Soluble HLA-G Molecules Are Increased during Acute Leukemia, Especially in Subtypes Affecting Monocytic and Lymphoid Lineages

Human leukocyte antigen G (HLA-G) molecules corresponding to nonclassic class I genes of the major histocompatibility complex exhibit immunomodulatory properties. They are either membrane-bound or solubly expressed during certain tumoral malignancies. Soluble human leukocyte antigen G (sHLA-G) molec...

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Bibliographic Details
Published in:	Neoplasia (New York, N.Y.) Vol. 8; no. 3; pp. 223 - 230
Main Authors:	Gros, Frédéric, Sebti, Yasmine, de Guiber, Sophie, Branger, Bernard, Bernard, Marc, Fauchet, Renée, Amiot, Laurence
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-03-2006 Elsevier
Subjects:	acute lymphoblastic leukemia (ALL) acute myeloblastic leukemia (AML) Immunology immunomodulation Life Sciences myelodysplasia Soluble human leukocyte antigen G (sHLA-G) immunomodulation myelodysplasia Soluble human leukocyte antigen G (sHLA-G) acute lymphoblastic leukemia (ALL) acute myeloblastic leukemia (AML)
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Summary:	Human leukocyte antigen G (HLA-G) molecules corresponding to nonclassic class I genes of the major histocompatibility complex exhibit immunomodulatory properties. They are either membrane-bound or solubly expressed during certain tumoral malignancies. Soluble human leukocyte antigen G (sHLA-G) molecules seem more frequently expressed than membranebound isoforms during hematologic malignancies, such as lymphoproliferative disorders. Assay of these molecules by enzyme-linked immunosorbent assay in patients suffering from another hematologic disorder (acute leukemia) highlights increased sHLA-G secretion. This increased secretion seems more marked in acute leukemia subtypes affecting monocytic and lymphoid lineages such as FABM4 and FABM5, as well as both B and T acute lymphoblastic leukemia (ALL). Moreover, this study uses in vitro cytokine stimulations and reveals the respective potential roles of granulocyte-macrophage colony-stimulating factor and interferon-γ in increasing this secretion in FABM4 and ALL. Correlations between sHLA-G plasma level and clinical biologic features suggest a link between elevated sHLA-G level and 1) the absence of anterior myelodysplasia and 2) high-level leukocytosis. All these findings suggest that sHLA-G molecules could be a factor in tumoral escape from immune survey during acute leukemia.
ISSN:	1476-5586 1522-8002 1476-5586 1522-8002
DOI:	10.1593/neo.05703