Search Results - "de Graaff, Marieke A"

Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity by de Graaff, Marieke A., MD, Cleton-Jansen, Anne-Marie, PhD, Szuhai, Károly, MD, PhD, Bovée, Judith V.M.G., MD, PhD

“…Summary Recently, heterozygous mutations in exon 2 of the mediator complex subunit 12 gene have been described in 50% to 70% of uterine leiomyomas; the…”
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Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging by Heijs, Bram, Holst-Bernal, Stephanie, de Graaff, Marieke A., Briaire-de Bruijn, Inge H., Rodriguez-Girondo, Mar, van de Sande, Michiel A.J., Wuhrer, Manfred, McDonnell, Liam A., Bovée, Judith V.M.G.

“…Myxoid liposarcoma (MLS) is the second most common subtype of liposarcoma, accounting for ~6% of all sarcomas. MLS is characterized by a pathognomonic…”
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High-Throughput Screening of Myxoid Liposarcoma Cell Lines: Survivin Is Essential for Tumor Growth by de Graaff, Marieke A., Malu, Shruti, Guardiola, Irma, Kruisselbrink, Alwine B., de Jong, Yvonne, Corver, Willem E., Gelderblom, H., Hwu, Patrick, Nielsen, Torsten O., Lazar, Alexander J., Somaiah, Neeta, Bovée, Judith V.M.G.

“…Myxoid liposarcoma (MLS) is a soft tissue sarcoma characterized by a recurrent t(12;16) translocation. Although tumors are initially radio- and chemosensitive,…”
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NY-ESO-1 (CTAG1B) expression in mesenchymal tumors by Endo, Makoto, de Graaff, Marieke A, Ingram, Davis R, Lim, Simin, Lev, Dina C, Briaire-de Bruijn, Inge H, Somaiah, Neeta, Bovée, Judith VMG, Lazar, Alexander J, Nielsen, Torsten O

“…New York esophageal squamous cell carcinoma 1 (NY-ESO-1, CTAG1B) is a cancer-testis antigen and currently a focus of several targeted immunotherapeutic…”
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Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors by Hoekstra, Attje S, de Graaff, Marieke A, Briaire-de Bruijn, Inge H, Ras, Cor, Seifar, Reza Maleki, van Minderhout, Ivonne, Cornelisse, Cees J, Hogendoorn, Pancras C W, Breuning, Martijn H, Suijker, Johnny, Korpershoek, Esther, Kunst, Henricus P M, Frizzell, Norma, Devilee, Peter, Bayley, Jean-Pierre, Bovée, Judith V M G

“…Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes and tumor suppressors. Loss-of-function mutations give…”
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High-grade sarcoma diagnosis and prognosis: Biomarker discovery by mass spectrometry imaging by Lou, Sha, Balluff, Benjamin, de Graaff, Marieke A., Cleven, Arjen H.G., Briaire - de Bruijn, Inge, Bovée, Judith V.M.G., McDonnell, Liam A.

“…The combination of high heterogeneity, both intratumoral and intertumoral, with their rarity has made diagnosis, prognosis of high‐grade sarcomas difficult…”
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Inhibition of Bcl-2 family members sensitises soft tissue leiomyosarcomas to chemotherapy by de Graaff, Marieke A, de Rooij, Marije A J, van den Akker, Brendy E W M, Gelderblom, Hans, Chibon, Fréderic, Coindre, Jean-Michel, Marino-Enriquez, Adrian, Fletcher, Jonathan A, Cleton-Jansen, Anne-Marie, Bovée, Judith V M G

“…Background: Leiomyosarcoma is an aggressive soft tissue sarcoma with a 5-year survival rate of 15 to 60%. Treatment options for inoperable or metastatic…”
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Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation by de Graaff, Marieke A, Yu, Jamie S E, Beird, Hannah C, Ingram, Davis R, Nguyen, Theresa, Juehui Liu, Jeffrey, Bolshakov, Svetlana, Szuhai, Károly, Åman, Pierre, Torres, Keila E, Lev, Dina, Nielsen, Torsten O, Bovée, Judith V M G, Lazar, Alexander J, Somaiah, Neeta

“…Myxoid liposarcoma has the pathognomonic fusion oncogene FUS-DDIT3 encoding a chimeric transcription factor. Metastatic risk is higher with an increased round…”
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A translocation t(6;14) in two cases of leiomyosarcoma: Molecular cytogenetic and array-based comparative genomic hybridization characterization by de Graaff, Marieke A, de Jong, Daniëlle, Briaire-de Bruijn, Inge H, Hogendoorn, Pancras C.W, Bovée, Judith V.M.G, Szuhai, Károly

“…Leiomyosarcomas are malignant mesenchymal tumors that recapitulate smooth muscle cell differentiation. Tumors are characterized by a genetic heterogeneity with…”
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High-Throughput Screening of Myxoid Liposarcoma Cell Lines: Survivin Is Essential for Tumor Growth12 by de Graaff, Marieke A., Malu, Shruti, Guardiola, Irma, Kruisselbrink, Alwine B., de Jong, Yvonne, Corver, Willem E., Gelderblom, H., Hwu, Patrick, Nielsen, Torsten O., Lazar, Alexander J., Somaiah, Neeta, Bovée, Judith V.M.G.

“…Myxoid liposarcoma (MLS) is a soft tissue sarcoma characterized by a recurrent t(12;16) translocation. Although tumors are initially radio- and chemosensitive,…”
Get full text