Search Results - "de Clare, Michaela"

Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae by de Clare, Michaela, Oliver, Stephen G

“…Copy-number variation (CNV), rather than complete loss of gene function, is increasingly implicated in human disease. Moreover, gene dosage is recognised as…”
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Haploinsufficiency and the sex chromosomes from yeasts to humans by de Clare, Michaela, Pir, Pınar, Oliver, Stephen G

“…Haploinsufficient (HI) genes are those for which a reduction in copy number in a diploid from two to one results in significantly reduced fitness…”
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Yeast-based automated high-throughput screens to identify anti-parasitic lead compounds by Bilsland, Elizabeth, Sparkes, Andrew, Williams, Kevin, Moss, Harry J., de Clare, Michaela, Pir, Pınar, Rowland, Jem, Aubrey, Wayne, Pateman, Ron, Young, Mike, Carrington, Mark, King, Ross D., Oliver, Stephen G.

“…We have developed a robust, fully automated anti-parasitic drug-screening method that selects compounds specifically targeting parasite enzymes and not their…”
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Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases by Williams, Kevin, Bilsland, Elizabeth, Sparkes, Andrew, Aubrey, Wayne, Young, Michael, Soldatova, Larisa N., De Grave, Kurt, Ramon, Jan, de Clare, Michaela, Sirawaraporn, Worachart, Oliver, Stephen G., King, Ross D.

“…There is an urgent need to make drug discovery cheaper and faster. This will enable the development of treatments for diseases currently neglected for economic…”
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Control analysis of the eukaryotic cell cycle using gene copy-number series in yeast tetraploids by Alcasabas, Annette A, de Clare, Michaela, Pir, Pınar, Oliver, Stephen G

“…In the model eukaryote, Saccharomyces cerevisiae, previous experiments have identified those genes that exert the most significant control over cell growth…”
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