Search Results - "de Jonge, H.R"

Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances by Tilly, B.C, Berghe, N. van den, Tertoolen, L.G.J, Edixhoven, M.J, Jonge, H.R. de

“…Using the human Intestine 407 cell line as a model, we investigated a possible role for tyrosine kinase(s) in regulating the ion efflux pathways induced by…”
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New clinical diagnostic procedures for cystic fibrosis in Europe by De Boeck, K, Derichs, N, Fajac, I, de Jonge, H.R, Bronsveld, I, Sermet, I, Vermeulen, F, Sheppard, D.N, Cuppens, H, Hug, M, Melotti, P, Middleton, P.G, Wilschanski, M

“…Abstract In the majority of cases, there is no difficulty in diagnosing Cystic Fibrosis (CF). However, there may be wide variation in signs and symptoms…”
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Assessment of CFTR function in homozygous R117H-7T subjects by de Nooijer, R.A, Nobel, J.M, Arets, H.G.M, Bot, A.G, van Berkhout, F. Teding, de Rijke, Y.B, de Jonge, H.R, Bronsveld, I

“…Abstract Background R117H is a frequent missense mutation included in most CFTR mutation panels. However knowledge about the residual function of R117H-CFTR…”
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272 Ursodeoxycholate reduces cholate biosynthesis rate and pool size in Cftr−/− mice by Bodewes, F.A.J.A, Wouthuyzen-Bakker, M, Bijvelds, M, de Jonge, H.R, Verkade, H.J

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WS14.5 A functional CFTR assay using primary cystic fibrosis intestinal organoids by Dekkers, J.F, Wiegerinck, C.L, de Jonge, H.R, de Jong, N.W.M, Bijvelds, M.J.C, Nieuwenhuis, E.E.S, van den Brink, S, Clevers, H, van der Ent, C.K, Middendorp, S

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R117H homozygosity and the genotype–phenotype relationship by Bronsveld, I, de Nooijer, R.A, Arets, H.G.M, van Berkhout, F. Teding, van der Ent, C.K, de Rijke, Y, de Jonge, H.R

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ePS6.02 CFTR modulators improve bicarbonate transport via the CFTR variant D1152H (c.3453G>C) in primary human intestinal epithelial cells by Angyal, D., Bijvelds, M.J.C., Bruno, M.J., Peppelenbosch, M.P., Beekman, J.M., Melotti, P., Kleinfelder, K., Sorio, C., de Jonge, H.R.

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Heat-stable enterotoxin receptor/guanylyl cyclase C is an oligomer consisting of functionally distinct subunits, which are non-covalently linked in the intestine by VAANDRAGER, A. B, VAN DER WIEL, E, HOM, M. L, LUTHJENS, L. H, DE JONGE, H. R

“…Guanylyl cyclase (GC) C is a heat-stable enterotoxin (STa) receptor with a monomeric M(r) of approximately 140,000. We calculated from its hydrodynamic…”
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Targeted locus amplification reveals heterogeneity between and within CFTR genotypes and association with CFTR function in patient-derived intestinal organoids by Lefferts, J.W., Boersma, V., Nieuwenhuijze, N.D.A., Suen, S.W.F., Hajo, K., Collantes, N. Sanchez, Vermeulen, C., Groeneweg, T., Hagemeijer, M.C., de Jonge, H.R., van der Ent, C.K., Splinter, E., Beekman, J.M.

“…•Targeted locus amplification (TLA) allows for the allele-specific analysis of the complete CFTR gene.•Paired TLA and functional CFTR measurements in…”
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ePS1.04 In vivo effect of three potentiator treatments found effective in rectal organoids by Berkers, G., van Mourik, P., Vonk, A.M., Kruisselbrink, E., Dekkers, J.F., de Winter - de Groot, K.M., Arets, H.G.M., Heijerman, H., Majoor, C.J., Koppelman, G.H., Roukema, J., Janssens, H.M., van der Meer, R., Vries, R.G.J., de Jonge, H.R., Beekman, J.M., van der Ent, C.K.

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The localization of guanylate cyclase in rat small intestinal epithelium by De Jonge, H.R.

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Internal exposure of rats to benzidine derived from orally administered benzidine-based dyes after intestinal azo reduction by Bos, R P, van der Krieken, W, Smeijsters, L, Koopman, J P, de Jonge, H R, Theuws, J L, Henderson, P T

“…The role of the rat intestinal flora in the azo reduction of some benzidine-based dyes was studied in vitro and in vivo. The formation of benzidine was…”
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Kinetic evidence for the presence of two forms of M2-type pyruvate kinase in rat small intestine by van Berkel, T J, de Jonge, H R, Koster, J F, Hülsmann, W C

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Guanylyl cyclase C is an N-linked glycoprotein receptor that accounts for multiple heat-stable enterotoxin-binding proteins in the intestine by VAANDRAGER, A. B, SCHULZ, S, DE JONGE, H. R, GARBERS, D. L

“…Guanylyl cyclase C (GC-C) is a newly discovered receptor found in the intestine, and possibly in other epithelia, that binds bacterial heat-stable enterotoxins…”
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Heat-stable enterotoxin activation of immunopurified guanylyl cyclase C. Modulation by adenine nucleotides by VAANDRAGER, A. B, VAN DER WIEL, E, DE JONGE, H. R

“…We studied the activation and inactivation of recombinant guanylyl cyclase (GC) C stably expressed in human kidney 293 cells. Activation of GC-C by heat-stable…”
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Immunological localization of cystic fibrosis candidate gene products by Hoogeveen, A T, Keulemans, J, Willemsen, R, Scholte, B J, Bijman, J, Edixhoven, M J, De Jonge, H R, Galjaard, H

“…The recent identification of the cystic fibrosis (CF) gene and its putative protein product, the CF transmembrane conductance regulator (CFTR), enabled us to…”
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Regulation of chloride transport in cultured normal and cystic fibrosis keratinocytes by Kansen, M, Keulemans, J, Hoogeveen, A T, Scholte, B, Vaandrager, A B, van der Kamp, A W, Sinaasappel, M, Bot, A G, de Jonge, H R, Bijman, J

“…Cultured normal (N) cystic fibrosis (CF) keratinocytes were evaluated for their Cl(-)-transport properties by patch-clamp-, Ussing chamber- and isotopic…”
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The response of small intestinal villous and crypt epithelium to choleratoxin in rat and guinea pig. Evidence against a specific role of the crypt cells in choleragen-induced secretion by De Jonge, H R

“…1. Some kinetic properties of adenylate cyclase in separately isolated upper villous and crypt cells from rat and guinea pig small intestine were compared. An…”
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Properties of guanylate cyclase and levels of cyclic GMP in rat small intestinal villous and crypt cells by de Jonge, H.R.

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Calcium and glucose uptake in rat small intestinal brush-border membrane vesicles. Modulation by exogenous hypercortisolism and 1,25-dihydroxyvitamin D-3 by Braun, H J, Birkenhäger, J C, De Jonge, H R

“…The effect of exogenous hypercortisolism and 1,25-dihydroxyvitamin D-3 on small-intestinal calcium and glucose transport in the rat was studied at the level of…”
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