Search Results - "de Diego, Cristina"
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Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians
Published in Lab on a chip (27-09-2022)“…Neovascularization, the formation of new blood vessels, has received much research attention due to its implications for physiological processes and diseases…”
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Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer
Published in International journal of molecular sciences (19-01-2017)“…Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death. Most cases of CRC are detected in Western…”
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Dental Stem Cells SV40, a new cell line developed in vitro from human stem cells of the apical papilla
Published in International endodontic journal (01-04-2023)“…Aim To establish and fully characterize a new cell line from human stem cells of the apical papilla (SCAPs) through immortalization with an SV40 large T…”
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Inhibition of phosphatidylinositol 3‐kinase α (PI3Kα) prevents heterotopic ossification
Published in EMBO molecular medicine (01-09-2019)“…Heterotopic ossification (HO) is the pathological formation of ectopic endochondral bone within soft tissues. HO occurs following mechanical trauma, burns, or…”
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Therapeutic Applications of Rose Hips from Different Rosa Species
Published in International journal of molecular sciences (25-05-2017)“…species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The…”
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NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression
Published in Redox biology (01-04-2021)“…Osteocytes, the most abundant bone cell type, are derived from osteoblasts through a process in which they are embedded in an osteoid. We previously showed…”
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p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation
Published in Cell death and differentiation (01-12-2017)“…Osteoblast differentiation is achieved by activating a transcriptional network in which Dlx5 , Runx2 and Osx/SP7 have fundamental roles. The tumour suppressor…”
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TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology
Published in International journal of molecular sciences (17-12-2014)“…Thioredoxin domain-containing 5 (TXNDC5) is a member of the protein disulfide isomerase family, acting as a chaperone of endoplasmic reticulum under not fully…”
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Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure
Published in Scientific reports (14-03-2023)“…The aging-protective gene α-Klotho (KL) produces two main transcripts. The full-length mRNA generates a transmembrane protein that after proteolytic ectodomain…”
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ACVR1 Function in Health and Disease
Published in Cells (Basel, Switzerland) (31-10-2019)“…encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including…”
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Engineering a Microphysiological Model for Regenerative Endodontic Studies
Published in Biology (Basel, Switzerland) (01-04-2024)“…Dental pulp infections are common buccal diseases. When this happens, endodontic treatments are needed to disinfect and prepare the root canal for subsequent…”
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HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling
Published in Cell death & disease (12-01-2023)“…Bone remodeling is a continuous process between bone-forming osteoblasts and bone-resorbing osteoclasts, with any imbalance resulting in metabolic bone…”
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The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells
Published in International journal of molecular sciences (08-02-2022)“…Hyperactivation of the KEAP1-NRF2 axis is a common molecular trait in carcinomas from different origin. The transcriptional program induced by NRF2 involves…”
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Local disconnects in global discourses—The unintended consequences of marine mammal protection on small‐scale fishers
Published in Conservation letters (01-11-2021)“…Global commitments prioritize protection of wildlife and improvements to human wellbeing. Local disconnects in these commitments are rarely acknowledged—or…”
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Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology
Published in Biomolecules (Basel, Switzerland) (26-09-2019)“…The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs)…”
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Drivers of adoption and spread of wildlife management initiatives in Mexico
Published in Conservation science and practice (01-07-2021)“…Conservation initiatives rarely achieve the scale required to respond to ongoing biodiversity loss. Understanding what drives the adoption of conservation…”
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Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program
Published in iScience (31-05-2019)“…Osteocytes, the most abundant of bone cells, differentiate while they remain buried within the bone matrix. This encasement limits their access to nutrients…”
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Alkynyl gold(I) complex triggers necroptosis via ROS generation in colorectal carcinoma cells
Published in Journal of inorganic biochemistry (01-11-2017)“…Given the rise of apoptosis-resistant tumors, there exist a growing interest in developing new drugs capable of inducing different types of cell death to…”
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Characterization of the Immune Response Induced by a Commercially Available Inactivated Bluetongue Virus Serotype 1 Vaccine in Sheep
Published in TheScientificWorld (01-01-2012)“…The protective immune response generated by a commercial monovalent inactivated vaccine against bluetongue virus serotype 1 (BTV1) was studied. Five sheep were…”
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Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss
Published in Molecular therapy (02-08-2023)“…Age-related and chemotherapy-induced bone loss depends on cellular senescence and the cell secretory phenotype. However, the factors secreted in the senescent…”
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