Search Results - "de Jong, Simone"

Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects by van Eijk, Kristel R, de Jong, Simone, Boks, Marco P M, Langeveld, Terry, Colas, Fabrice, Veldink, Jan H, de Kovel, Carolien G F, Janson, Esther, Strengman, Eric, Langfelder, Peter, Kahn, René S, van den Berg, Leonard H, Horvath, Steve, Ophoff, Roel A

“…The predominant model for regulation of gene expression through DNA methylation is an inverse association in which increased methylation results in decreased…”
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Distinct Effects of Heparin and Interleukin‐4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats by Bonito, Valentina, Koch, Suzanne E., Krebber, Merle M., Carvajal‐Berrio, Daniel A., Marzi, Julia, Duijvelshoff, Renee, Lurier, Emily B., Buscone, Serena, Dekker, Sylvia, Jong, Simone M. J., Mes, Tristan, Vaessen, Koen R. D., Brauchle, Eva M., Bosman, Anton W., Schenke‐Layland, Katja, Verhaar, Marianne C., Dankers, Patricia Y. W., Smits, Anthal I. P. M., Bouten, Carlijn V. C.

“…Two of the greatest challenges for successful application of small‐diameter in situ tissue‐engineered vascular grafts are 1) preventing thrombus formation and…”
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A Supramolecular Platform for the Introduction of Fc-Fusion Bioactive Proteins on Biomaterial Surfaces by Putti, Matilde, de Jong, Simone M. J, Stassen, Oscar M. J. A, Sahlgren, Cecilia M, Dankers, Patricia Y. W

“…Bioorthogonal chemistry is an excellent method for functionalization of biomaterials with bioactive molecules, as it allows for decoupling of material…”
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Concerning the use of aminoglycosides in ventilator-associated pneumonia by de Jong, Simone Y M, Zijlstra, G Jan

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An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging by Yuan, Tian, Jiao, Yinming, de Jong, Simone, Ophoff, Roel A, Beck, Stephan, Teschendorff, Andrew E

“…Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may have deep implications for cellular differentiation and…”
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Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts by Zhang, Xianglong, Abdellaoui, Abdel, Rucker, James, de Jong, Simone, Potash, James B., Weissman, Myrna M., Shi, Jianxin, Knowles, James A., Pato, Carlos, Pato, Michele, Sobell, Janet, Smit, Johannes H., Hottenga, Jouke-Jan, de Geus, Eco J.C., Lewis, Cathryn M., Buttenschøn, Henriette N., Craddock, Nick, Jones, Ian, Jones, Lisa, McGuffin, Peter, Mors, Ole, Owen, Michael J., Preisig, Martin, Rietschel, Marcella, Rice, John P., Rivera, Margarita, Uher, Rudolf, Gejman, Pablo V., Sanders, Alan R., Boomsma, Dorret, Penninx, Brenda W.J.H., Breen, Gerome, Levinson, Douglas F.

“…Major depressive disorder (MDD) is moderately heritable, with a high prevalence and a presumed high heterogeneity. Copy number variants (CNVs) could contribute…”
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Biomaterial-driven kidney organoid maturation by van Sprang, Johnick F., de Jong, Simone M.J., Dankers, Patricia Y.W.

“…Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target…”
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A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes by de Jong, Simone, Boks, Marco P M, Fuller, Tova F, Strengman, Eric, Janson, Esther, de Kovel, Carolien G F, Ori, Anil P S, Vi, Nancy, Mulder, Flip, Blom, Jan Dirk, Glenthøj, Birte, Schubart, Chris D, Cahn, Wiepke, Kahn, René S, Horvath, Steve, Ophoff, Roel A

“…Despite large-scale genome-wide association studies (GWAS), the underlying genes for schizophrenia are largely unknown. Additional approaches are therefore…”
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Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells by de Lucia, Chiara, Murphy, Tytus, Maruszak, Aleksandra, Wright, Paul, Powell, Timothy R, Hartopp, Naomi, de Jong, Simone, O'Sullivan, Michael J, Breen, Gerome, Price, Jack, Lovestone, Simon, Thuret, Sandrine

“…Age-related alteration in neural stem cell function is linked to neurodegenerative conditions and cognitive decline. In rodents, this can be reversed by…”
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Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis by de Jong, Simone, Newhouse, Stephen J., Patel, Hamel, Lee, Sanghyuck, Dempster, David, Curtis, Charles, Paya-Cano, Jose, Murphy, Declan, Wilson, C. Ellie, Horder, Jamie, Mendez, M. Andreina, Asherson, Philip, Rivera, Margarita, Costello, Helen, Maltezos, Stefanos, Whitwell, Susannah, Pitts, Mark, Tye, Charlotte, Ashwood, Karen L., Bolton, Patrick, Curran, Sarah, McGuffin, Peter, Dobson, Richard, Breen, Gerome

“…Recent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology. To systematically investigate genomics overlap…”
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Associations between polygenic risk scores for four psychiatric illnesses and brain structure using multivariate pattern recognition by Ranlund, Siri, Rosa, Maria Joao, de Jong, Simone, Cole, James H., Kyriakopoulos, Marinos, Fu, Cynthia H.Y., Mehta, Mitul A., Dima, Danai

“…Psychiatric illnesses are complex and polygenic. They are associated with widespread alterations in the brain, which are partly influenced by genetic factors…”
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The polygenic risk for bipolar disorder influences brain regional function relating to visual and default state processing of emotional information by Dima, Danai, de Jong, Simone, Breen, Gerome, Frangou, Sophia

“…Genome-wise association studies have identified a number of common single-nucleotide polymorphisms (SNPs), each of small effect, associated with risk to…”
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Accurate and Fast Multiple-Testing Correction in eQTL Studies by Sul, Jae Hoon, Raj, Towfique, de Jong, Simone, de Bakker, Paul I.W., Raychaudhuri, Soumya, Ophoff, Roel A., Stranger, Barbara E., Eskin, Eleazar, Han, Buhm

“…In studies of expression quantitative trait loci (eQTLs), it is of increasing interest to identify eGenes, the genes whose expression levels are associated…”
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Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner by de Jong, Simone, Chepelev, Iouri, Janson, Esther, Strengman, Eric, van den Berg, Leonard H, Veldink, Jan H, Ophoff, Roel A

“…Chromosome 17q21.31 contains a common inversion polymorphism of approximately 900 kb in populations with European ancestry. Two divergent MAPT haplotypes, H1…”
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Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background by de Jong, Simone, Fuller, Tova F, Janson, Esther, Strengman, Eric, Horvath, Steve, Kas, Martien J H, Ophoff, Roel A

“…We performed gene expression profiling of the amygdala and hippocampus taken from inbred mouse strains C57BL/6J and A/J. The selected brain areas are…”
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Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes by DE JONG, Simone, VAN EIJK, Kristel R, OPHOFF, Roel A, ZEEGERS, Dave W. L. H, STRENGMAN, Eric, JANSON, Esther, VELDINK, Jan H, VAN DEN BERG, Leonard H, CAHN, Wiepke, KAHN, René S, BOKS, Marco P. M

“…There is genetic evidence that schizophrenia is a polygenic disorder with a large number of loci of small effect on disease susceptibility. Genome-wide…”
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Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations by Pjetri, Eneda, de Haas, Ria, de Jong, Simone, Gelegen, Cigdem, Oppelaar, Hugo, Verhagen, Linda A W, Eijkemans, Marinus J C, Adan, Roger A, Olivier, Berend, Kas, Martien J

“…Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric…”
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Characterization of genome-methylome interactions in 22 nuclear pedigrees by Plongthongkum, Nongluk, van Eijk, Kristel R, de Jong, Simone, Wang, Tina, Sul, Jae Hoon, Boks, Marco P M, Kahn, René S, Fung, Ho-Lim, Ophoff, Roel A, Zhang, Kun

“…Genetic polymorphisms can shape the global landscape of DNA methylation, by either changing substrates for DNA methyltransferases or altering the DNA binding…”
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Gestational Influenza Increases the Risk of Psychosis in Adults by Cai, Lei, Wan, Chun-Lin, He, Lin, de Jong, Simone, Chou, Kuo-Chen

“…Psychotic disorders are complex and caused by interplay of genetic and environmental factors. Influenza is a common infectious disease in humans, and it has…”
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Hippocampal gene expression analysis highlights Ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice by de Jong, Simone, Kas, Martien J H, Kiernan, Jeffrey, de Mooij-van Malsen, Annetrude G, Oppelaar, Hugo, Janson, Esther, Vukobradovic, Igor, Farber, Charles R, Stanford, William L, Ophoff, Roel A

“…In this study, we show that the covariance between behavior and gene expression in the brain can help further unravel the determinants of neurobehavioral…”
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