Search Results - "de Haas, Nienke"

STAT Family Protein Expression and Phosphorylation State during moDC Development Is Altered by Platinum-Based Chemotherapeutics by de Vries, I. Jolanda M., Flórez-Grau, Georgina, di Blasio, Stefania, de Koning, Coco, de Haas, Nienke, Hato, Stanleyson V.

“…The STAT signaling pathway is important in dendritic cell (DC) development and function. Tumor cells can induce STAT signaling, thereby inhibiting DC…”
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Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial by Boudewijns, Steve, Bloemendal, Martine, de Haas, Nienke, Westdorp, Harm, Bol, Kalijn F., Schreibelt, Gerty, Aarntzen, Erik H. J. G., Lesterhuis, W. Joost, Gorris, Mark A. J., Croockewit, Alexandra, van der Woude, Lieke L., van Rossum, Michelle M., Welzen, Marieke, de Goede, Anna, Hato, Stanleyson V., van der Graaf, Winette T. A., Punt, Cornelis J. A., Koornstra, Rutger H. T., Gerritsen, Winald R., Figdor, Carl G., de Vries, I. Jolanda M.

“…Background Autologous dendritic cell (DC) vaccines can induce tumor-specific T cells, but their effect can be counteracted by immunosuppressive mechanisms…”
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Improving cancer immunotherapy by targeting the STATe of MDSCs by de Haas, Nienke, de Koning, Coco, Spilgies, Lisanne, de Vries, I. Jolanda M., Hato, Stanleyson V.

“…Cancer immunotherapy is a promising therapeutic avenue; however, in practice its efficacy is hampered by an immunosuppressive tumor microenvironment that…”
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Cisplatin inhibits frequency and suppressive activity of monocytic myeloid-derived suppressor cells in cancer patients by Van Wigcheren, Glenn F., De Haas, Nienke, Mulder, Tom A., Horrevorts, Sophie K., Bloemendal, Martine, Hins-Debree, Simone, Mao, Yumeng, Kiessling, Rolf, van Herpen, Carla M.L., Flórez-Grau, Georgina, Hato, Stanleyson V., De Vries, I. Jolanda M.

“…Cancer immunotherapies have induced long-lasting responses in cancer patients including those with melanoma and head and neck squamous cell carcinoma (HNSCC)…”
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Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity by Hato, Stanleyson V, Figdor, Carl G, Takahashi, Susumu, Pen, Anja E, Halilovic, Altuna, Bol, Kalijn F, Vasaturo, Angela, Inoue, Yukie, de Haas, Nienke, Verweij, Dagmar, Van Herpen, Carla M L, Kaanders, Johannes H, van Krieken, Johan H J M, Van Laarhoven, Hanneke W M, Hooijer, Gerrit K J, Punt, Cornelis J A, Asai, Akira, de Vries, I Jolanda M, Lesterhuis, W Joost

“…Platinum-based chemotherapeutics are amongst the most powerful anti-cancer drugs. Although their exact mechanism of action is not well understood, it is…”
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Human CD1c+ DCs are critical cellular mediators of immune responses induced by immunogenic cell death by Di Blasio, Stefania, Wortel, Inge M. N., van Bladel, Diede A. G., de Vries, Laura E., Duiveman-de Boer, Tjitske, Worah, Kuntal, de Haas, Nienke, Buschow, Sonja I., de Vries, I. Jolanda M., Figdor, Carl G., Hato, Stanleyson V.

“…Chemotherapeutics, including the platinum compounds oxaliplatin (OXP) and cisplatin (CDDP), are standard care of treatment for cancer. Although chemotherapy…”
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Monitoring of dynamic changes in Keyhole Limpet Hemocyanin (KLH)-specific B cells in KLH-vaccinated cancer patients by Wimmers, Florian, de Haas, Nienke, Scholzen, Anja, Schreibelt, Gerty, Simonetti, Elles, Eleveld, Marc J., Brouwers, Huberdina M. L. M., Beldhuis-Valkis, Marjo, Joosten, Irma, de Jonge, Marien I., Gerritsen, Winald R., de Vries, I. Jolanda M., Diavatopoulos, Dimitri A., Jacobs, Joannes F. M.

“…Keyhole limpet hemocyanin (KLH) is used as an immunogenic neo-antigen for various clinical applications and during vaccine development. For advanced monitoring…”
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Preclinical exploration of combining plasmacytoid and myeloid dendritic cell vaccination with BRAF inhibition by Tel, Jurjen, Koornstra, Rutger, de Haas, Nienke, van Deutekom, Vincent, Westdorp, Harm, Boudewijns, Steve, van Erp, Nielka, Di Blasio, Stefania, Gerritsen, Winald, Figdor, Carl G, de Vries, I Jolanda M, Hato, Stanleyson V

“…Melanoma is the most lethal type of skin cancer and its incidence is progressively increasing. The introductions of immunotherapy and targeted therapies have…”
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