Search Results - "de Dios, Angel C"

Cytostatic versus Cytocidal Activities of Chloroquine Analogues and Inhibition of Hemozoin Crystal Growth by GORKA, Alexander P, ALUMASA, John N, SHERLACH, Katy S, JACOBS, Lauren M, NICKLEY, Katherine B, BROWER, Jonathan P, DE DIOS, Angel C, ROEPE, Paul D

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Relative to Quinine and Quinidine, Their 9-Epimers Exhibit Decreased Cytostatic Activity and Altered Heme Binding but Similar Cytocidal Activity versus Plasmodium falciparum by GORKA, Alexander P, SHERLACH, Katy S, DE DIOS, Angel C, ROEPE, Paul D

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The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex by Alumasa, John N., Gorka, Alexander P., Casabianca, Leah B., Comstock, Erica, de Dios, Angel C., Roepe, Paul D.

“…Quinoline antimalarial drugs bind both monomeric and dimeric forms of free heme, with distinct preferences depending on the chemical environment. Under…”
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Quinine and Chloroquine Differentially Perturb Heme Monomer−Dimer Equilibrium by Casabianca, Leah B, An, David, Natarajan, Jayakumar K, Alumasa, John N, Roepe, Paul D, Wolf, Christian, Dios, Angel C. de

“…Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs…”
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Solution Structures of Antimalarial Drug−Heme Complexes by Leed, Alison, DuBay, Kateri, Ursos, Lyann M. B, Sears, Devin, de Dios, Angel C, Roepe, Paul D

“…Paramagnetic metal centers [such as FeIII found within ferriprotoporphyrin IX heme (FPIX)] exert through space effects on the relaxation rate of nearby proton…”
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Secondary and Tertiary Structural Effects on Protein NMR Chemical Shifts: An ab Initio Approach by de Dios, Angel C., Pearson, John G., Oldfield, Eric

“…Recent theoretical developments permit the prediction of $^1$H, $^{13}$C, $^{15}$N, and $^{19}$F nuclear magnetic resonance chemical shifts in proteins and…”
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Artesunate activation by heme in an aqueous medium by Heller, Laura, Roepe, Paul D., de Dios, Angel C.

“…Monitoring artesunate protons by nuclear magnetic resonance spectroscopy provides a means for measuring the activation of this drug by reduced heme. The…”
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4-N-, 4-S-, and 4-O-Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pK a on Activity vs Chloroquine Resistant Malaria by Natarajan, Jayakumar K, Alumasa, John N, Yearick, Kimberly, Ekoue-Kovi, Kekeli A, Casabianca, Leah B, de Dios, Angel C, Wolf, Christian, Roepe, Paul D

“…Using predictions from heme−quinoline antimalarial complex structures, previous modifications of chloroquine (CQ), and hypotheses for chloroquine resistance…”
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13C NMR Study of the Self-Association of Chloroquine, Amodiaquine, and Quinine by Casabianca, Leah B, de Dios, Angel C

“…Experimental and calculated 13C NMR chemical shifts of quinoline ring carbons are used to investigate the self-association of the antimalarial drugs…”
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Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain by Iwaniuk, Daniel P., Whetmore, Eric D., Rosa, Nicholas, Ekoue-Kovi, Kekeli, Alumasa, John, de Dios, Angel C., Roepe, Paul D., Wolf, Christian

“…We report the synthesis and in vitro antimalarial activity of several new 4-amino- and 4-alkoxy-7-chloroquinolines carrying a linear dibasic side chain. Many…”
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Ab initio calculations of the NMR chemical shift by de Dios, Angel C.

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4-N-, 4-S-, and 4-O-Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs Chloroquine Resistant Malaria by NATARAJAN, Jayakumar K., ALUMASA, John N., YEARICK, Kimberly, EKOUE-KOVI, Kekeli A., CASABIANCA, Leah B., DE DIOS, Angel C., WOLF, Christian, ROEPE, Paul D.

“…Using predictions from heme-quinoline antimalarial complex structures, previous modifications of chloroquine (CQ), and hypotheses for chloroquine resistance…”
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Antimalarial drugs and heme in detergent micelles: An NMR study by Casabianca, Leah B., Kallgren, Joye B., Natarajan, Jayakumar K., Alumasa, John N., Roepe, Paul D., Wolf, Christian, de Dios, Angel C.

“…Proton nuclear magnetic resonance relaxation times were measured for the protons of micelles formed by the detergents sodium dodecyl sulfate, dodecyltrimethyl…”
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Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas by Ekoue-Kovi, Kekeli, Yearick, Kimberly, Iwaniuk, Daniel P., Natarajan, Jayakumar K., Alumasa, John, de Dios, Angel C., Roepe, Paul D., Wolf, Christian

“…More than 50 new chloroquine analogues exhibiting systematically varied side chains have been synthesized and tested against sensitive and resistant strains of…”
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13C NMR Spectroscopy of 13C1-Labeled Octanethiol-Protected Au Nanoparticles:  Shifts, Relaxations, and Particle-Size Effect by Zelakiewicz, Brian S, de Dios, Angel C, Tong

“…We report here an investigation of metal−ligand interactions in nanoparticles with 13C NMR, using a labeled 13C1-octanethiol, a protecting ligand for…”
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Overcoming Drug Resistance to Heme-Targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines by Yearick, Kimberly, Ekoue-Kovi, Kekeli, Iwaniuk, Daniel P, Natarajan, Jayakumar K, Alumasa, John, de Dios, Angel C, Roepe, Paul D, Wolf, Christian

“…Systematic variation of the branching and basicity of the side chain of chloroquine yielded a series of new 7-chloro-4-aminoquinoline derivatives exhibiting…”
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Synthesis, larvicidal, QSAR and structural studies of some triorganotin 2,2,3,3-tetramethylcyclopropanecarboxylates by Song, Xueqing, Zapata, Alejandra, Hoerner, Jana, de Dios, Angel C., Casabianca, Leah, Eng, George

“…A series of triorganotin 2,2,3,3‐tetramethylcyclopropanecarboxylates, where R = methyl, ethyl, n‐propyl, n‐butyl, phenyl and cyclohexyl, have been synthesized…”
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Structure of the Amodiaquine−FPIX μ Oxo Dimer Solution Complex at Atomic Resolution by de Dios, Angel C, Casabianca, Leah B, Kosar, Andrew, Roepe, Paul D

“…Using NMR inversion recovery experiments and XPLOR distance restraint calculations, we recently deduced the structure of ferriprotoporphyrin IX (FPIX) heme μ…”
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Synthesis, structural and larvicidal studies of a series of triorganotin chrysanthemumates by Zapata, Alejandra, Mclean, Diane P., Delao Hernández, José H., de Dios, Angel C., Song, Xueqing, Eng, George

“…A series of triorganotin chrysanthemumates (2,2‐dimethyl‐3‐(2‐methyl‐1‐propenyl)cyclopropanecarboxylates) (R3SnO2CC9H15) where R = methyl, ethyl, n‐butyl and…”
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Solid-State 15N NMR Chemical Shift Anisotropy of Histidines:  Experimental and Theoretical Studies of Hydrogen Bonding by Wei, Yufeng, de Dios, Angel C, McDermott, Ann E

“…The principal values of the 15N chemical shift tensors of crystalline histidine and histidine-containing peptides have been measured to document for the first…”
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