Search Results - "de Groot, Daniël"

Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine by Spanjaard, Aldo, Shah, Ronak, de Groot, Daniël, Buoninfante, Olimpia Alessandra, Morris, Ben, Lieftink, Cor, Pritchard, Colin, Zürcher, Lisa M, Ormel, Shirley, Catsman, Joyce J I, de Korte-Grimmerink, Renske, Siteur, Bjørn, Proost, Natalie, Boadum, Terry, van de Ven, Marieke, Song, Ji-Ying, Kreft, Maaike, van den Berk, Paul C M, Beijersbergen, Roderick L, Jacobs, Heinz

“…Abstract Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion…”
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Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation by Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C M, Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J I, Pardieck, Iris N, Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E J, Jacobs, Heinz

“…The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene ( ) repertoires…”
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ADARp150 counteracts whole genome duplication by van Gemert, Frank, Drakaki, Alexandra, Lozano, Isabel Morales, de Groot, Daniël, Uiterkamp, Maud Schoot, Proost, Natalie, Lieftink, Cor, van de Ven, Marieke, Beijersbergen, Roderick L, Jacobs, Heinz, Te Riele, Hein

“…Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA…”
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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors by Lei, Xin, de Groot, Daniël C., Welters, Marij J. P., de Wit, Tom, Schrama, Ellen, van Eenennaam, Hans, Santegoets, Saskia J., Oosenbrug, Timo, van der Veen, Annemarthe, Vos, Joris L., Zuur, Charlotte L., de Miranda, Noel F. C. C., Jacobs, Heinz, van der Burg, Sjoerd H., Borst, Jannie, Xiao, Yanling

“…CD4 + T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8 + cytotoxic T lymphocyte (CTL) anticancer responses, as proven…”
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Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis by Xiao, Yanling, Zijl, Sebastiaan, Wang, Liqin, de Groot, Daniel C., van Tol, Maarten J., Lankester, Arjan C., Borst, Jannie

“…Osteoclasts (OCs) originate from the myeloid cell lineage, but the successive steps in their lineage commitment are ill-defined, especially in humans. To…”
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Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model by de Groot, Daniel, Spanjaard, Aldo, Hogenbirk, Marc A, Jacobs, Heinz

“…Chromothripsis defines a genetic phenomenon where up to hundreds of clustered chromosomal rearrangements can arise in a single catastrophic event. The…”
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Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma by Ramirez, Christel F. A., Taranto, Daniel, Ando-Kuri, Masami, de Groot, Marnix H. P., Tsouri, Efi, Huang, Zhijie, de Groot, Daniel, Kluin, Roelof J. C., Kloosterman, Daan J., Verheij, Joanne, Xu, Jing, Vegna, Serena, Akkari, Leila

“…Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been assigned…”
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Mammalian life depends on two distinct pathways of DNA damage tolerance by Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E J, Vivié, Judith, Mcgrath, Kathleen E, Huijbers, Ivo J, Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L, Palis, James, van den Berk, Paul C M, Jacobs, Heinz

“…DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance…”
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Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair by Shah, Ronak, Aslam, Muhammad Assad, Spanjaard, Aldo, de Groot, Daniel, Zürcher, Lisa M, Altelaar, Maarten, Hoekman, Liesbeth, Pritchard, Colin E J, Pilzecker, Bas, van den Berk, Paul C M, Jacobs, Heinz

“…The Fanconi anemia (FA) repair pathway governs repair of highly genotoxic DNA interstrand crosslinks (ICLs) and relies on translesion synthesis (TLS). TLS is…”
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Explorer Chemistry: Inside the Atom by De Groot, Daniel

“…De Groot reviews Explorer Chemistry: Inside the Atom from Logal Software…”
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Flatography: Detection of gastrointestinal diseases by faecal gas analysis by de Groot, Evelien F, de Meij, Tim G, Berkhout, Daniel J, van der Schee, Marc P, de Boer, Nanne K

“…Patients presenting with gastro-intestinal symptoms might suffer from a range of possible underlying diseases. An unmet need exists for novel…”
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Black and Nixon by Rosencwaig, Norman, De Groot, Daniel, Murray, Peter J

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