High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome

High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome

To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients with metabolic syndrome (MetS). Serum levels of 372 miRNAs were measured in patients with (n = 6) and without MetS (n = 6) by quantitative PCR array, and dysregulated miRNAs were...

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Published in:Epigenomics Vol. 13; no. 6; pp. 423 - 436
Main Authors: Braga, Aécio A, Bortolin, Raul H, Graciano-Saldarriaga, Magda E, Hirata, Thiago Dc, Cerda, Alvaro, de Freitas, Renata Cc, Lin-Wang, Hui T, Borges, Jessica B, França, João Id, Masi, Laureane N, Curi, Rui, Pithon-Curi, Tania C, Sampaio, Marcelo F, Castro, Lara R, Bastos, Gisele M, Hirata, Rosario Dc, Hirata, Mario H
Format: Journal Article
Language:English
Published: England Future Medicine Ltd 01-03-2021
Subjects:
adiponectin
Adult
Aged
Aged, 80 and over
Biomarkers - blood
C-Reactive Protein - analysis
circulating miRNAs
Female
Follow-Up Studies
Gene Expression Regulation
Humans
inflammation
Inflammation - blood
Inflammation - etiology
Inflammation - pathology
Insulin Resistance
Male
metabolic syndrome
Metabolic Syndrome - complications
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
miR-421
obesity
Prognosis
Resistin - blood
Triglycerides - blood
metabolic syndrome
miR-421
adiponectin
inflammation
circulating miRNAs
insulin resistance
obesity
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Summary:To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients with metabolic syndrome (MetS). Serum levels of 372 miRNAs were measured in patients with (n = 6) and without MetS (n = 6) by quantitative PCR array, and dysregulated miRNAs were validated in a larger cohort (MetS, n = 89; non-MetS, n = 144). In the screening study, seven miRNAs were dysregulated in patients with MetS, and miR-421 remained increased in the validation study. miR-421 was associated with a high risk of MetS and insulin resistance and hypertension and correlated with glycated hemoglobin, triacylglycerols, high-sensitivity CRP, IL-6, resistin and adiponectin (p < 0.05). Circulating miR-421 is a potential biomarker for insulin resistance, metabolic dysregulation and inflammatory status in patients with MetS. This study aimed to explore the association of circulating regulatory small molecules (miRNAs) with obesity, metabolic alterations and inflammation in patients with metabolic syndrome (MetS). Levels of 372 miRNAs were measured in blood serum of patients with and without MetS using molecular biology techniques. Seven miRNAs were altered in patients with MetS, and one of them (miR-421) was associated with a high risk of MetS, insulin resistance and hypertension. miR-421 was also correlated with glycated hemoglobin (used for glycemia monitoring), serum lipids and inflammatory molecules. Circulating miR-421 is a small molecule with potential biomarker for insulin resistance, metabolic dysregulation and inflammatory status in patients with MetS.
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ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2020-0247