Search Results - "de Geus, Matthijs"

BERNN: Enhancing classification of Liquid Chromatography Mass Spectrometry data with batch effect removal neural networks by Pelletier, Simon J., Leclercq, Mickaël, Roux-Dalvai, Florence, de Geus, Matthijs B., Leslie, Shannon, Wang, Weiwei, Lam, TuKiet T., Nairn, Angus C., Arnold, Steven E., Carlyle, Becky C., Precioso, Frédéric, Droit, Arnaud

“…Liquid Chromatography Mass Spectrometry (LC-MS) is a powerful method for profiling complex biological samples. However, batch effects typically arise from…”
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Mass spectrometry in cerebrospinal fluid uncovers association of glycolysis biomarkers with Alzheimer’s disease in a large clinical sample by de Geus, Matthijs B., Leslie, Shannon N., Lam, TuKiet, Wang, Weiwei, Roux-Dalvai, Florence, Droit, Arnaud, Kivisakk, Pia, Nairn, Angus C., Arnold, Steven E., Carlyle, Becky C.

“…Alzheimer’s disease (AD) is a complex and heterogeneous neurodegenerative disorder with contributions from multiple pathophysiological pathways. One of the…”
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Autocatalytic Equation Describing the Change in Molecular Weight during Hydrolytic Degradation of Aliphatic Polyesters by Antheunis, Harro, van der Meer, Jan-Cees, de Geus, Matthijs, Heise, Andreas, Koning, Cor E

“…The autocatalytic equation derived in this study describes and even predicts the evolution of the number average molecular weight of aliphatic polyesters upon…”
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Polymers from Functional Macrolactones as Potential Biomaterials: Enzymatic Ring Opening Polymerization, Biodegradation, and Biocompatibility by van der Meulen, Inge, de Geus, Matthijs, Antheunis, Harro, Deumens, Ronald, Joosten, Elbert A. J, Koning, Cor E, Heise, Andreas

“…We systematically investigated a series of polymers derived from macrolactones, namely, pentadecalactone, hexadecalactone, and their unsaturated analogues…”
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Cerebrospinal fluid biomarker profiling of diverse pathophysiological domains in Alzheimer's disease by Trombetta, Bianca A., Wu, Chao‐Yi, Kuo, Evan, Geus, Matthijs B., Dodge, Hiroko H., Carlyle, Becky C., Kivisäkk, Pia, Arnold, Steven E.

“…INTRODUCTION While Alzheimer's disease (AD) is defined by amyloid‐β plaques and tau tangles in the brain, it is evident that many other pathophysiological…”
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Enzymatic polyester synthesis in ionic liquids by Marcilla, Rebeca, de Geus, Matthijs, Mecerreyes, David, Duxbury, Christopher J., Koning, Cor E., Heise, Andreas

“…The enzymatic synthesis of polyesters by ring-opening polymerization (ROP) and polycondensation in three ionic liquids, i.e., [bmim][Tf 2N], [bmim][PF 6] and…”
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Insights into the Initiation Process of Enzymatic Ring-Opening Polymerization from Monofunctional Alcohols Using Liquid Chromatography under Critical Conditions by Geus, Matthijs de, Peters, Ron, Koning, Cor E, Heise, Andreas

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Investigation of Factors Influencing the Chemoenzymatic Synthesis of Block Copolymers by de Geus, Matthijs, Peeters, Joris, Wolffs, Martin, Hermans, Thomas, Palmans, Anja R. A, Koning, Cor E, Heise, Andreas

“…The chemoenzymatic synthesis of block copolymers from a bifunctional initiator using enzymatic ring-opening polymerization (eROP) and ATRP in two consecutive…”
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Emergence of the ZNF675 Gene During Primate Evolution–Influenced Human Neurodevelopment Through Changing HES1 Autoregulation by Lodewijk, Gerrald A., Geus, Matthijs, Guimarães, Rita L. F. P., Jacobs, Frank M. J.

“…ABSTRACT In this study, we investigated recurrent copy number variations (CNVs) in the 19p12 locus, which are associated with neurodevelopmental disorders. The…”
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Mass spectrometry on cerebrospinal fluid uncovers association of novel glycolysis biomarkers with Alzheimer’s disease in a complex clinical cohort by de Geus, Matthijs B, Leslie, Shannon N, Wang, Weiwei, Lam, TuKiet, Broekman, Marike, Neefjes, Sjaak, Nairn, Angus C, Carlyle, Becky C., Arnold, Steven E.

“…Background Diagnosis of Alzheimer’s disease (AD) primarily relies on cognitive assessments supported by imaging and cerebrospinal fluid (CSF) biomarkers of…”
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Block copolymers by chemoenzymatic cascade polymerization: A comparison of consecutive and simultaneous reactions by de Geus, Matthijs, Schormans, Linda, Palmans, Anja R. A., Koning, Cor E., Heise, Andreas

“…The synthetic parameters for the chemoenzymatic cascade synthesis of block copolymers combining enzymatic ring‐opening polymerization (EROP) and atom transfer…”
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Applying Data‐Independent Acquisition Mass Spectrometry on Cerebrospinal Fluid Samples from a Neurology Clinic for Biomarker Discovery in Alzheimer’s Disease by de Geus, Matthijs B, Leslie, Shannon N, Ramirez, Christopher E., Trombetta, Bianca A., Wang, Weiwei, Lam, Tukiet, Gotti, Clarisse, Roux‐Dalvai, Florence, Droit, Arnaud, Nairn, Angus C, Arnold, Steven E., Carlyle, Becky C.

“…Background Diagnosis of Alzheimer’s disease (AD) primarily relies on cognitive assessments combined with imaging and limited fluid biomarkers. These biomarkers…”
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Using Proteomics Analysis to Identify Cerebrospinal Fluid Biomarkers in Normal Pressure Hydrocephalus by LaCasse, Kathryn, de Geus, Matthijs B, Trombetta, Bianca A., Ramirez, Christopher E., El‐Mufti, Leena H., Riley, Misha M., McManus, Alison J., Wills, Anne‐Marie, Kivisäkk, Pia, Carlyle, Becky C., Arnold, Steven E.

“…Background Normal Pressure Hydrocephalus (NPH) is a neurological condition where there is enlarged ventricular size with normal opening pressure at lumbar…”
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Improved Mathematical Model for the Hydrolytic Degradation of Aliphatic Polyesters by Antheunis, Harro, van der Meer, Jan-Cees, de Geus, Matthijs, Kingma, Wieb, Koning, Cor E

“…The objective of this study was to develop a mathematical model that describes and even predicts the hydrolytic degradation of aliphatic polyesters. From…”
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Controlled formation of poly(ε-caprolactone) ultrathin electrospun nanofibers in a hydrolytic degradation-assisted process by Lavielle, Nicolas, Popa, Ana-Maria, de Geus, Matthijs, Hébraud, Anne, Schlatter, Guy, Thöny-Meyer, Linda, Rossi, René M.

“…[Display omitted] •PCL nanofiber morphology-dimension is controlled using hydrolytic degradation.•Bead-free PCL nanofiber diameter is tuned from 150 to…”
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Effect of PLA crystallization on the structure of biomimetic composites of PLA and clay by Boesel, Luciano F., de Geus, Matthijs, Thöny-Meyer, Linda

“…Composites of poly(lactic acid) (PLA) and organoclays with clay loadings of up to 80% were prepared as self‐supporting films using a doctor‐blading approach…”
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Can Block Copolymers Be Synthesized by a Single-Step Chemoenzymatic Route in Supercritical Carbon Dioxide? by Duxbury, Christopher J, Wang, Wenxin, de Geus, Matthijs, Heise, Andreas, Howdle, Steven M

“…We demonstrate the single-step one-pot synthesis of block copolymers by simultaneous enzymatic ring-opening polymerization and chemically catalyzed atom…”
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Stimuli Responsive Peptide Conjugated Polymer Nanoparticles by Knoop, Rutger J. I, de Geus, Matthijs, Habraken, Gijs J. M, Koning, Cor E, Menzel, Henning, Heise, Andreas

“…We have investigated a novel approach to well-defined peptide-decorated cross-linked nanoparticles. The particles were obtained from well-defined…”
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Monitoring the hygrothermal response of poly(vinyl methyl ether) submicron films using AFM by Lübben, Jörn F., Crespy, Daniel, de Geus, Matthijs, Heuberger, Manfred

“…Films with submicron thickness of the thermoresponsive polymer poly(vinyl methyl ether) (PVME) are prepared by spin-coating and measured with AFM. The change…”
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