Todaro, Laura B., Lothstein, Leonard, Bal de Kier Joffé, Elisa D., Urtreger, Alejandro J.

“…Doxorubicin is an anti-tumor antibiotic widely used in the management of cancer patients. Its main mechanism of action involves the generation of DNA damage…”
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Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice by Fermoselle, Clara, García‐Arumí, Elena, Puig‐Vilanova, Ester, Andreu, Antoni L., Urtreger, Alejandro J., de Kier Joffé, Elisa D. Bal, Tejedor, Alberto, Puente‐Maestu, Luís, Barreiro, Esther

“…New Findings •  What is the central question of this study? We explored whether experimental cancer‐induced cachexia may alter mitochondrial respiratory chain…”
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The synthetic peptide CIGB-300 modulates CK2-dependent signaling pathways affecting the survival and chemoresistance of non-small cell lung cancer cell lines by Cirigliano, Stéfano M, Díaz Bessone, María I, Berardi, Damián E, Flumian, Carolina, Bal de Kier Joffé, Elisa D, Perea, Silvio E, Farina, Hernán G, Todaro, Laura B, Urtreger, Alejandro J

“…Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths worldwide. Up to 80% of cancer patients are classified as…”
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Glucocorticoid alternative effects on proliferating and differentiated mammary epithelium are associated to opposite regulation of cell-cycle inhibitor expression by Hoijman, Esteban, Rocha-Viegas, Luciana, Kalko, Susana G., Rubinstein, Natalia, Morales-Ruiz, Manuel, Joffé, Elisa Bal de Kier, Kordon, Edith C., Pecci, Adali

“…Glucocorticoids influence post‐natal mammary gland development by sequentially controlling cell proliferation, differentiation, and apoptosis. In the mammary…”
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