Search Results - "de Groot, Nina E"

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts by van der Heijden, Maartje, Miedema, Daniël M., Waclaw, Bartlomiej, Veenstra, Veronique L., Lecca, Maria C., Nijman, Lisanne E., van Dijk, Erik, van Neerven, Sanne M., Lodestijn, Sophie C., Lenos, Kristiaan J., de Groot, Nina E., Prasetyanti, Pramudita R., Varea, Andrea Arricibita, Winton, Douglas J., Medema, Jan Paul, Morrissey, Edward, Ylstra, Bauke, Nowak, Martin A., Bijlsma, Maarten F., Vermeulen, Louis

“…Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics of malignant cells within tumors. However, the…”
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Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress by Sergeeva, Irina A, Hooijkaas, Ingeborg B, Ruijter, Jan M, van der Made, Ingeborg, de Groot, Nina E, van de Werken, Harmen J G, Creemers, Esther E, Christoffels, Vincent M

“…The paralogous genes Nppa and Nppb are organized in an evolutionarily conserved cluster and provide a valuable model for studying co-regulation and regulatory…”
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Intestinal Apc‐inactivation induces HSP25 dependency by van Neerven, Sanne M, Smit, Wouter L, van Driel, Milou S, Kakkar, Vaishali, de Groot, Nina E, Nijman, Lisanne E, Elbers, Clara C, Léveillé, Nicolas, Heijmans, Jarom, Vermeulen, Louis

“…The majority of colorectal cancers (CRCs) present with early mutations in tumor suppressor gene APC . APC mutations result in oncogenic activation of the Wnt…”
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Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development by Adam, Ronja S, van Neerven, Sanne M, Pleguezuelos-Manzano, Cayetano, Simmini, Salvatore, Léveillé, Nicolas, de Groot, Nina E, Holding, Andrew N, Markowetz, Florian, Vermeulen, Louis

“…Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance…”
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The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts by Komen, Job, van Neerven, Sanne M, Bossink, Elsbeth G B M, de Groot, Nina E, Nijman, Lisanne E, van den Berg, Albert, Vermeulen, Louis, van der Meer, Andries D

“…The cancer xenograft model in which human cancer cells are implanted in a mouse is one of the most used preclinical models to test the efficacy of novel cancer…”
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The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut by Ramadan, Rana, Wouters, Valérie M., van Neerven, Sanne M., de Groot, Nina E., Garcia, Tania Martins, Muncan, Vanessa, Franklin, Olivia D., Battle, Michelle, Carlson, Karen Sue, Leach, Joshua, Sansom, Owen J., Boulard, Olivier, Chamaillard, Mathias, Vermeulen, Louis, Medema, Jan Paul, Huels, David J.

“…The rapid renewal of the epithelial gut lining is fuelled by stem cells that reside at the base of intestinal crypts. The signal transduction pathways and…”
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Apc-mutant cells act as supercompetitors in intestinal tumour initiation by van Neerven, Sanne M., de Groot, Nina E., Nijman, Lisanne E., Scicluna, Brendon P., van Driel, Milou S., Lecca, Maria C., Warmerdam, Daniël O., Kakkar, Vaishali, Moreno, Leandro F., Vieira Braga, Felipe A., Sanches, Delano R., Ramesh, Prashanthi, ten Hoorn, Sanne, Aelvoet, Arthur S., van Boxel, Marouska F., Koens, Lianne, Krawczyk, Przemek M., Koster, Jan, Dekker, Evelien, Medema, Jan Paul, Winton, Douglas J., Bijlsma, Maarten F., Morrissey, Edward, Léveillé, Nicolas, Vermeulen, Louis

“…A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche is critical to maintaining the ISC compartment, as it…”
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The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice by van den Hoogenhof, Maarten M G, van der Made, Ingeborg, Beqqali, Abdelaziz, de Groot, Nina E, Damanafshan, Amin, van Oort, Ralph J, Pinto, Yigal M, Creemers, Esther E

“…The importance of tightly controlled alternative pre-mRNA splicing in the heart is emerging. The RNA binding protein Rbm24 has recently been identified as a…”
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The microRNA-15 family inhibits the TGFβ-pathway in the heart by Tijsen, Anke J, van der Made, Ingeborg, van den Hoogenhof, Maarten M, Wijnen, Wino J, van Deel, Elza D, de Groot, Nina E, Alekseev, Sergey, Fluiter, Kees, Schroen, Blanche, Goumans, Marie-José, van der Velden, Jolanda, Duncker, Dirk J, Pinto, Yigal M, Creemers, Esther E

“…The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis, which contributes to the development of heart failure. Signalling via the…”
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Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3′-End Formation in the Failing Human Heart by Creemers, Esther E, Bawazeer, Amira, Ugalde, Alejandro P, van Deutekom, Hanneke W.M, van der Made, Ingeborg, de Groot, Nina E, Adriaens, Michiel E, Cook, Stuart A, Bezzina, Connie R, Hubner, Norbert, van der Velden, Jolanda, Elkon, Ran, Agami, Reuven, Pinto, Yigal M

“…RATIONALE:Alternative cleavage and polyadenylation (APA) of mRNA represents a layer of gene regulation that to date has remained unexplored in the heart. This…”
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AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart by van den Hoogenhof, Maarten M. G., van der Made, Ingeborg, de Groot, Nina E., Damanafshan, Amin, van Amersfoorth, Shirley C. M., Zentilin, Lorena, Giacca, Mauro, Pinto, Yigal M., Creemers, Esther E.

“…The RNA-binding protein Rbm24 has recently been identified as a pivotal splicing factor in the developing heart. Loss of Rbm24 in mice disrupts cardiac…”
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Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition by van Driel, Milou S., Linssen, Jasmijn D.G., Flanagan, Dustin J., Vlahov, Nikola, Nijman, Lisanne E., de Groot, Nina E., Elbers, Clara C., Koster, Jan, Sansom, Owen J., Vermeulen, Louis, van Neerven, Sanne M.

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