Search Results - "de Diego, J. Eugenio"

The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future by Mennen, Steven M, Alhambra, Carolina, Allen, C. Liana, Barberis, Mario, Berritt, Simon, Brandt, Thomas A, Campbell, Andrew D, Castañón, Jesús, Cherney, Alan H, Christensen, Melodie, Damon, David B, Eugenio de Diego, J, García-Cerrada, Susana, García-Losada, Pablo, Haro, Rubén, Janey, Jacob, Leitch, David C, Li, Ling, Liu, Fangfang, Lobben, Paul C, MacMillan, David W. C, Magano, Javier, McInturff, Emma, Monfette, Sebastien, Post, Ronald J, Schultz, Danielle, Sitter, Barbara J, Stevens, Jason M, Strambeanu, Iulia I, Twilton, Jack, Wang, Ke, Zajac, Matthew A

“…High-throughput experimentation (HTE) has revolutionized the pharmaceutical industry, most notably allowing for rapid screening of compound libraries against…”
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Aminoimidazo[1,2- a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation by Jaramillo, Carlos, de Diego, J. Eugenio, Hamdouchi, Chafiq, Collins, Elizabeth, Keyser, Heather, Sánchez-Martı́nez, Concha, del Prado, Miriam, Norman, Bryan, Brooks, Harold B., Watkins, Scott A., Spencer, Charles D., Dempsey, Jack Alan, Anderson, Bryan D., Campbell, Robert M., Leggett, Tellie, Patel, Bharvin, Schultz, Richard M., Espinosa, Juan, Vieth, Michal, Zhang, Faming, Timm, David E.

“…Synthesis of 2-aminoimidazo[1,2- a]pyridines 1 and their evaluation as CDK2 inhibitors is described. We have identified a novel structural class of protein…”
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Synthesis of 2‘-Alkylspiro[2-X-cyclohexan-1,3‘-3‘H-indole] (X = H; X = CH3) by an Unexpected Reaction between an Organomagnesium Halide and 2‘-Methylspiro[2-X-cyclohexan-1,3‘-3‘H-indole]. X-ray Structure of a Fluorescent Dimeric Compound by Rodríguez, J. Gonzalo, Urrutia, Anahí, Eugenio de Diego, J, Paz Martínez-Alcazar, M, Fonseca, I

“…The reaction of 2‘-methylspiro[cyclohexan-1,3‘-3‘H-indole] (1a) with methylmagnesium iodide gives 2‘-ethyl-, 2‘-isopropyl-, and…”
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Regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2- a]pyridines by Jaramillo, Carlos, Carretero, Juan Carlos, de Diego, J.Eugenio, del Prado, Miriam, Hamdouchi, Chafiq, Roldán, José Luis, Sánchez-Martı́nez, Concha

“…A convenient synthesis of 3,6-disubstituted-2-aminoimidazo[1,2- a]pyridines 3 is described. A halogen–metal exchange study on building block 1 showed that use…”
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New approach to the stereoselective synthesis of the [4.5] spiroketal moiety of papulacandins by Canetero, Juan C., de Diego, J.Eugenio, Hamdouchi, Chafiq

“…An efficient approach for the stereoselective construction of the spiroketal moiety of papulacandins, based on the condensation of the protected derivative of…”
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