Structural and Phylogenetic In Silico Characterization of Vitis vinifera PRR Protein as Potential Target for Plasmopara viticola Infection

Fungi infection, especially derived from , causes severe grapevine economic losses worldwide. Despite the availability of chemical treatments, looking for eco-friendly ways to control infection is gaining much more attention. When a plant is infected, multiple disease-control molecular mechanisms ar...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 25; no. 17; p. 9553
Main Authors:	Martínez-Navarro, Sofía M, de Iceta Soler, Xavier, Martínez-Martínez, Mónica, Olazábal-Morán, Manuel, Santos-Moriano, Paloma, Gómez, Sara
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 03-09-2024
Subjects:	Amino Acid Sequence Amino acids Bioinformatics By products Chromosomes Computer Simulation Disease downy mildew Fungicides Genes Genomes Genomics Host-Pathogen Interactions - genetics Infections Kinases lectin domain lectin receptor-like kinase (LecRLK) Lectins Molecular Docking Simulation Oomycetes Pathogens Pattern Recognition Receptors (PRRs) Pesticides Phylogenetics Phylogeny Plant Diseases - genetics Plant Diseases - microbiology Plant Proteins - chemistry Plant Proteins - genetics Plant Proteins - metabolism Plasmopara viticola Proteins Receptors, Pattern Recognition - chemistry Receptors, Pattern Recognition - genetics Receptors, Pattern Recognition - metabolism Signal transduction Vitis - genetics Vitis - metabolism Vitis - microbiology Vitis vinifera Pattern Recognition Receptors (PRRs) carbohydrate recognition downy mildew lectin domain Plasmopara viticola lectin receptor-like kinase (LecRLK) Vitis vinifera
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Summary:	Fungi infection, especially derived from , causes severe grapevine economic losses worldwide. Despite the availability of chemical treatments, looking for eco-friendly ways to control infection is gaining much more attention. When a plant is infected, multiple disease-control molecular mechanisms are activated. PRRs (Pattern Recognition Receptors) and particularly RLKs (receptor-like kinases) take part in the first barrier of the immune system, and, as a consequence, the kinase signaling cascade is activated, resulting in an immune response. In this context, discovering new lectin-RLK (LecRLK) membrane-bounded proteins has emerged as a promising strategy. The genome-wide localization of potential LecRLKs involved in disease defense was reported in two grapevine varieties of great economic impact: Chardonnay and Pinot Noir. A total of 23 potential amino acid sequences were identified, exhibiting high-sequence homology and evolution related to tandem events. Based on the domain architecture, a carbohydrate specificity ligand assay was conducted with docking, revealing two sequences as candidates for specific host-pathogen interaction. This study confers a starting point for designing new effective antifungal treatments directed at LecRLK targets in .
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms25179553