Search Results - "de Jesus, Reynalda"

Selective small-molecule inhibition of an RNA structural element by Howe, John A., Wang, Hao, Fischmann, Thierry O., Balibar, Carl J., Xiao, Li, Galgoci, Andrew M., Malinverni, Juliana C., Mayhood, Todd, Villafania, Artjohn, Nahvi, Ali, Murgolo, Nicholas, Barbieri, Christopher M., Mann, Paul A., Carr, Donna, Xia, Ellen, Zuck, Paul, Riley, Dan, Painter, Ronald E., Walker, Scott S., Sherborne, Brad, de Jesus, Reynalda, Pan, Weidong, Plotkin, Michael A., Wu, Jin, Rindgen, Diane, Cummings, John, Garlisi, Charles G., Zhang, Rumin, Sheth, Payal R., Gill, Charles J., Tang, Haifeng, Roemer, Terry

“…Riboswitches are non-coding RNA structures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or ion, to regulate gene…”
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Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics by Tang, Haifeng, Walsh, Shawn P, Yan, Yan, de Jesus, Reynalda K, Shahripour, Aurash, Teumelsan, Nardos, Zhu, Yuping, Ha, Sookhee, Owens, Karen A, Thomas-Fowlkes, Brande S, Felix, John P, Liu, Jessica, Kohler, Martin, Priest, Birgit T, Bailey, Timothy, Brochu, Richard, Alonso-Galicia, Magdalena, Kaczorowski, Gregory J, Roy, Sophie, Yang, Lihu, Mills, Sander G, Garcia, Maria L, Pasternak, Alexander

“…The renal outer medullary potassium channel (ROMK or Kir1.1) is a putative drug target for a novel class of diuretics that could be used for the treatment of…”
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Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis by Garcia, Maria L, Priest, Birgit T, Alonso-Galicia, Magdalena, Zhou, Xiaoyan, Felix, John P, Brochu, Richard M, Bailey, Timothy, Thomas-Fowlkes, Brande, Liu, Jessica, Swensen, Andrew, Pai, Lee-Yuh, Xiao, Jianying, Hernandez, Melba, Hoagland, Kimberly, Owens, Karen, Tang, Haifeng, de Jesus, Reynalda K, Roy, Sophie, Kaczorowski, Gregory J, Pasternak, Alexander

“…The renal outer medullary potassium (ROMK) channel, which is located at the apical membrane of epithelial cells lining the thick ascending loop of Henle and…”
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Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold by Zhu, Yuping, de Jesus, Reynalda K., Tang, Haifeng, Walsh, Shawn P., Jiang, Jinlong, Gu, Xin, Teumelsan, Nardos, Shahripour, Aurash, Pio, Barbara, Ding, Fa-Xiang, Ha, Sookhee, Priest, Birgit T., Swensen, Andrew M., Alonso-Galicia, Magdalena, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Zhou, Xiaoyan, Pai, Lee-Yuh, Hampton, Caryn, Hernandez, Melba, Owens, Karen, Ehrhart, Juliann, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Parmee, Emma R., Sullivan, Kathleen, Garcia, Maria L., Pasternak, Alexander

“…[Display omitted] Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was…”
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Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation by Walsh, Shawn P., Shahripour, Aurash, Tang, Haifeng, de Jesus, Reynalda K., Teumelsan, Nardos, Zhu, Yuping, Frie, Jessica, Priest, Birgit T., Swensen, Andrew M., Alonso-Galicia, Magdalena, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Zhou, Xiaoyan, Pai, Lee-Yuh, Hampton, Caryn, Hernandez, Melba, Owens, Karen, Ehrhart, Juliann, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Garcia, Maria L., Pasternak, Alexander

“…[Display omitted] Following the discovery of small molecule acyl piperazine ROMK inhibitors and their initial preclinical validation as a novel diuretic agent,…”
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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities by Tang, Haifeng, Yan, Yan, Feng, Zhe, de Jesus, Reynalda K., Yang, Lihu, Levorse, Dorothy A., Owens, Karen A., Akiyama, Taro E., Bergeron, Raynald, Castriota, Gino A., Doebber, Thomas W., Ellsworth, Kenneth P., Lassman, Michael E., Li, Cai, Wu, Margaret S., Zhang, Bei B., Chapman, Kevin T., Mills, Sander G., Berger, Joel P., Pasternak, Alexander

“…A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs…”
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4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors and anticonvulsant activity by Hutchison, Alan J, Williams, Michael, Angst, Christoff, De Jesus, Reynalda, Blanchard, Louis, Jackson, Robert H, Wilusz, E. Jay, Murphy, Deborah E, Bernard, Patrick S

“…A series of 4-(phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids were synthesized, and their biological activity was assessed as…”
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Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates by Mandal, Mihirbaran, Xiao, Li, Pan, Weidong, Scapin, Giovanna, Li, Guoqing, Tang, Haiqun, Yang, Shu-Wei, Pan, Jianping, Root, Yuriko, de Jesus, Reynalda Keh, Yang, Christine, Prosise, Winnie, Dayananth, Priya, Mirza, Asra, Therien, Alex G., Young, Katherine, Flattery, Amy, Garlisi, Charles, Zhang, Rumin, Chu, Donald, Sheth, Payal, Chu, Inhou, Wu, Jin, Markgraf, Carrie, Kim, Hai-Young, Painter, Ronald, Mayhood, Todd W., DiNunzio, Edward, Wyss, Daniel F., Buevich, Alexei V., Fischmann, Thierry, Pasternak, Alexander, Dong, Shuzhi, Hicks, Jacqueline D., Villafania, Artjohn, Liang, Lianzhu, Murgolo, Nicholas, Black, Todd, Hagmann, William K., Tata, Jim, Parmee, Emma R., Weber, Ann E., Su, Jing, Tang, Haifeng

“…With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting…”
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Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst 3 Antagonist by Pasternak, Alexander, Feng, Zhe, de Jesus, Reynalda, Ye, Zhixiong, He, Shuwen, Dobbelaar, Peter, Bradley, Scott A., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Eiermann, George J., Li, Cai, Feng, Yue, Wu, Margaret, Shao, Qing, Zhang, Bei B., Nargund, Ravi, Mills, Sander G., Howard, Andrew D., Yang, Lihu, Zhou, Yun-Ping

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Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist by Pasternak, Alexander, Feng, Zhe, de Jesus, Reynalda, Ye, Zhixiong, He, Shuwen, Dobbelaar, Peter, Bradley, Scott A, Chicchi, Gary G, Tsao, Kwei-Lan, Trusca, Dorina, Eiermann, George J, Li, Cai, Feng, Yue, Wu, Margaret, Shao, Qing, Zhang, Bei B, Nargund, Ravi, Mills, Sander G, Howard, Andrew D, Yang, Lihu, Zhou, Yun-Ping

“…This letter provides the first pharmacological proof of principle that the sst3 receptor mediates glucose-stimulated insulin secretion (GSIS) from pancreatic…”
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Ortho-Substituted Benzofused Macrocyclic Lactams as Zinc Metalloprotease Inhibitors by Ksander, Gary M, de Jesus, Reynalda, Yuan, Andrew, Ghai, Trapani, A, McMartin, Colin, Bohacek, Regine

“…The design and preparation of ortho-substituted benzofused macrocyclic lactams are described. The benzofused macrocyclic lactams were designed as neutral…”
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2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands by Hutchison, Alan J, Williams, Michael, De Jesus, Reynalda, Yokoyama, Rina, Oei, Howard H, Ghai, Geetha R, Webb, Randy L, Zoganas, Harry C, Stone, George A, Jarvis, Michael F

“…The synthesis and receptor-binding profiles at adenosine receptor subtypes for a series of 2-(arylalkylamino)-adenosin-5'-uronamides is described. Halogenated…”
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2H-[1]Benzopyrano[3,4-b]pyridines. Synthesis and activity at central monoamine receptors by Hutchison, Alan, Williams, Michael, De Jesus, Reynalda, Stone, George A, Sylvester, L, Clarke, Frank H, Sills, Matthew A

“…Two general synthetic approaches to a novel series of 2H-[1]benzopyrano[3,4-b]pyridines are described together with their receptor binding profile at a variety…”
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Meta-Substituted Benzofused Macrocyclic Lactams as Zinc Metalloprotease Inhibitors by Ksander, Gary M, de Jesus, Reynalda, Yuan, Andrew, Ghai, Raj D, McMartin, Colin, Bohacek, Regine

“…The design, synthesis, and biochemical profile of meta-substituted benzofused macrocyclic lactams are described. The meta-substituted benzofused macrocyclic…”
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Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity by Hutchison, Alan J, De Jesus, Reynalda, Williams, Michael, Simke, John P, Neale, Robert F, Jackson, Robert H, Ambrose, Francis, Barbaz, Beverly J, Sills, Matthew A

“…A general synthetic approach to a novel series of cis-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols is described together with their receptor-binding…”
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A study of superoxide reactivity. Reaction of potassium superoxide with alkyl halides and tosylates by Chern, Chuen-Ing, DiCosimo, Robert, De Jesus, Reynalda, San Filippo, Joseph

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