Search Results - "de Groot, Martijn"

Phenylketonuria: reduced tyrosine brain influx relates to reduced cerebral protein synthesis by de Groot, Martijn J, Hoeksma, Marieke, Reijngoud, Dirk-Jan, de Valk, Harold W, Paans, Anne M J, Sauer, Pieter J J, van Spronsen, Francjan J

“…In phenylketonuria (PKU), elevated blood phenylalanine (Phe) concentrations are considered to impair transport of large neutral amino acids (LNAAs) from blood…”
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Single amino acid supplementation in aminoacidopathies: a systematic review by van Vliet, Danique, Derks, Terry G J, van Rijn, Margreet, de Groot, Martijn J, MacDonald, Anita, Heiner-Fokkema, M Rebecca, van Spronsen, Francjan J

“…Aminoacidopathies are a group of rare and diverse disorders, caused by the deficiency of an enzyme or transporter involved in amino acid metabolism. For most…”
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Phenylketonuria: Brain Phenylalanine Concentrations Relate Inversely to Cerebral Protein Synthesis by de Groot, Martijn J, Sijens, Paul E, Reijngoud, Dirk-Jan, Paans, Anne M, van Spronsen, Francjan J

“…In phenylketonuria, elevated plasma phenylalanine concentrations may disturb blood-to-brain large neutral amino acid (LNAA) transport and cerebral protein…”
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Large neutral amino acids in the treatment of PKU: from theory to practice by van Spronsen, Francjan J., de Groot, Martijn J., Hoeksma, Marieke, Reijngoud, Dirk-Jan, van Rijn, Margreet

“…Notwithstanding the success of the traditional dietary phenylalanine restriction treatment in phenylketonuria (PKU), the use of large neutral amino acid (LNAA)…”
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The Behavioral Consequence of Phenylketonuria in Mice Depends on the Genetic Background by Bruinenberg, Vibeke M, van der Goot, Els, van Vliet, Danique, de Groot, Martijn J, Mazzola, Priscila N, Heiner-Fokkema, M Rebecca, van Faassen, Martijn, van Spronsen, Francjan J, van der Zee, Eddy A

“…To unravel the role of gene mutations in the healthy and the diseased state, countless studies have tried to link genotype with phenotype. However, over the…”
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Key Components in eHealth Interventions Combining Self-Tracking and Persuasive eCoaching to Promote a Healthier Lifestyle: A Scoping Review by Lentferink, Aniek J, Oldenhuis, Hilbrand Ke, de Groot, Martijn, Polstra, Louis, Velthuijsen, Hugo, van Gemert-Pijnen, Julia Ewc

“…The combination of self-tracking and persuasive eCoaching in automated interventions is a new and promising approach for healthy lifestyle management. The aim…”
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De novo missense variants in HDAC3 leading to epigenetic machinery dysfunction are associated with a variable neurodevelopmental disorder by Yoon, Jihoon G, Lim, Seong-Kyun, Seo, Hoseok, Lee, Seungbok, Cho, Jaeso, Kim, Soo Yeon, Koh, Hyun Yong, Poduri, Annapurna H, Ramakumaran, Vijayalakshmi, Vasudevan, Pradeep, de Groot, Martijn J, Ko, Jung Min, Han, Dohyun, Chae, Jong-Hee, Lee, Chul-Hwan

“…Histone deacetylase 3 (HDAC3) is a crucial epigenetic modulator essential for various developmental and physiological functions. Although its dysfunction is…”
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A Conceptual Framework for Personal Science by Wolf, Gary Isaac, De Groot, Martijn

“…This paper introduces a conceptual framework to guide research and education into the practice of personal science, which we define as using empirical methods…”
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Single Subject (N-of-1) Research Design, Data Processing, and Personal Science by De Groot, Martijn, Drangsholt, Mark, Martin-Sanchez, Fernando J, Wolf, Gary

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Citizen Science for Health: An International Survey on Its Characteristics and Enabling Factors by Remmers, Gaston, Tzovaras, Bastian Greshake, Albert, Alexandra, Van Laer, Jef, Wildevuur, Sabine, De Groot, Martijn, den Broeder, Lea, Bonhoure, Isabelle, Magalhaes, Joana, Assens, Sara Mas, Torrents, Enric Garcia, Imre, Baris, Covernton, Eugenia

“…Even though citizen and patient engagement in health research has a long tradition, citizen science in health has only recently gained attention and…”
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Relationships between lumbar bone mineral density and biochemical parameters in phenylketonuria patients by de Groot, Martijn J., Hoeksma, Marieke, van Rijn, Margreet, Slart, Riemer H.J.A., van Spronsen, Francjan J.

“…The etiology of reduced bone mineral density (BMD) in phenylketonuria (PKU) is unknown. Reduced BMD may be inherent to PKU and/or secondary to its dietary…”
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Evaluation of DVH-based treatment plan verification in addition to gamma passing rates for head and neck IMRT by Visser, Ruurd, Wauben, David J.L, de Groot, Martijn, Steenbakkers, Roel J.H.M, Bijl, Henk P, Godart, Jeremy, van’t Veld, Aart A, Langendijk, Johannes A, Korevaar, Erik W

“…Abstract Background and purpose Treatment plan verification of intensity modulated radiotherapy (IMRT) is generally performed with the gamma index (GI)…”
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Causes of limited survival of microencapsulated pancreatic islet grafts by de Groot, Martijn, Schuurs, Theo A., van Schilfgaarde, Reinout

“…Successful transplantation of pancreatic tissue has been demonstrated to be an efficacious method of restoring glycemic control in type 1 diabetic patients. To…”
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Barriers to and Facilitators of Using a One Button Tracker and Web-Based Data Analytics Tool for Personal Science: Exploratory Study by van de Belt, Tom H, de Croon, Aimee, Freriks, Faye, Blomseth Christiansen, Thomas, Eg Larsen, Jakob, de Groot, Martijn

“…Individuals' self-tracking of subjectively experienced phenomena related to health can be challenging, as current options for instrumentation often involve too…”
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BH4 treatment in BH4-responsive PKU patients: preliminary data on blood prolactin concentrations suggest increased cerebral dopamine concentrations by van Vliet, Danique, Anjema, Karen, Jahja, Rianne, de Groot, Martijn J., Liemburg, Geertje B., Heiner-Fokkema, M. Rebecca, van der Zee, Eddy A., Derks, Terry G.J., Kema, Ido P., van Spronsen, Francjan J.

“…In phenylketonuria (PKU), cerebral neurotransmitter deficiencies have been suggested to contribute to brain dysfunction. Present treatment aims to reduce blood…”
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Metabolic investigations prevent liver transplantation in two young children with citrullinemia type I by de Groot, Martijn J., Cuppen, Marcel, Eling, Marc, Verheijen, Frans W., Rings, Edmond H. H. M., Reijngoud, Dirk-Jan, de Vries, Maaike M. C., van Spronsen, Francjan J.

“…Acute liver failure may be caused by a variety of disorders including inborn errors of metabolism. In those cases, rapid metabolic investigations and adequate…”
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Reliability and Validity of Ten Consumer Activity Trackers Depend on Walking Speed by FOKKEMA, TRYNTSJE, KOOIMAN, THEA J M, KRIJNEN, WIM P, VAN DER SCHANS, CEES P, DE GROOT, MARTIJN

“…PURPOSETo examine the test–retest reliability and validity of ten activity trackers for step counting at three different walking speeds. METHODSThirty-one…”
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Deterioration of Endothelial and Smooth Muscle Cell Function in DCD Kidneys After Static Cold Storage in IGL-1 or UW by Maathuis, Mark-Hugo J., M.D, de Groot, Martijn, Ph.D, Ploeg, Rutger J., M.D., Ph.D, Leuvenink, Henri G.D., Ph.D

“…Background Kidneys obtained from donors after cardiac death are damaged by the combination of warm and cold ischemia. Although the parenchymal damage of these…”
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Determinants for Sustained Use of an Activity Tracker: Observational Study by Hermsen, Sander, Moons, Jonas, Kerkhof, Peter, Wiekens, Carina, De Groot, Martijn

“…A lack of physical activity is considered to cause 6% of deaths globally. Feedback from wearables such as activity trackers has the potential to encourage…”
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Do activity monitors increase physical activity in adults with overweight or obesity? A systematic review and meta‐analysis by de Vries, Herman J., Kooiman, Thea J.M., van Ittersum, Miriam W., van Brussel, Marco, de Groot, Martijn

“…Objective To systematically assess contemporary knowledge regarding behavioral physical activity interventions including an activity monitor (BPAI+) in adults…”
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