Search Results - "de Grève, Jacques"

Performance of Two Geriatric Screening Tools in Older Patients With Cancer by KENIS, Cindy, DECOSTER, Lore, VAN PUYVELDE, Katrien, DE GREVE, Jacques, CONINGS, Godelieve, MILISEN, Koen, FLAMAING, Johan, LOBELLE, Jean-Pierre, WILDIERS, Hans

“…To compare the diagnostic characteristics of two geriatric screening tools (G8 and Flemish version of the Triage Risk Screening Tool [fTRST]) to identify…”
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miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells by Chen, Gang, Umelo, Ijeoma Adaku, Lv, Shasha, Teugels, Erik, Fostier, Karel, Kronenberger, Peter, Dewaele, Alex, Sadones, Jan, Geers, Caroline, De Grève, Jacques

“…Aberrant expression of microRNA-146a (miR-146a) has been reported to be involved in the development and progression of various types of cancers. However, its…”
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Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib by Noeparast, Amir, Teugels, Erik, Giron, Philippe, Verschelden, Gil, De Brakeleer, Sylvia, Decoster, Lore, De Grève, Jacques

“…Approximately half of BRAF-mutated Non-small cell lung cancers (NSCLCs) harbor a non-V600 BRAF mutation, accounting for ∼40,000 annual deaths worldwide. Recent…”
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Targeting USP13‐mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non‐small cell lung cancer by Giron, Philippe, Eggermont, Carolien, Noeparast, Amir, Vandenplas, Hugo, Teugels, Erik, Forsyth, Ramses, De Wever, Olivier, Aza‐Blanc, Pedro, Gutierrez, Gustavo J., De Grève, Jacques

“…In non‐small cell lung cancer (NSCLC), activating mutations in the epidermal growth factor receptor (EGFR) induce sensitivity to EGFR tyrosine kinase…”
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Therapeutic potential of the vagus nerve in cancer by Reijmen, Eva, Vannucci, Luca, De Couck, Marijke, De Grève, Jacques, Gidron, Yori

“…•Accumulating evidence points at a protective role of the vagus nerve in cancer pathologies.•The vagus nerve modulates innate and adaptive immune…”
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Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers by Joris, Sofie, Giron, Philippe, Olsen, Catharina, Seneca, Sara, Gheldof, Alexander, Staessens, Shula, Shahi, Rajendra Bahadur, De Brakeleer, Sylvia, Teugels, Erik, De Grève, Jacques, Hes, Frederik J

“…Among the 10% of pancreatic cancers that occur in a familial context, around a third carry a pathogenic variant in a cancer predisposition gene. Genetic…”
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Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab by Chen, Gang, Kronenberger, Peter, Teugels, Erik, Umelo, Ijeoma Adaku, De Grève, Jacques

“…The epidermal growth factor receptor (EGFR) is a validated therapeutic target in non-small cell lung cancer (NSCLC). However, current single agent receptor…”
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Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families by Shahi, Rajendra Bahadur, De Brakeleer, Sylvia, Caljon, Ben, Pauwels, Ingrid, Bonduelle, Maryse, Joris, Sofie, Fontaine, Christel, Vanhoeij, Marian, Van Dooren, Sonia, Teugels, Erik, De Grève, Jacques

“…In the majority of familial breast cancer (BC) families, the etiology of the disease remains unresolved. To identify missing BC heritability resulting from…”
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The EGFR-STYK1-FGF1 axis sustains functional drug tolerance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer by Eggermont, Carolien, Giron, Philippe, Noeparast, Maxim, Vandenplas, Hugo, Aza-Blanc, Pedro, Gutierrez, Gustavo J., De Grève, Jacques

“…Non-small cell lung cancer (NSCLC) patients harboring activating mutations in epidermal growth factor receptor (EGFR) are sensitive to therapy with EGFR…”
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Structure-Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors by Elsocht, Mathias, Giron, Philippe, Maes, Laila, Versées, Wim, Gutierrez, Gustavo J, De Grève, Jacques, Ballet, Steven

“…Lung cancer is one of the most frequently diagnosed cancers accounting for the highest number of cancer-related deaths in the world. Despite significant…”
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Synergistic effect of afatinib with su11274 in non-small cell lung cancer cells resistant to gefitinib or erlotinib by Chen, Gang, Noor, Alfiah, Kronenberger, Peter, Teugels, Erik, Umelo, Ijeoma Adaku, De Grève, Jacques

“…Epidermal growth factor receptor (EGFR) and c-MET receptors are expressed on many non-small cell lung cancer (NSCLC) cells. Current single agent therapeutic…”
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Combined inhibition of rho-associated protein kinase and EGFR suppresses the invasive phenotype in EGFR-dependent lung cancer cells by Umelo, Ijeoma Adaku, De Wever, Olivier, Kronenberger, Peter, Noor, Alfiah, Teugels, Erik, Chen, Gang, Bracke, Marc, De Grève, Jacques

“…Highlights • EGFR genomic status positively correlates with invasive capacity. • ROCK contributes to invasive capacity. • MYPT1, a ROCK effector, is a direct…”
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Transcutaneous Vagal Nerve Stimulation Alone or in Combination With Radiotherapy Stimulates Lung Tumor Infiltrating Lymphocytes But Fails to Suppress Tumor Growth by Reijmen, Eva, De Mey, Sven, Van Damme, Helena, De Ridder, Kirsten, Gevaert, Thierry, De Blay, Emmy, Bouwens, Luc, Collen, Christine, Decoster, Lore, De Couck, Marijke, Laoui, Damya, De Grève, Jacques, De Ridder, Mark, Gidron, Yori, Goyvaerts, Cleo

“…The combination of radiotherapy (RT) with immunotherapy represents a promising treatment modality for non-small cell lung cancer (NSCLC) patients. As only a…”
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Addressing disparities and challenges in underserved patient populations with metastatic breast cancer in Europe by Vrdoljak, Eduard, Gligorov, Joseph, Wierinck, Lieve, Conte, PierFranco, De Grève, Jacques, Meunier, Françoise, Palmieri, Carlo, Travado, Luzia, Walker, Andrew, Wiseman, Theresa, Wuerstlein, Rachel, Alba, Emilio, Biurrún, Concepción, D’Antona, Rosanna, Sola-Morales, Oriol, Ubaysi, Catherine, Ventura, Roberta, Cardoso, Fatima

“…People with metastatic breast cancer face many challenges and disparities in obtaining optimal cancer care. These challenges are accentuated in underserved…”
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Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2) by van der Noll, Ruud, Jager, Agnes, Ang, Joo Ern, Marchetti, Serena, Mergui-Roelvink, Marja W. J., de Bono, Johann S., Lolkema, Martijn P., de Jonge, Maja J. A., van der Biessen, Diane A., Brunetto, Andre T., Arkenau, Hendrik-Tobias, Tchakov, Ilian, Beijnen, Jos H., De Grève, Jacques, Schellens, Jan H. M.

“…Summary Background In the first part of this extensive phase I study (NCT00516724), continuous olaparib twice daily (bid) with carboplatin and/or paclitaxel…”
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Choroidal and Choriocapillaris Morphology in Pan-FGFR Inhibitor-Associated Retinopathy: A Case Report by Fasolino, Giuseppe, Moschetta, Laura, De Grève, Jacques, Nelis, Pieter, Lefesvre, Pierre, Ten Tusscher, Marcel

“…Emerging anticancer agents such as the pan-FGFR Inhibitor have achieved remarkable improvements in the survival of patients with metastatic malignancies…”
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The Relationship Between Tumor-Infiltrating Lymphocytes, PD-L1 Expression, Driver Mutations and Clinical Outcome Parameters in Non-Small Cell Lung Cancer Adenocarcinoma in Patients with a Limited to no Smoking History by Mignon, Sacha, Willard-Gallo, Karen, Van den Eynden, Gert, Salgado, Roberto, Decoster, Lore, Marien, Koen M., Vansteenkiste, Johan F., Teugels, Erik, De Grève, Jacques

“…Tumor infiltrating lymphocytes (TIL), programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) expression are important prognostic markers. This study…”
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Phase II Study of Preoperative Helical Tomotherapy for Rectal Cancer by De Ridder, Mark, M.D., Ph.D, Tournel, Koen, M.S, Van Nieuwenhove, Yves, M.D., Ph.D, Engels, Benedikt, M.D, Hoorens, Anne, M.D., Ph.D, Everaert, Hendrik, M.D., Ph.D, Op de Beeck, Bart, M.D, Vinh-Hung, Vincent, M.D., Ph.D, De Grève, Jacques, M.D., Ph.D, Delvaux, Georges, M.D., Ph.D, Verellen, Dirk, Ph.D, Storme, Guy A., M.D., Ph.D

“…Purpose To explore the efficacy and toxicity profile of helical tomotherapy in the preoperative treatment of patients with rectal cancer. Patients and Methods…”
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Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung cancer resistant to single EGFR blockade by Umelo, Ijeoma Adaku, De Wever, Olivier, Kronenberger, Peter, Van Deun, Jan, Noor, Alfiah, Singh, Kshitiz, Teugels, Erik, Chen, Gang, Bracke, Marc, De Grève, Jacques

“…KRAS is a frequently mutated oncogene in lung cancer and among the most refractory to EGFR targeted therapy. Recently, preclinical evidence in pancreatic…”
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Influence of RT-qPCR primer position on EGFR interference efficacy in lung cancer cells by Chen, Gang, Kronenberger, Peter, Teugels, Erik, De Grève, Jacques

“…Real-time quantitative RT-PCR (RT-qPCR) is a "gold" standard for measuring steady state mRNA levels in RNA interference assays. The knockdown of the epidermal…”
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