Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors

The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms underlying proper lamination of the developing mammalian cerebral cortex. In this report, we identify a component of the regulation of Cdk5-medi...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 295; no. 5559; pp. 1528 - 1532
Main Authors:	McEvilly, Robert J., de Diaz, Marcela Ortiz, Schonemann, Marcus D., Hooshmand, Farideh, Rosenfeld, Michael G.
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for the Advancement of Science 22-02-2002 American Association for the Advancement of Science The American Association for the Advancement of Science
Subjects:	Animal migration behavior Animals Biological and medical sciences Biology Brain Brain - cytology Brain - embryology Brain - metabolism Brn-1 protein Cdk5 protein Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cell Line Cell Movement Cerebral cortex Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - metabolism Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinases - metabolism Development. Senescence. Regeneration. Transplantation Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female Fundamental and applied biological sciences. Psychology Gene Targeting Genetic aspects Genetic regulation Genetic transcription Hippocampus Hippocampus - cytology Hippocampus - embryology Hippocampus - metabolism Homeodomain Proteins In Situ Hybridization Laminates Male Messenger RNA Mice Migration Molecules Mutation Neocortex Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Neurons - physiology Neuropeptides - genetics Neuropeptides - physiology POU Domain Factors Regulation Serine Endopeptidases Trans-Activators - genetics Trans-Activators - physiology Transcription (Genetics) Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic Vertebrates: nervous system and sense organs United States Vertebrata Cerebral cortex Regulation(control) Mammalia Transcription Central nervous system Development POU Domain Brain (vertebrata)
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Summary:	The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms underlying proper lamination of the developing mammalian cerebral cortex. In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons. Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons, with Brn-1(-/-)/Brn-2(-/-)mice exhibiting cortical inversion.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1067132