Search Results - "de Doncker, S"

Evaluation of an in vitro and in vivo model for experimental infection with Leishmania (Viannia) braziliensis and L. (V.) peruviana by Gamboa, D, Torres, K, De Doncker, S, Zimic, M, Arevalo, J, Dujardin, J-C

“…Leishmania (Viannia) braziliensis and L. (V.) peruviana are two parasite species characterized by a very different pathogenicity in humans despite a high…”
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Heat-shock protein 70 gene sequencing for Leishmania species typing in European tropical infectious disease clinics by Van der Auwera, G, Maes, I, De Doncker, S, Ravel, C, Cnops, L, Van Esbroeck, M, Van Gompel, A, Clerinx, J, Dujardin, J C

“…We describe Leishmania species determination on clinical samples on the basis of partial sequencing of the heat-shock protein 70 gene (hsp70), without the need…”
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Clinical and Parasite Species Risk Factors for Pentavalent Antimonial Treatment Failure in Cutaneous Leishmaniasis in Peru by Llanos-Cuentas, Alejandro, Tulliano, Gianfranco, Araujo-Castillo, Roger, Miranda-Verastegui, Cesar, Santamaria-Castrellon, Giovanna, Ramirez, Luis, Lazo, Marcela, De Doncker, Simonne, Boelaert, Marleen, Robays, Jo, Dujardin, Jean-Claude, Arevalo, Jorge, Chappuis, Francois

“…Background. Treatment for cutaneous leishmaniasis (CL) with standard pentavalent antimonial therapy is hampered by cumbersome administration, toxicity, and…”
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Universal PCR assays for the differential detection of all Old World Leishmania species by Ogado Ceasar Odiwuor, S, Ageed Saad, A, De Doncker, S, Maes, I, Laurent, T, El Safi, S, Mbuchi, M, Büscher, P, Dujardin, J.-C, Van der Auwera, G

“…For the epidemiological monitoring and clinical case management of leishmaniasis, determination of the causative Leishmania species gains importance. Current…”
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Heat-shock protein 70 PCR-RFLP: a universal simple tool for Leishmania species discrimination in the New and Old World by Montalvo, A M, Fraga, J, Monzote, L, Montano, I, De Doncker, S, Dujardin, J C, Van der Auwera, G

“…Species typing in leishmaniasis gains importance in diagnostics, epidemiology, and clinical studies. A restriction fragment length polymorphism (RFLP) assay of…”
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Molecular epidemiology and diagnosis of Leishmania: what have we learnt from genome structure, dynamics and function? by Dujardin, J.C., Victoir, K., De Doncker, S., Guerbouj, S., Arévalo, J., Le Ray, D.

“…This paper reviews our exploration of the dynamics of the Leishmania genome and its contribution to epidemiology and diagnosis. We used as a model Peruvian…”
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American tegumentary leishmaniasis: antigen-gene polymorphism, taxonomy and clinical pleomorphism by Garcia, A.L., Kindt, A., Quispe-Tintaya, K.W., Bermudez, H., Llanos, A., Arevalo, J., Bañuls, A.L., De Doncker, S., Le Ray, D., Dujardin, J.C.

“…Multi-locus enzyme electrophoresis is the current gold standard for the genetic characterisation of Leishmania. However, this method is time-consuming and,…”
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In vitro promastigote fitness of putative Leishmania (Viannia) braziliensis/ Leishmania (Viannia) peruviana hybrids by Torrico, M.C, De Doncker, S, Arevalo, J, Le Ray, D, Dujardin, J.C

“…In order to initiate studies on the phenotypic properties of hybrids vs. their putative parents, the in vitro growth behaviour of promastigotes was compared…”
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Evolutionary history of Trypanosoma cruzi according to antigen genes by Rozas, M, De Doncker, S, Coronado, X, Barnabé, C, Tibyarenc, M, Solari, A, Dujardin, J-C

“…Trypanosoma cruzi, the agent of Chagas disease is associated with a very high clinical and epidemiological pleomorphism. This might be better understood…”
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Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation by Decuypere, S, Vanaerschot, M, Rijal, S, Yardley, V, Maes, L, de Doncker, S, Chappuis, F, Dujardin, J-C

“…Gene expression profiling is increasingly used in the field of infectious diseases for characterization of host, pathogen and the nature of their interaction…”
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Size-polymorphism of mini-exon gene-bearing chromosomes among natural populations of Leishmania, subgenus Viannia by Kebede, A, De Doncker, S, Arevalo, J, Le Ray, D, Dujardin, J.C

“…In order to explore genomic plasticity at the level of the mini-exon gene-bearing chromosome in natural populations of Leishmania, the molecular karyotype of…”
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Identification of Lebanese dermotropic putative Leishmania archibaldi isolates by gp63 PCR-RFLP by Guerbouj, S., Guizani, I., De Doncker, S., Dujardin, J.C., Nuwayri-Salti, N.

“…Leishmania stocks isolated from cutaneous lesions in Lebanon were characterized by PCR methods. The stocks were typed as putative L. (L.) archibaldi (gp63…”
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Increased metacyclogenesis of antimony-resistant Leishmania donovani clinical lines by Ouakad, M, Vanaerschot, M, Rijal, S, Sundar, S, Speybroeck, N, Kestens, L, Boel, L, De Doncker, S, Maes, I, Decuypere, S, Dujardin, J-C

“…Mathematical models predict that the future of epidemics of drug-resistant pathogens depends in part on the competitive fitness of drug-resistant strains…”
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Complexity of the major surface protease (msp) gene organization in Leishmania (Viannia) braziliensis: evolutionary and functional implications by Victoir, K, Arevalo, J, De Doncker, S, Barker, D C, Laurent, T, Godfroid, E, Bollen, A, Le Ray, D, Dujardin, J C

“…The major surface protease (msp or gp63) of Leishmania plays a major role in the host-parasite interaction. We analysed here the structure of the msp gene…”
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Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony by Adaui, V, Schnorbusch, K, Zimic, M, Gutiérrez, A, Decuypere, S, Vanaerschot, M, DE Doncker, S, Maes, I, Llanos-Cuentas, A, Chappuis, F, Arévalo, J, Dujardin, J-C

“…Evaluation of Leishmania drug susceptibility depends on in vitro Sb(V) susceptibility assays, which are labour-intensive and may give a biased view of the true…”
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Influence of Leishmania (Viannia) Species on the Response to Antimonial Treatment in Patients with American Tegumentary Leishmaniasis by Arevalo, Jorge, Ramirez, Luis, Adaui, Vanessa, Zimic, Mirko, Tulliano, Gianfranco, Miranda-Verástegui, César, Lazo, Marcela, Loayza-Muro, Raúl, De Doncker, Simonne, Maurer, Anne, Chappuis, Francois, Dujardin, Jean-Claude, Llanos-Cuentas, Alejandro

“…Background. Pentavalent antimonials (SbV) are the first-line chemotherapy for American tegumentary leishmaniasis (ATL). There are, however, reports of the…”
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Extreme inbreeding in Leishmania braziliensis by Rougeron, Virginie, De Meeûs, Thierry, Hide, Mallorie, Waleckx, Etienne, Bermudez, Herman, Arevalo, Jorge, Llanos-Cuentas, Alejandro, Dujardin, Jean-Claude, De Doncker, Simone, Le Ray, Dominique, Ayala, Francisco J, Bañuls, Anne-Laure

“…Leishmania species of the subgenus Viannia and especially Leishmania braziliensis are responsible for a large proportion of New World leishmaniasis cases. The…”
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A new focus of cutaneous leishmaniasis due to Leishmania amazonensis in a Sub Andean region of Bolivia by Martı́nez, E, Le Pont, F, Torrez, M, Tellerı́a, J, Vargas, F, Muñoz, M, De Doncker, S, Dujardin, J.C, Dujardin, J.P

“…We detected a new outbreak focus with high incidence of cutaneous leishmaniasis in the Sub Andean region of La Paz. This area was never considered previously…”
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Plasticity of gp63 gene organization in Leishmania (Viannia) braziliensis and Leishmania (Viannia) peruviana by Victoir, K, Dujardin, J C, de Doncker, S, Barker, D C, Arevalo, J, Hamers, R, Le Ray, D

“…The genomic organization of gp63 genes in 4 and 7 isolates of Leishmania braziliensis and L. peruviana, respectively was studied by RFLP analysis with 3…”
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Development and evaluation of different PCR-based typing methods for discrimination of Leishmania donovani isolates from Nepal by Bhattarai, N R, Dujardin, J C, Rijal, S, De Doncker, S, Boelaert, M, Van der Auwera, G

“…Leishmania donovani, the causative agent of visceral leishmaniasis in the Indian subcontinent, has been reported to be genetically homogeneous. In order to…”
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