Search Results - "de Jonge, R."
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Early weight measures and long-term neuropsychological outcome of critically ill neonates and infants: a secondary analysis of the PEPaNIC trial
Published in European journal of pediatrics (01-02-2024)“…Neonates and infants surviving critical illness show impaired growth during critical illness and are at risk for later neuropsychological impairments. Early…”
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Scaffolds obtained from decellularized human extrahepatic bile ducts support organoids to establish functional biliary tissue in a dish
Published in Biotechnology and bioengineering (01-02-2021)“…Biliary disorders can lead to life‐threatening disease and are also a challenging complication of liver transplantation. As there are limited treatment…”
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Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia
Published in PloS one (18-05-2020)“…We have recently established a protocol to grow wildtype human oral mucosa organoids. These three-dimensional structures can be maintained in culture…”
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Association between shockable rhythms and long-term outcome after pediatric out-of-hospital cardiac arrest in Rotterdam, the Netherlands: An 18-year observational study
Published in Resuscitation (01-09-2021)“…Shockable rhythm following pediatric out-of-hospital cardiac arrest (pOHCA) is consistently associated with hospital and short-term survival. Little is known…”
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Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease
Published in Scientific reports (21-04-2022)“…Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene. Defective CFTR leads to accumulation of…”
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Trends in community response and long-term outcomes from pediatric cardiac arrest: A retrospective observational study
Published in Resuscitation (01-01-2024)“…This study aimed to investigate trends over time in pre-hospital factors for pediatric out-of-hospital cardiac arrest (pOHCA) and long-term neurological and…”
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Less meat in the shopping basket. The effect on meat purchases of higher prices, an information nudge and the combination: a randomised controlled trial
Published in BMC public health (07-06-2022)“…Reduced meat consumption benefits human and planetary health. Modelling studies have demonstrated the significant health and environmental gains that could be…”
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Study protocol: The Dutch 20|30 Postmeningitis study: a cross-sectional follow-up of two historical childhood bacterial meningitis cohorts on long-term outcomes
Published in BMC pediatrics (30-12-2019)“…Bacterial meningitis (BM) is a serious, life-threatening infectious disease of the central nervous system that often occurs in young children. The most common…”
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Cutaneous microcirculation in preterm neonates: comparison between sidestream dark field (SDF) and incident dark field (IDF) imaging
Published in Journal of clinical monitoring and computing (01-10-2015)“…Incident dark field imaging (IDF) is a new generation handheld microscope for bedside visualization and quantification of microcirculatory alterations. IDF is…”
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Measuring methotrexate polyglutamates in red blood cells: a new LC-MS/MS-based method
Published in Analytical and bioanalytical chemistry (01-02-2013)“…The folate antagonist methotrexate (MTX) is the anchor drug in the treatment of rheumatoid arthritis. The therapeutic effects of MTX are attributed to the…”
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Early hypophosphatemia in critically ill children and the effect of parenteral nutrition: A secondary analysis of the PEPaNIC RCT
Published in Clinical nutrition (Edinburgh, Scotland) (01-11-2022)“…Hypophosphatemia during critical illness has been associated with adverse outcome. The reintroduction of enteral or parenteral nutrition, leading to refeeding…”
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Making knowledge clips with patients: What learning mechanisms are triggered in medical students?
Published in Patient education and counseling (01-10-2022)“…To prepare medical students for a rapidly changing healthcare landscape, where new means of communication emerge, innovative teaching methods are needed. We…”
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Specific Regulatory Motifs Predict Glucocorticoid Responsiveness of Hippocampal Gene Expression
Published in Endocrinology (Philadelphia) (01-10-2011)“…The glucocorticoid receptor (GR) is an ubiquitously expressed ligand-activated transcription factor that mediates effects of cortisol in relation to adaptation…”
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Comparative phenomics and targeted use of genomics reveals variation in carbon and nitrogen assimilation among different Brettanomyces bruxellensis strains
Published in Applied microbiology and biotechnology (01-11-2015)“…Recent studies have suggested a correlation between genotype groups of Brettanomyces bruxellensis and their source of isolation. To further explore this…”
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Exploring solutions for healthy, safe, and sustainable fatty acids (EPA and DHA) consumption in The Netherlands
Published in Sustainability science (01-03-2019)“…Advisory bodies such as the World Health Organization and the Dutch Health Council (DHC) recommend including fatty fish in one’s diet, based on the health…”
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Folding of CFTR Is Predominantly Cotranslational
Published in Molecular cell (28-10-2005)“…The folding process for newly synthesized, multispanning membrane proteins in the endoplasmic reticulum (ER) is largely unknown. Here, we describe early…”
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Subcutaneous administration, higher age and lower renal function are associated with erythrocyte methotrexate accumulation in Crohn’s disease: a cross-sectional study
Published in BMC gastroenterology (30-07-2022)“…Abstract Background Methotrexate is an immunomodulatory drug for patients with Crohn’s disease. Erythrocyte MTX-polyglutamates (MTX-PG 1-5 ) may be used for…”
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Correction: Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia
Published in PloS one (05-08-2020)“…[This corrects the article DOI: 10.1371/journal.pone.0231588.]…”
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A functional CFTR assay using primary cystic fibrosis intestinal organoids
Published in Nature medicine (01-07-2013)“…Building on earlier work, Dekkers et al . describe the first application of their intestinal organoid culture technology to the study of human disease, in this…”
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