Soluble CD30, Acute Rejection, and Graft Survival: Pre- and 6-Month Post-Transplant Determinations—When Is the Best Time to Measure?

Pretransplantation soluble CD30 (sCD30) has been shown to be a good predictor of acute rejection (AR) and graft loss. This study aimed to evaluate the effectiveness of sCD30 measured pretransplant and up to 6 months after transplantation as a predictor of AR, graft loss, and survival at 5 years post...

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Bibliographic Details
Published in:	Transplantation proceedings Vol. 50; no. 3; pp. 728 - 736
Main Authors:	de Holanda, M.I., Matuck, T., de Carvalho, D.d.B.M., Domingues, E.M.F.L., Curvo, R., Glasberg, D.S., Santos, A.M.G., Borela, Á.M., Pôrto, L.C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-04-2018
Subjects:	Adult Biomarkers - blood Female Graft Rejection - blood Graft Survival - physiology Humans Ki-1 Antigen - blood Kidney Transplantation - adverse effects Male Middle Aged Postoperative Period Predictive Value of Tests Preoperative Period Time Factors
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Summary:	Pretransplantation soluble CD30 (sCD30) has been shown to be a good predictor of acute rejection (AR) and graft loss. This study aimed to evaluate the effectiveness of sCD30 measured pretransplant and up to 6 months after transplantation as a predictor of AR, graft loss, and survival at 5 years post-transplantation. Subjects were patients receiving living donor renal transplants at Bonsucesso Federal Hospital (Rio de Janeiro) in 2006 and between August 2010 and May 2011. sCD30 was analyzed in samples collected pretransplantation and 7, 14, and 21, 28 days and 3, 4, 5, and 6 months post-transplantation from 73 kidney recipients. Patients in the AR group did not present a positive correlation with the sCD30 levels pretransplant (P = .54); in the post-transplant period, the 7- to 14-day samples showed patients with AR had higher levels of this biomarker (P = .036). The graft survival in 5 years of follow-up was not different between groups. The best time to predict AR using sCD30 is the 7- to 14-day sample; however, identifying and following the decrease of this biomarker from pre- to post-transplant seems to be better than just 1 measurement. The sCD30 post-transplant is another tool that may be used in monitoring patients after renal transplantation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2018.02.025