Search Results - "de Hoog, Leon"

Mice deficient in endothelial α5 integrin are profoundly resistant to experimental ischemic stroke by Roberts, Jill, de Hoog, Leon, Bix, Gregory J

“…Stroke is a disease in dire need of better therapies. We have previously shown that a fragment of the extracellular matrix proteoglycan, perlecan, has…”
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Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice by Trout, Amanda L., Kahle, Michael P., Roberts, Jill M., Marcelo, Aileen, de Hoog, Leon, Boychuk, Jeffery A., Grupke, Stephen L., Berretta, Antonio, Gowing, Emma K., Boychuk, Carie R., Gorman, Amanda A., Edwards, Danielle N., Rutkai, Ibolya, Biose, Ifechukwude J., Ishibashi-Ueda, Hatsue, Ihara, Masafumi, Smith, Bret N., Clarkson, Andrew N., Bix, Gregory J.

“…The extracellular matrix fragment perlecan domain V is neuroprotective and functionally restorative following experimental stroke. As neurogenesis is an…”
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Mice deficient in endothelial alpha 5 integrin are profoundly resistant to experimental ischemic stroke by Roberts, Jill, de Hoog, Leon, Bix, Gregory J

“…Stroke is a disease in dire need of better therapies. We have previously shown that a fragment of the extracellular matrix proteoglycan, perlecan, has…”
Get full text

Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome by Haley, Michael J, Krishnan, Siddharth, Burrows, David, de Hoog, Leon, Thakrar, Jamie, Schiessl, Ingo, Allan, Stuart M, Lawrence, Catherine B

“…Chronic consumption of diets high in fat leads to obesity and can negatively affect brain function. Rodents made obese by long-term maintenance on a high-fat…”
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Abstract 66: Endothelial α5β1 Integrin is Acutely Upregulated and Destabilizes the Blood-brain Barrier After Stroke by Edwards, Danielle, Roberts, Jill, de Hoog, Leon, Bix, Greg J

“…Abstract only Repeated opening of the blood-brain barrier (BBB) after ischemic stroke significantly contributes to brain injury. As the β1 integrin receptor…”
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Abstract W MP90: Suppression of Endothelial Cell Alpha5Beta1 Integrin Prevents Ischemic Stroke Injury in Mice by Roberts, Jill, de Hoog, Leon, Bix, Gregory J

“…Abstract only Although breakdown of the blood-brain barrier (BBB) leads to significant injury after ischemic stroke, therapies that target this breakdown have…”
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Abstract 163: Delayed Administration of Perlecan Doman V Significantly Increases Neurogenesis and Improves Functional Outcome after Experimental Ischemic Stroke by Marcelo-McCabe, Aileen, de Hoog, Leon, Clarkson, Andrew, Kahle, Michael, Bix, Gregory

“…Abstract only Stroke, a major cause of significant morbidity and death, has limited therapeutic options. To that end, our goal is to develop novel stroke…”
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