Search Results - "de Goede, Kyra E"

Metabolic Cancer-Macrophage Crosstalk in the Tumor Microenvironment by de Goede, Kyra E, Driessen, Amber J.M, Van den Bossche, Jan

“…Tumors consist of a wide variety of cells, including immune cells, that affect tumor progression. Macrophages are abundant innate immune cells in the tumor…”
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Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages by Harber, Karl J., de Goede, Kyra E., Verberk, Sanne G. S., Meinster, Elisa, de Vries, Helga E., van Weeghel, Michel, de Winther, Menno P. J., Van den Bossche, Jan

“…Immunometabolism revealed the crucial role of cellular metabolism in controlling immune cell phenotype and functions. Macrophages, key immune cells that…”
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Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling by Erkelens, Martje N, Goverse, Gera, Konijn, Tanja, Molenaar, Rosalie, Beijer, Marieke R, Van den Bossche, Jan, de Goede, Kyra E, Verberk, Sanne G S, de Jonge, Wouter J, den Haan, Joke M M, Mebius, Reina E

“…Tissue resident intestinal macrophages are known to exhibit an anti-inflammatory phenotype and produce little pro-inflammatory cytokines upon TLR ligation,…”
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Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques by Harber, Karl J., Neele, Annette E., van Roomen, Cindy PAA, Gijbels, Marion JJ, Beckers, Linda, Toom, Myrthe den, Schomakers, Bauke V., Heister, Daan AF, Willemsen, Lisa, Griffith, Guillermo R., de Goede, Kyra E., van Dierendonck, Xanthe AMH, Reiche, Myrthe E., Poli, Aurélie, L-H Mogensen, Frida, Michelucci, Alessandro, Verberk, Sanne GS, de Vries, Helga, van Weeghel, Michel, Van den Bossche, Jan, de Winther, Menno PJ

“…Inflammatory macrophages are key drivers of atherosclerosis that can induce rupture-prone vulnerable plaques. Skewing the plaque macrophage population towards…”
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Metabolic–epigenetic crosstalk in macrophage activation: an updated view by Verberk, Sanne Gs, de Goede, Kyra E, Van den Bossche, Jan

“…[...]macrophage activation is tightly controlled at different levels. [...]recent research with new genetic models challenges the common dogma that FAO…”
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Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes by Verberk, Sanne G S, van der Zande, Hendrik J P, Baardman, Jeroen, de Goede, Kyra E, Harber, Karl J, Keuning, Eelco D, Lambooij, Joost M, Otto, Frank, Zawistowska-Deniziak, Anna, de Vries, Helga E, de Winther, Menno P J, Guigas, Bruno, Van den Bossche, Jan

“…Macrophages are highly plastic, key regulators of inflammation. Deregulation of macrophage activation can lead to excessive inflammation as seen in…”
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Macrophages are metabolically heterogeneous within the tumor microenvironment by Geeraerts, Xenia, Fernández-Garcia, Juan, Hartmann, Felix J., de Goede, Kyra E., Martens, Liesbet, Elkrim, Yvon, Debraekeleer, Ayla, Stijlemans, Benoit, Vandekeere, Anke, Rinaldi, Gianmarco, De Rycke, Riet, Planque, Mélanie, Broekaert, Dorien, Meinster, Elisa, Clappaert, Emile, Bardet, Pauline, Murgaski, Aleksandar, Gysemans, Conny, Nana, Frank Aboubakar, Saeys, Yvan, Bendall, Sean C., Laoui, Damya, Van den Bossche, Jan, Fendt, Sarah-Maria, Van Ginderachter, Jo A.

“…Macrophages are often prominently present in the tumor microenvironment, where distinct macrophage populations can differentially affect tumor progression…”
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Let’s Enter the Wonderful World of Immunometabolites by de Goede, Kyra E., Harber, Karl J., Van den Bossche, Jan

“…Over the past decade, cancer metabolism research taught us that metabolites are much more than intermediate or end products of metabolism. As such, the name…”
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Rewiring of immune-metabolic crosstalk in the liver after viral infection by de Goede, Kyra E., Van den Bossche, Jan

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Monocyte and macrophage profiles in patients with inherited long-chain fatty acid oxidation disorders by Verberk, Sanne G.S., Hahn, Nico, Heister, Daan, Haverkamp, Jorien, Snelder, Khya S., de Goede, Kyra E., Gorki, Friederieke S., Hendriks, Jerome J.A., Houtkooper, Riekelt H., Visser, Gepke, Sjouke, Barbara, Langeveld, Mirjam, Van den Bossche, Jan

“…Patients with inherited disorders of the long-chain fatty acid oxidation (lcFAO) machinery present with a heterogeneous profile of disease manifestations and…”
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An integrated toolbox to profile macrophage immunometabolism by Verberk, Sanne G.S., de Goede, Kyra E., Gorki, Friederike S., van Dierendonck, Xanthe A.M.H., Argüello, Rafael J., Van den Bossche, Jan

“…Macrophages are dynamic immune cells that can adopt several activation states. Fundamental to these functional activation states is the regulation of cellular…”
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IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate by van Dierendonck, Xanthe A M H, de Goede, Kyra E, Van den Bossche, Jan

“…Isocitrate dehydrogenase (IDH) mutations produce high levels of the 'oncometabolite' R-2-hydroxyglutarate (R-2-HG) and play a key role in the initiation and…”
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Myeloid-Specific Acly Deletion Alters Macrophage Phenotype In Vitro and In Vivo without Affecting Tumor Growth by de Goede, Kyra E., Verberk, Sanne G. S., Baardman, Jeroen, Harber, Karl J., van Kooyk, Yvette, de Winther, Menno P. J., Schetters, Sjoerd T. T., Van den Bossche, Jan

“…Cancer cells rely on ATP-citrate lyase (Acly)-derived acetyl-CoA for lipid biogenesis and proliferation, marking Acly as a promising therapeutic target…”
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