Search Results - "de Heer, Iris"

Electroencephalographic Density Spectral Array monitoring in pediatric anesthesia: clinical background and practical applications by de Heer, Iris J, Weber, Frank

“…Depth of hypnosis monitoring using numerical index based processed electroencephalography is part of the standard anesthesia equipment in many operating rooms…”
Get full text

Transcriptome analysis reveals tumor microenvironment changes in glioblastoma by Hoogstrate, Youri, Draaisma, Kaspar, Ghisai, Santoesha A., van Hijfte, Levi, Barin, Nastaran, de Heer, Iris, Coppieters, Wouter, van den Bosch, Thierry P.P., Bolleboom, Anne, Gao, Zhenyu, Vincent, Arnaud J.P.E., Karim, Latifa, Deckers, Manon, Taphoorn, Martin J.B., Kerkhof, Melissa, Weyerbrock, Astrid, Sanson, Marc, Hoeben, Ann, Lukacova, Slávka, Lombardi, Giuseppe, Leenstra, Sieger, Hanse, Monique, Fleischeuer, Ruth E.M., Watts, Colin, Angelopoulos, Nicos, Gorlia, Thierry, Golfinopoulos, Vassilis, Bours, Vincent, van den Bent, Martin J., Robe, Pierre A., French, Pim J.

“…A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing…”
Get full text

Electroencephalographic density spectral array monitoring during propofol sedation in teenagers, using the narcotrend electroencephalographic monitor by de Heer, Iris J, Warmenhoven, Annejet T, Weber, Frank

“…Recently published articles address concerns about the safe use of currently available index-based depth of hypnosis monitors. Electroencephalographic Density…”
Get full text

Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations by Tesileanu, C. Mircea S., Vallentgoed, Wies R., Sanson, Marc, Taal, Walter, Clement, Paul M., Wick, Wolfgang, Brandes, Alba Ariela, Baurain, Jean Francais, Chinot, Olivier L., Wheeler, Helen, Gill, Sanjeev, Griffin, Matthew, Rogers, Leland, Rudà, Roberta, Weller, Michael, McBain, Catherine, Reijneveld, Jaap, Enting, Roelien H., Caparrotti, Francesca, Lesimple, Thierry, Clenton, Susan, Gijtenbeek, Anja, Lim, Elizabeth, de Vos, Filip, Mulholland, Paul J., Taphoorn, Martin J. B., de Heer, Iris, Hoogstrate, Youri, de Wit, Maurice, Boggiani, Lorenzo, Venneker, Sanne, Oosting, Jan, Bovée, Judith V. M. G., Erridge, Sara, Vogelbaum, Michael A., Nowak, Anna K., Mason, Warren P., Kros, Johan M., Wesseling, Pieter, Aldape, Ken, Jenkins, Robert B., Dubbink, Hendrikus J., Baumert, Brigitta, Golfinopoulos, Vassilis, Gorlia, Thierry, van den Bent, Martin, French, Pim J.

“…Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high frequency in several tumour types. Even though these mutations are confined…”
Get full text

Midlatency auditory evoked potentials during anesthesia in children: A narrative review by Cheung, Yuen M., Heer, Iris J., Stolker, Robert Jan, Weber, Frank, Kurth, Dean

“…The brain is considered as the major target organ of anesthetic agents. Despite that, a reliable means to monitor its function during anesthesia is lacking…”
Get full text

Electroencephalographic density spectral array monitoring during propofol/sevoflurane coadministration in children, an exploratory observational study by de Heer, Iris J., Raab, Hannah A.C., Krul, Stephan, Karaöz-Bulut, Gulhan, Stolker, Robert-Jan, Weber, Frank

“…Propofol and sevoflurane have a long history in pediatric anesthesia. Combining both drugs at low dose levels offers new opportunities. However, monitoring the…”
Get full text

Defining EGFR amplification status for clinical trial inclusion by French, Pim J, Eoli, Marica, Sepulveda, Juan Manuel, de Heer, Iris, Kros, Johan M, Walenkamp, Annemiek, Frenel, Jean-Sebastien, Franceschi, Enrico, Clement, Paul M, Weller, Michael, Ansell, Peter, Looman, Jim, Bain, Earle, Morfouace, Marie, Gorlia, Thierry, van den Bent, Martin

“…Precision medicine trials targeting the epidermal growth factor receptor (EGFR) in glioblastoma patients require selection for EGFR-amplified tumors. However,…”
Get full text

The predictive value of the Pleth Variability Index on fluid responsiveness in spontaneously breathing anaesthetized children—A prospective observational study by Weber, Frank, Rashmi, Bharat K., Karaoz‐Bulut, Gülhan, Dogger, Jaap, Heer, Iris J., Prasser, Christopher, Kurth, Dean

“…Background In children, the preoperative hydration status is an important part of the overall clinical assessment. The assumed preoperative fluid deficit is…”
Get full text

Mutation and drug-specific intracellular accumulation of EGFR predict clinical responses to tyrosine kinase inhibitors by de Wit, Maurice, Gao, Ya, Mercieca, Darlene, de Heer, Iris, Valkenburg, Bart, van Royen, Martin E., Aerts, Joachim, Sillevis Smitt, Peter, French, Pim

“…Clinical responses to EGFR tyrosine kinase inhibitors (TKIs) are restricted to tumors harboring specific activating mutations and even then, not all tyrosine…”
Get full text

Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study by van den Bent, Martin J, Tesileanu, C Mircea S, Wick, Wolfgang, Sanson, Marc, Brandes, Alba Ariela, Clement, Paul M, Erridge, Sarah, Vogelbaum, Michael A, Nowak, Anna K, Baurain, Jean Français, Mason, Warren P, Wheeler, Helen, Chinot, Olivier L, Gill, Sanjeev, Griffin, Matthew, Rogers, Leland, Taal, Walter, Rudà, Roberta, Weller, Michael, McBain, Catherine, Reijneveld, Jaap, Enting, Roelien H, Caparrotti, Francesca, Lesimple, Thierry, Clenton, Susan, Gijtenbeek, Anja, Lim, Elizabeth, Herrlinger, Ulrich, Hau, Peter, Dhermain, Frederic, de Heer, Iris, Aldape, Kenneth, Jenkins, Robert B, Dubbink, Hendrikus Jan, Kros, Johan M, Wesseling, Pieter, Nuyens, Sarah, Golfinopoulos, Vassilis, Gorlia, Thierry, French, Pim, Baumert, Brigitta G

“…The CATNON trial investigated the addition of concurrent, adjuvant, and both current and adjuvant temozolomide to radiotherapy in adults with newly diagnosed…”
Get full text

TMIC-39. PERIVASCULAR CONTAINMENT OF T CELLS IN IDH-MUTANT ASTROCYTOMA ASSOCIATES WITH HIGH ABUNDANCE OF GEMISTOCYTIC TUMOR CELLS AND IMMUNE STIMULATORY MICROGLIA by van Hijfte, Levi, Geurts, Marjolein, de Heer, Iris, Vallentgoed, Wies, Balcioglu, Emrah, Debets, Reno, French, Pim

“…Abstract Isocitrate dehydrogenase mutant (IDHmt) astrocytoma is considered a T cell-deficient tumor, yet little is known regarding the underlying mechanism…”
Get full text

3D‐Engineered Scaffolds to Study Microtubes and Localization of Epidermal Growth Factor Receptor in Patient‐Derived Glioma Cells by Barin, Nastaran, Balcioglu, Hayri E., de Heer, Iris, de Wit, Maurice, Lamfers, Martine L. M., van Royen, Martin E., French, Pim J., Accardo, Angelo

“…A major obstacle in glioma research is the lack of in vitro models that can retain cellular features of glioma cells in vivo. To overcome this limitation, a…”
Get full text

TMIC-37. GEMISTOCYTIC TUMOR CELLS AND IMMUNE REACTIVE MICROGLIA PROGRAMMED FOR GLIAL SCARRING CHARACTERIZE T CELL CONTAINMENT IN IDH-MUTANT ASTROCYTOMA by van Hijfte, Levi, Geurts, Marjolein, de Heer, Iris, Ghisai, Santoesha, Balcioglu, Hayri, Hoogstrate, Youri, Vallentgoed, Wies, Head, Rania, Westerman, Bart, Wesseling, Pieter, Joyce, Johanna, Debets, Reno, French, Pim

“…Abstract Isocitrate dehydrogenase 1/2 mutant (IDHmt) astrocytoma is considered a T cell-deprived tumor, yet little is known regarding the phenotype that…”
Get full text

3D‐Engineered Scaffolds to Study Microtubes and Localization of Epidermal Growth Factor Receptor in Patient‐Derived Glioma Cells (Small 49/2022) by Barin, Nastaran, Balcioglu, Hayri E., de Heer, Iris, de Wit, Maurice, Lamfers, Martine L. M., van Royen, Martin E., French, Pim J., Accardo, Angelo

“…3D Cell Culture In article number 2204485, Pim J. French, Angelo Accardo, and co‐workers develop a 3D‐engineered scaffold fabricated by two‐photon…”
Get full text

CSIG-24. LINEAR GRADING COEFFICIENT REVEALS EMBRYONIC DEVELOPMENT GENE SIGNATURE AS TREATMENT-INDEPENDENT PROGNOSTIC FACTOR IN IDH-MUTANT ASTROCYTOMA by Ghisai, Santoesha, Hoogstrate, Youri, Tesileanu, Mircea, van Hijfte, Levi, Vallentgoed, Wies, de Heer, Iris, Preusser, Matthias, Gorlia, Thierry, Sanson, Marc, van den Bent, Martin, French, Pim

“…Abstract BACKGROUND Since there is variation in prognosis within grade II/III and grade IV IDH-mutant astrocytomas, we sought to identify features that may aid…”
Get full text

Bevacizumab and temozolomide in patients with first recurrence of WHO grade II and III glioma, without 1p/19q co-deletion (TAVAREC): a randomised controlled phase 2 EORTC trial by van den Bent, Martin J, Klein, Martin, Smits, Marion, Reijneveld, Jaap C, French, Pim J, Clement, Paul, de Vos, Filip Y F, Wick, Antje, Mulholland, Paul J, Taphoorn, Martin J B, Lewis, Joanne, Weller, Michael, Chinot, Olivier L, Kros, Johan M, de Heer, Iris, Verschuere, Tina, Coens, Corneel, Golfinopoulos, Vassilis, Gorlia, Thierry, Idbaih, Ahmed

“…Bevacizumab is frequently used in the treatment of recurrent WHO grade II and III glioma, but without supporting evidence from randomised trials. Therefore, we…”
Get full text

Epigenetic landscape reorganisation and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma by Ghisai, Santoesha A., van Hijfte, Levi, Vallentgoed, Wies R., Tesileanu, C. Mircea S., de Heer, Iris, Kros, Johan M., Sanson, Marc, Gorlia, Thierry, Wick, Wolfgang, Vogelbaum, Michael A., Brandes, Alba A., Franceschi, Enrico, Clement, Paul M., Nowak, Anna K., Golfinopoulos, Vassilis, van den Bent, Martin J., French, Pim J., Hoogstrate, Youri

“…Accurate grading of IDH-mutant gliomas defines patient prognosis and guides the treatment path. Histological grading is challenging, and aside from CDKN2A/B…”
Get full text

CSIG-08. EXTRACELLULAR DOMAIN MUTATIONS IN EGFR RESULT IN A HYPERSENSITIVE RECEPTOR by French, Pim, de Wit, Maurice, de Heer, Iris, van Royen, Martin, Vallentgoed, Wies, Hoogstrate, youri, Sillevis Smitt, Peter

“…Abstract INTRODUCTION The Epidermal Growth Factor Receptor (EGFR) is a driver gene that is amplified in more than half of all glioblastomas. After the initial…”
Get full text

Abstract 2071: Protein aggregate formation predicts clinical responses to EGFR tyrosine kinase inhibitors by French, Pim, Gao, Ya, Wit, Maurice de, Mercieca, Darlene, Heer, Iris de, Valkenburg, Bart, Royen, Martin van, Aerts, Joachim, Smitt, Peter Sillevis

“…Abstract Although many tumours depend on EGFR signalling for growth, benefit from EGFR tyrosine kinase inhibitors (TKIs) is restricted to patients harboring…”
Get full text

DRES-14. PROTEIN AGGREGATE FORMATION PREDICTS CLINICAL RESPONSES TO EGFR TKIs by French, Pim, Gao, Ya, de Wit, Maurice, Mercieca, Darlene, de Heer, Iris, van Royen, Martin, Aerts, Joachim, Sillevis Smitt, Peter

“…Abstract BACKGROUND EGFR tyrosine kinase inhibitors (TKIs) have thus-far not shown clinical benefit for glioma patients, which is in stark contrast to the…”
Get full text