Search Results - "de Jong, Susan"

Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN by de Jong, Susan, Chikh, Ghania, Sekirov, Laura, Raney, Sam, Semple, Sean, Klimuk, Sandra, Yuan, Ning, Hope, Micheal, Cullis, Pieter, Tam, Ying

“…Immunostimulatory oligodeoxynucleotides (ODN) containing cytosine-guanine (CpG) motifs are powerful stimulators of innate as well as adaptive immune responses,…”
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Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles by Chikh, Ghania, de Jong, Susan D., Sekirov, Laura, Raney, Sameersingh G., Kazem, Mikameh, Wilson, Kaley D., Cullis, Pieter R., Dutz, Jan P., Tam, Ying K.

“…Although it is well documented that the immunological activity of cytosine–guanine (CpG) motifs is abrogated by 5′ methylation of the cytosine residue,…”
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Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study by Geisbert, Thomas W, Prof, Lee, Amy CH, MSc, Robbins, Marjorie, PhD, Geisbert, Joan B, Honko, Anna N, PhD, Sood, Vandana, MSc, Johnson, Joshua C, BSc, de Jong, Susan, PhD, Tavakoli, Iran, BSc, Judge, Adam, PhD, Hensley, Lisa E, PhD, MacLachlan, Ian, PhD

“…Summary Background We previously showed that small interfering RNAs (siRNAs) targeting the Zaire Ebola virus (ZEBOV) RNA polymerase L protein formulated in…”
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Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy by Wilson, Kaley D., de Jong, Susan D., Tam, Ying K.

“…There has been significant interest in the potential of cytosine–guanine (CpG) containing oligodeoxynucleotides (ODN) as an immunotherapy for malignant,…”
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The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine by Wilson, Kaley D., de Jong, Susan D., Kazem, Mikameh, Lall, Ryan, Hope, Michael J., Cullis, Pieter R., Tam, Ying K.

“…Background DNA vaccines offer unique potential for generating protective and therapeutic immunity against infectious and malignant diseases. Unfortunately,…”
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The immunostimulatory activity of unmethylated and methylated CpG oligodeoxynucleotide is dependent on their ability to colocalize with TLR9 in late endosomes by de Jong, Susan D, Basha, Genc, Wilson, Kaley D, Kazem, Mikameh, Cullis, Pieter, Jefferies, Wilf, Tam, Ying

“…TLR9 recognizes CpG motifs present in pathogenic DNA and triggers potent immune responses. It is generally accepted that TLR9 distinguishes pathogenic DNA…”
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The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN by Raney, Sameersingh G., Wilson, Kaley D., Sekirov, Laura, Chikh, Ghania, de Jong, Susan D., Cullis, Pieter R., Tam, Ying K.

“…The encapsulation of conventional drugs in lipid nanoparticles (LNs) has been extensively utilized to enhance therapeutic activity by altering their…”
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Easy 250 EasySep&[trade] Magnet: A Novel Magnetic Platform For Large-Volume CD34+ Hematopoietic Stem and Progenitor Cell Isolation from Leukapheresis Products by Morin, Peter, Toombs, Eric, MacDonald, Neil, Eaves, Allen C., Louis, Sharon A., Kokaji, Andy I., de Jong, Susan

“…Abstract We have developed a novel magnetic platform for large-volume CD34+ hematopoietic stem and progenitor cell (HPSC) isolation from both mobilized and…”
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EasySep&[trade] T75 Magnet: A Novel Magnetic Platform for Large-Volume Cell Isolation from Whole Blood and Leukapheresis Packs by MacDonald, G. Neil, Toombs, Eric, de Jong, Susan, McQueen, Karina L, Eaves, Allen C, Louis, Sharon A., Kokaji, Andy I

“…Abstract Isolating cells from large volume-samples such as leukapheresis or whole blood bags is a common procedure that precedes many immunological studies…”
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Quick and Easy Isolation of Immune Cells From Large-Volume Samples by Posarac, Vesna, MacDonald, G Neil, Buck, Chris A., Toombs, Eric, Gellner, Savannah D., de Jong, Susan, Williamson, Mark E., Egeler, Oliver, Dalton, Bob, Kokaji, Andy I., Eaves, Allen C., Louis, Sharon A., Antignano, Frann

“…Abstract Large-scale cell isolation is commonly performed in labs and core facilities for cell banking and drug discovery, and as a critical step in cell…”
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Fast and easy immunomagnetic positive selection of PE- or biotin-conjugated antibody-labelled cells with Releasable Rapidspheres results in highly purified, functional and particle-free cells by Ewen, Catherine, Kokaji, Andy I, Clarke, Samuel J, Lambertz, Ulrike, De Jong, Susan, Woodside, Steven M

“…Abstract Immunomagnetic cell isolation is a cost-effective and gentle method of obtaining purified cell populations. However, isolating novel or rare cell…”
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Fast and easy immunomagnetic isolation of untouched human naïve T cells in less than 15 minutes by Ewen, Catherine, MacDonald, Neil, de Jong, Susan, Kokaji, Andy I., Woodside, Steven M., Eaves, Allen C., Thomas, Terry E.

“…Abstract Peripheral blood circulating T cells can be subdivided into either antigen experienced effector and memory T cells or naïve T cells that have not yet…”
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Easy, column-free procedure for the enrichment of human Th1 cells from peripheral blood (P3239) by Fairhurst, Maureen, Yu, Jessie, de Jong, Susan, Thomas, Terry

“…Abstract Upon activation naïve T helper (Th) precursor cells are polarized toward various cell subtypes and can be distinguished from each other based on…”
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Rapid, simple, column-free isolation of CD11b+ cells from various mouse organs (INC6P.323) by Valdez, Yanet, Tabatabaei-Zavareh, Nooshin, de Jong, Susan, Morin, Peter, Karas, Evan, Kollar, Anita, Fairhurst, Maureen, Eaves, Allen, Thomas, Terry

“…Abstract CD11b+ cells are distributed throughout the body and act as sentinels for the immune system. The frequency of CD11b+ myeloid cells varies in different…”
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Postexposure protection of non-human primates against a lethal Ebola virus challenge withA interference: a proof-of-concept study by Geisbert, Thomas W, Lee, Amy CH, Robbins, Marjorie, Geisbert, Joan B, Honko, Anna N, Sood, Vandana, Johnson, Joshua C, De Jong, Susan, Tavakoli, Iran, Judge, Adam, Hensley, Lisa E, MacLachlan, Ian

“…We previously showed that small interferingAs (siRNAs) targeting the Zaire Ebola virus (ZEBOV)A polymerase L protein formulated in stable nucleic acid-lipid…”
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Abstract B204: Development of ALN-VSP: An RNAi therapeutic for liver malignancies by Toudjarska, Iva, Judge, Adam, Buck, Tim, McClintock, Kevin, de Jong, Susan, Ambegia, Ellen, Brodsky, Joshua, Akinc, Akin, Racie, Timothy, Jeffs, Lloyd, Yaworski, Ed, MacLachlan, Ian, Sah, Dinah W., Gollob, Jared, Bumcrot, David A.

“…Abstract Malignancies of the liver, including primary (hepatocellular carcinoma) and secondary (metastatic) tumors, represent a significant unmet medical need…”
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Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy: CpG Oligonucleotides as Immunotherapeutic Adjuvants: Innovative Applications and Delivery Strategies by WILSON, Kaley D, DE JONG, Susan D, TAM, Ying K

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