Search Results - "de Giuli, Rita"

Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy by Nindl, Veronika, Maier, Reinhard, Ratering, David, De Giuli, Rita, Züst, Roland, Thiel, Volker, Scandella, Elke, Di Padova, Franco, Kopf, Manfred, Rudin, Markus, Rülicke, Thomas, Ludewig, Burkhard

“…Myocarditis is a potentially lethal inflammatory heart disease of children and young adults that frequently leads to dilated cardiomyopathy (DCM). Since…”
Get full text

An Inhibitor of HIV-1 Protease Modulates Proteasome Activity, Antigen Presentation, and T Cell Responses by Andre, Patrice, Groettrup, Marcus, Klenerman, Paul, De Giuli, Rita, Booth, Bruce L., Cerundolo, Vincenzo, Bonneville, Marc, Jotereau, Francine, Zinkernagel, Rolf M., Lotteau, Vincent

“…Inhibitors of the protease of HIV-1 have been used successfully for the treatment of HIV-1-infected patients and AIDS disease. We tested whether these protease…”
Get full text

How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity by Schmidtke, Gunter, Holzhütter, Hermann-Georg, Bogyo, Matthew, Kairies, Norman, Groll, Michael, de Giuli, Rita, Emch, Sabine, Groettrup, Marcus

“…The human immunodeficiency virus, type I protease inhibitor Ritonavir has been used successfully in AIDS therapy for 4 years. Clinical observations suggested…”
Get full text

Pronounced up‐regulation of the PA28α/β proteasome regulator but little increase in the steady‐state content of immunoproteasome during dendritic cell maturation by Macagno, Annalisa, Kuehn, Lothar, Giuli, Rita de, Groettrup, Marcus

“…Dendritic cells (DC) are professional antigen‐presenting cells that activate CTL by presenting MHC class I‐restricted peptides that are processed through the…”
Get full text

Cooperation of T h1 and T h17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy by Nindl, Veronika, Maier, Reinhard, Ratering, David, De Giuli, Rita, Züst, Roland, Thiel, Volker, Scandella, Elke, Di Padova, Franco, Kopf, Manfred, Rudin, Markus, Rülicke, Thomas, Ludewig, Burkhard

“…Myocarditis is a potentially lethal inflammatory heart disease of children and young adults that frequently leads to dilated cardiomyopathy ( DCM ). Since…”
Get full text

Immunoproteasomes Largely Replace Constitutive Proteasomes During an Antiviral and Antibacterial Immune Response in the Liver by Khan, Selina, van den Broek, Maries, Schwarz, Katrin, de Giuli, Rita, Diener, Pierre-Andre, Groettrup, Marcus

“…The proteasome is critically involved in the production of MHC class I-restricted T cell epitopes. Proteasome activity and epitope production are altered by…”
Get full text

A ubiquitin‐like protein which is synergistically inducible by interferon‐γ and tumor necrosis factor‐α by Raasi, Shahri, Schmidtke, Gunter, de Giuli, Rita, Groettrup, Marcus

“…A means of regulating the fate of intracellular proteins is their covalent conjugation to ubiquitin‐like proteins. A recently discovered ubiquitin‐like protein…”
Get full text

Cutting Edge: Neosynthesis Is Required for the Presentation of a T Cell Epitope from a Long-Lived Viral Protein by Khan, Selina, de Giuli, Rita, Schmidtke, Gunter, Bruns, Michael, Buchmeier, Michael, van den Broek, Maries, Groettrup, Marcus

“…CTLs recognize peptide epitopes which are proteolytically generated by the proteasome and presented on MHC class I molecules. According to the defective…”
Get full text

Molecular mapping of autoimmune B cell responses in experimental myocarditis by Krebs, Philippe, Kurrer, Michael O, Kremer, Marcel, De Giuli, Rita, Sonderegger, Ivo, Henke, Andreas, Maier, Reinhard, Ludewig, Burkhard

“…Abstract Autoimmune responses directed against heart-specific antigens most likely play a key role in the pathogenesis of myocarditis. Although autoantibodies…”
Get full text

The Selective Proteasome Inhibitors Lactacystin and Epoxomicin Can Be Used to Either Up- or Down-Regulate Antigen Presentation at Nontoxic Doses by Schwarz, Katrin, de Giuli, Rita, Schmidtke, Gunter, Kostka, Susanne, van den Broek, Maries, Kim, Kyung Bo, Crews, Craig M, Kraft, Regine, Groettrup, Marcus

“…The complete inhibition of proteasome activities interferes with the production of most MHC class I peptide ligands as well as with cellular proliferation and…”
Get full text

Quantification and characterization of myosin peptide-specific CD4 + T cells in autoimmune myocarditis by Maier, Reinhard, Miller, Simone, Kurrer, Michael, Krebs, Philippe, de Giuli, Rita, Kremer, Marcel, Scandella, Elke, Ludewig, Burkhard

“…Characterization of autoantigen-specific CD4 + T cells at the single cell level is crucial for understanding the immunopathological mechanisms underlying…”
Get full text

Structural plasticity of the proteasome and its function in antigen processing by Groettrup, M, van den Broek, M, Schwarz, K, Macagno, A, Khan, S, de Giuli, R, Schmidtke, G

“…The proteasome is the main provider of peptide ligands for major histocompatibility complex class I molecules. During an immune response to pathogens, the…”
Get full text

The Selective Proteasome Inhibitors Lactacystin and Epoxomicin Can Be Used to Either Up- or Down-Regulate Antigen Presentation at Nontoxic Doses1 by Schwarz, Katrin, Giuli, Rita de, Schmidtke, Gunter, Kostka, Susanne, van den Broek, Maries, Bo Kim, Kyung, Crews, Craig M., Kraft, Regine, Groettrup, Marcus

“…The complete inhibition of proteasome activities interferes with the production of most MHC class I peptide ligands as well as with cellular proliferation and…”
Get full text

The use of LCMV-specific T cell hybridomas for the quantitative analysis of MHC class I restricted antigen presentation by Schwarz, Katrin, van den Broek, Maries, de Giuli, Rita, Seelentag, Wolfhart W, Shastri, Nilabh, Groettrup, Marcus

Get full text

Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum by LEHNERT, M, DE GIULI, R, TWENTYMAN, P. R

“…Clinical studies of agents capable of reversing P-glycoprotein (Pgp)-mediated multidrug resistance have attracted much attention in recent years. One question…”
Get full text

Structural Plasticity of the Proteasome and Its Function in Antigen Processing by Groettrup, Marcus, van den Broek, Maries, Schwarz, Katrin, Macagno, Annalisa, Khan, Selina, de Giuli, Rita, Schmidtke, Gunter

Get full text