Search Results - "de Graaf, David"

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury by Xu, Jinghai J., Henstock, Peter V., Dunn, Margaret C., Smith, Arthur R., Chabot, Jeffrey R., de Graaf, David

“…Drug-induced liver injury (DILI) is the most common adverse event causing drug nonapprovals and drug withdrawals. Using drugs as test agents and measuring a…”
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Identification of Endoglin as a Functional Marker That Defines Long-Term Repopulating Hematopoietic Stem Cells by Chen, Chang-Zheng, Li, Min, de Graaf, David, Monti, Stefano, Göttgens, Berthold, Sanchez, Maria-Jose, Lander, Eric S., Golub, Todd R., Green, Anthony R., Lodish, Harvey F.

“…We describe a strategy to obtain highly enriched long-term repopulating (LTR) hematopoietic stem cells (HSCs) from bone marrow side-population (SP) cells by…”
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A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network by Amoutzias, Gregory D, Pichler, Elgar E, Mian, Nina, De Graaf, David, Imsiridou, Anastasia, Robinson-Rechavi, Marc, Bornberg-Bauer, Erich, Robertson, David L, Oliver, Stephen G

“…The nuclear receptors are a large family of eukaryotic transcription factors that constitute major pharmacological targets. They exert their combinatorial…”
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Involvement of MDR1 P‐glycoprotein in multifactorial resistance to methotrexate by Norris, Murray D., Graaf, David De, Haber, Michelle, Kavallaris, Maria, Madafiglio, Janice, Gilbert, Jayne, Kwan, Edward, Stewart, Bernard W., Mechetner, Eugene B., Gudkov, Andrei V., Roninson, Igor B.

“…Cellular resistance to methotrexate (MTX) is believed to be unaffected by expression of MDRI P‐glycoprotein (Pgp), a pleiotropic efflux pump acting on…”
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A decade of Systems Biology: where are we and where are we going to? by Peitsch, Manuel C., de Graaf, David

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A network-based approach to quantifying the impact of biologically active substances by Hoeng, Julia, Deehan, Renée, Pratt, Dexter, Martin, Florian, Sewer, Alain, Thomson, Ty M., Drubin, David A., Waters, Christina A., de Graaf, David, Peitsch, Manuel C.

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Systems diagnostics: anticipating the next generation of diagnostic tests based on mechanistic insight into disease by Fryburg, David A., Song, Diane H., Laifenfeld, Daphna, de Graaf, David

“…•Diagnoses often based on phenotypic presentation, not on mechanisms driving disease.•Treatments have become highly selective, molecularly focused.•Mismatch…”
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Verification of systems biology research in the age of collaborative competition by Meyer, Pablo, Alexopoulos, Leonidas G, Bonk, Thomas, Califano, Andrea, Cho, Carolyn R, de la Fuente, Alberto, de Graaf, David, Hartemink, Alexander J, Hoeng, Julia, Ivanov, Nikolai V, Koeppl, Heinz, Linding, Rune, Marbach, Daniel, Norel, Raquel, Peitsch, Manuel C, Rice, J Jeremy, Royyuru, Ajay, Schacherer, Frank, Sprengel, Joerg, Stolle, Katrin, Vitkup, Dennis, Stolovitzky, Gustavo

“…Collaborative competitions in which communities of researchers compete to solve challenges may facilitate more rigorous scrutiny of scientific results…”
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Applying computational modeling to drug discovery and development by Kumar, Neil, Hendriks, Bart S., Janes, Kevin A., de Graaf, David, Lauffenburger, Douglas A.

“…Computational models of cells, tissues and organisms are necessary for increased understanding of biological systems. In particular, modeling approaches will…”
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Blood-based identification of non-responders to anti-TNF therapy in rheumatoid arthritis by Thomson, Ty M, Lescarbeau, Reynald M, Drubin, David A, Laifenfeld, Daphna, de Graaf, David, Fryburg, David A, Littman, Bruce, Deehan, Renée, Van Hooser, Aaron

“…Faced with an increasing number of choices for biologic therapies, rheumatologists have a critical need for better tools to inform rheumatoid arthritis (RA)…”
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Multiple effects of acetaminophen and p38 inhibitors: Towards pathway toxicology by Xu, Jinghai J., Hendriks, Bart S., Zhao, Jie, de Graaf, David

“…The majority of drug-related toxicities are idiosyncratic, with little pathophysiological insight and mechanistic understanding. Pathway toxicology is an…”
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568 Therapeutic Diagnostic: Identification of Molecular Mechanisms Underlying Ulcerative Colitis in Infliximab Non-Responders at Baseline by Macoritto, Michael, Thomson, Ty, Park, Jennifer S, Drubin, David, Deehan-Kenney, Renee, De Graaf, David, Laifenfeld, Daphna

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Abstract 703: Verification of a novel approach to identify disease mechanisms in breast cancer patient subsets and application of this approach to indicating and characterizing tamoxifen resistance by Drubin, David A., Thomson, Ty M., Park, Jennifer S., Macoritto, Michael, de Graaf, David, Kenney, Renee D.

“…Abstract Breast cancer is a heterogeneous disease that can be divided into distinct clinical and molecular subtypes. Key biomarkers such as the expression of…”
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Early patient stratification and predictive biomarkers in drug discovery and development: a case study of ulcerative colitis anti-TNF therapy by Laifenfeld, Daphna, Drubin, David A, Catlett, Natalie L, Park, Jennifer S, Van Hooser, Aaron A, Frushour, Brian P, de Graaf, David, Fryburg, David A, Deehan, Renée

“…The current drug discovery paradigm is long, costly, and prone to failure. For projects in early development, lack of efficacy in Phase II is a major…”
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Verification of systems biology research in the age of collaborative competition: collaborative competitions in which communities of researchers compete to solve challenges may facilitate more rigorous scrutiny of scientific results by Meyer, Pablo, Alexopoulos, Leonidas G, Bonk, Thomas, Califano, Andrea, Cho, Carolyn R, de la Fuente, Alberto, de Graaf, David, Hartemink, Alexander J, Hoeng, Julia, Ivanov, Nikolai V, Koeppl, Heinz, Linding, Rune, Marbach, Daniel, Norel, Raquel, Peitsch, Manuel C, Rice, J. Jeremy, Royyuru, Ajay, Schacherer, Frank, Sprengel, Joerg, Stolle, Katrin, Vitkup, Dennis, Stolovitzky, Gustavo

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Involvement ofMDR1 P-glycoprotein in multifactorial resistance to methotrexate by Norris, Murray D., Graaf, David De, Haber, Michelle, Kavallaris, Maria, Madafiglio, Janice, Gilbert, Jayne, Kwan, Edward, Stewart, Bernard W., Mechetner, Eugene B., Gudkov, Andrei V., Roninson, Igor B.

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Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line by Espelin, Christopher W, Goldsipe, Arthur, Sorger, Peter K, Lauffenburger, Douglas A, de Graaf, David, Hendriks, Bart S

“…Rheumatoid arthritis (RA) is a complex, multicellular disease involving a delicate balance between both pro- and anti-inflammatory cytokines which ultimately…”
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P-Glycoprotein Confers Methotrexate Resistance in 3T6 Cells with Deficient Carrier-Mediated Methotrexate Uptake by De Graaf, David, Sharma, Rakesh C., Mechetner, Eugene B., Schimke, Robert T., Roninson, Igor B.

“…P-glycoprotein (Pgp), a transmembrane efflux pump encoded by the MDR1 gene, transports various lipophilic drugs that enter the cell by passive diffusion…”
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Chapter 25 Systems Biology and Kinase Signaling by Gomes, Bruce, de Graaf, David

“…Systems Biology enables a better understanding of the complexity of cell signaling pathways and offers potential insight into targets for disease intervention…”
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Isolation of altered-function mutants and genetic suppressor elements of multidrug transporter P-glycoprotein by expression selection from retroviral libraries by Roninson, I B, Zuhn, D, Ruth, A, de Graaf, D

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