Search Results - "de Jong, Rob"

Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia by van der Lee, Dyantha I, Reijmers, Rogier M, Honders, Maria W, Hagedoorn, Renate S, de Jong, Rob Cm, Kester, Michel Gd, van der Steen, Dirk M, de Ru, Arnoud H, Kweekel, Christiaan, Bijen, Helena M, Jedema, Inge, Veelken, Hendrik, van Veelen, Peter A, Heemskerk, Mirjam Hm, Falkenburg, J H Frederik, Griffioen, Marieke

“…The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive…”
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Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 Increases Neovascularization and Blood Flow Recovery After Ischemia by Welten, Sabine M.J, Bastiaansen, Antonius J.N.M, de Jong, Rob C.M, de Vries, Margreet R, Peters, Erna A.B, Boonstra, Martin C, Sheikh, Søren P, Monica, Nicola La, Kandimalla, Ekambar R, Quax, Paul H.A, Nossent, A Yaël

“…RATIONALE:Effective neovascularization is crucial for recovery after cardiovascular events. OBJECTIVE:Because microRNAs regulate expression of up to several…”
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Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement by Ugurlar, Deniz, Howes, Stuart C, de Kreuk, Bart-Jan, Koning, Roman I, de Jong, Rob N, Beurskens, Frank J, Schuurman, Janine, Koster, Abraham J, Sharp, Thomas H, Parren, Paul W H I, Gros, Piet

“…Danger patterns on microbes or damaged host cells bind and activate C1, inducing innate immune responses and clearance through the complement cascade. How…”
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A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface by de Jong, Rob N, Beurskens, Frank J, Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D, Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J, Oostindie, Simone C, Wang, Guanbo, Heck, Albert J R, Schuurman, Janine, Parren, Paul W H I

“…IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1…”
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Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen by Wang, Guanbo, de Jong, Rob N., van den Bremer, Ewald T.J., Beurskens, Frank J., Labrijn, Aran F., Ugurlar, Deniz, Gros, Piet, Schuurman, Janine, Parren, Paul W.H.I., Heck, Albert J.R.

“…The classical complement pathway contributes to the natural immune defense against pathogens and tumors. IgG antibodies can assemble at the cell surface into…”
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The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development by de Jong, Rob C M, Ewing, Mark M, de Vries, Margreet R, Karper, Jacco C, Bastiaansen, Antonius J N M, Peters, Hendrika A B, Baghana, Fabiana, van den Elsen, Peter J, Gongora, Céline, Jukema, J Wouter, Quax, Paul H A

“…Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor…”
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Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response by de Jong, Rob C. M., Pluijmert, Niek J., de Vries, Margreet R., Pettersson, Knut, Atsma, Douwe E., Jukema, J. Wouter, Quax, Paul H. A.

“…Annexin A5 (AnxA5) is known to have anti-inflammatory and anti-apoptotic properties. Inflammation and apoptosis are key processes in post-ischemic cardiac…”
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Assessing hearing loss in older adults with a single question and person characteristics; Comparison with pure tone audiometry in the Rotterdam Study by Oosterloo, Berthe C, Homans, Nienke C, Baatenburg de Jong, Rob J, Ikram, M Arfan, Nagtegaal, A Paul, Goedegebure, André

“…Hearing loss (HL) is a frequent problem among the elderly and has been studied in many cohort studies. However, pure tone audiometry-the gold standard-is…”
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Using the Digits-In-Noise Test to Estimate Age-Related Hearing Loss by Koole, Arne, Nagtegaal, A. Paul, Homans, Nienke C., Hofman, Albert, Baatenburg de Jong, Rob J., Goedegebure, André

“…OBJECTIVE:Age-related hearing loss is common in the elderly population. Timely detection and targeted counseling can lead to adequate treatment with hearing…”
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Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization by Baganha, Fabiana, de Jong, Rob C. M., Peters, Erna A., Voorham, Wietske, Jukema, J. Wouter, Delibegovic, Mirela, de Vries, Margreet R., Quax, Paul H. A.

“…Objective Statins pleiotropically provide additional benefits in reducing atherosclerosis, but their effects on intraplaque angiogenesis (IPA) and hemorrhage…”
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Single Vocal Cord Irradiation: Image Guided Intensity Modulated Hypofractionated Radiation Therapy for T1a Glottic Cancer: Early Clinical Results by Al-Mamgani, Abrahim, MD, PhD, Kwa, Stefan L.S., PhD, Tans, Lisa, MD, Moring, Michael, RTT, Fransen, Dennie, RTT, Mehilal, Robert, MD, Verduijn, Gerda M., MD, Baatenburg de Jong, Rob J., MD, PhD, Heijmen, Ben J.M., PhD, Levendag, Peter C., MD, PhD

“…Purpose To report, from a retrospective analysis of prospectively collected data, on the feasibility, outcome, toxicity, and voice-handicap index (VHI) of…”
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Frailty in Non-geriatric Patients With Head and Neck cancer by Bakas, Ajay T, Polinder-Bos, Harmke A, Streng, Fleur, Mattace-Raso, Francesco U S, Ziere, Gijsbertus, de Jong, Rob J Baatenburg, Sewnaik, Aniel

“…Patients with head and neck cancer (HNC) are characterized by a poor lifestyle and comorbidity. The Geriatric 8 (G8) is an established screening tool to…”
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Phosphorylcholine Monoclonal Antibody Therapy Decreases Intraplaque Angiogenesis and Intraplaque Hemorrhage in Murine Vein Grafts by Baganha, Fabiana, Sluiter, Thijs J., de Jong, Rob C. M., van Alst, Louise A., Peters, Hendrika A. B., Jukema, J. Wouter, Delibegovic, Mirela, Pettersson, Knut, Quax, Paul H. A., de Vries, Margreet R.

“…Phosphorylcholine (PC) is one of the main oxLDL epitopes playing a central role in atherosclerosis, due to its atherogenic and proinflammatory effects. PC can…”
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Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis by Welten, Sabine M.J, de Jong, Rob C.M, Wezel, Anouk, de Vries, Margreet R, Boonstra, Martin C, Parma, Laura, Jukema, J. Wouter, van der Sluis, Tetje C, Arens, Ramon, Bot, Ilze, Agrawal, Sudhir, Quax, Paul H.A, Nossent, A. Yaël

“…Abstract Background and aims We aimed at investigating the role of 14q32 microRNAs in intimal hyperplasia and accelerated atherosclerosis; two major…”
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Study retention and attrition in a longitudinal cohort study including patient-reported outcomes, fieldwork and biobank samples: results of the Netherlands quality of life and Biomedical cohort study (NET-QUBIC) among 739 head and neck cancer patients and 262 informal caregivers by Jansen, Femke, Brakenhoff, Ruud H, Baatenburg de Jong, Rob J, Langendijk, Johannes A, Leemans, C René, Takes, Robert P, Terhaard, Chris H J, Smit, Jan H, Verdonck-de Leeuw, Irma M

“…Longitudinal observational cohort studies in cancer patients are important to move research and clinical practice forward. Continued study participation (study…”
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Complement Is Activated by IgG Hexamers Assembled at the Cell Surface by Diebolder, Christoph A., Beurskens, Frank J., de Jong, Rob N., Koning, Roman I., Strumane, Kristin, Lindorfer, Margaret A., Voorhorst, Marleen, Ugurlar, Deniz, Rosati, Sara, Heck, Albert J. R., van de Winkel, Jan G. J., Wilson, Ian A., Koster, Abraham J., Taylor, Ronald P., Saphire, Erica Ollmann, Burton, Dennis R., Schuurman, Janine, Gros, Piet, Parren, Paul W. H. I.

“…Complement activation by antibodies bound to pathogens, tumors, and self antigens is a critical feature of natural immune defense, a number of disease…”
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Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post‐ischaemic inflammatory response by Pluijmert, Niek J., Jong, Rob C. M., Vries, Margreet R., Pettersson, Knut, Atsma, Douwe E., Jukema, J. Wouter, Quax, Paul H. A.

“…Phosphorylcholine is a pro‐inflammatory epitope exposed on apoptotic cells, and phosphorylcholine monoclonal immunoglobulin (Ig)G antibodies (PC‐mAb) have…”
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A prospective evaluation of patient-reported quality-of-life after (chemo)radiation for oropharyngeal cancer: Which patients are at risk of significant quality-of-life deterioration? by Al-Mamgani, Abrahim, Rooij, Peter van, Tans, Lisa, Verduijn, Gerda M, Sewnaik, Aniel, Jong, Rob J. Baatenburg de

“…Abstract Background and purpose To prospectively investigate the impact of different patients’ characteristics on quality-of-life (QoL) after (chemo)radiation…”
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Unraveling the Macromolecular Pathways of IgG Oligomerization and Complement Activation on Antigenic Surfaces by Strasser, Jürgen, de Jong, Rob N, Beurskens, Frank J, Wang, Guanbo, Heck, Albert J. R, Schuurman, Janine, Parren, Paul W. H. I, Hinterdorfer, Peter, Preiner, Johannes

“…IgG antibodies play a central role in protection against pathogens by their ability to alert and activate the innate immune system. Here, we show that IgGs…”
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Prevalence of age‐related hearing loss, including sex differences, in older adults in a large cohort study by Homans, Nienke C., Metselaar, R. Mick, Dingemanse, J. Gertjan, van der Schroeff, Marc P., Brocaar, Michael P., Wieringa, Marjan H., Baatenburg de Jong, Rob J., Hofman, Albert, Goedegebure, André

“…Objectives/Hypothesis To obtain actual status of age‐related hearing loss in a general unscreened population of older Dutch adults and to investigate whether…”
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