Search Results - "de Ceballos, María L"

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation by Innamorato, Nadia G, Rojo, Ana I, Garcia-Yague, Angel J, Yamamoto, Masayuki, de Ceballos, Maria L, Cuadrado, Antonio

“…Because chronic neuroinflammation is a hallmark of neurodegenerative diseases and compromises neuron viability, it is imperative to discover pharmacologic…”
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Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation by Ramirez, Belen G, Blazquez, Cristina, del Pulgar, Teresa Gomez, Guzman, Manuel, de Ceballos, Maria L

“…Alzheimer's disease (AD) is characterized by enhanced beta-amyloid peptide (betaA) deposition along with glial activation in senile plaques, selective neuronal…”
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Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice by Martín-Moreno, Ana María, Brera, Begoña, Spuch, Carlos, Carro, Eva, García-García, Luis, Delgado, Mercedes, Pozo, Miguel A, Innamorato, Nadia G, Cuadrado, Antonio, de Ceballos, María L

“…Alzheimer's disease (AD) brain shows an ongoing inflammatory condition and non-steroidal anti-inflammatories diminish the risk of suffering the neurologic…”
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Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes by Pajares, Marta, Jiménez-Moreno, Natalia, García-Yagüe, Ángel J., Escoll, Maribel, de Ceballos, María L., Van Leuven, Fred, Rábano, Alberto, Yamamoto, Masayuki, Rojo, Ana I., Cuadrado, Antonio

“…Autophagy is a highly coordinated process that is controlled at several levels including transcriptional regulation. Here, we identify the transcription factor…”
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The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis by Pérez-Domper, Paloma, Palomo, Valle, Gradari, Simona, Gil, Carmen, de Ceballos, María L., Martínez, Ana, Trejo, Jose Luis

“…Glycogen synthase kinase 3 (GSK-3) is a constitutively active kinase that has been implicated in the mechanism of action of mood stabilizers. According to the…”
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Boosting brain glucose metabolism to fight neurodegeneration? by de Ceballos, María L, Köfalvi, Attila

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Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease by Martín-Moreno, Ana María, Reigada, David, Ramírez, Belén G, Mechoulam, R, Innamorato, Nadia, Cuadrado, Antonio, de Ceballos, María L

“…Microglial activation is an invariant feature of Alzheimer's disease (AD). It is noteworthy that cannabinoids are neuroprotective by preventing β-amyloid…”
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Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease by Rojo, Ana I., Innamorato, Nadia G., Martín-Moreno, Ana M., De Ceballos, María L., Yamamoto, Masayuki, Cuadrado, Antonio

“…Neural injury leads to inflammation and activation of microglia that in turn may participate in progression of neurodegeneration. The mechanisms involved in…”
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Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes by Fuente-Martín, Esther, García-Cáceres, Cristina, Granado, Miriam, de Ceballos, María L, Sánchez-Garrido, Miguel Ángel, Sarman, Beatrix, Liu, Zhong-Wu, Dietrich, Marcelo O, Tena-Sempere, Manuel, Argente-Arizón, Pilar, Díaz, Francisca, Argente, Jesús, Horvath, Tamas L, Chowen, Julie A

“…Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy…”
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Sex Differences in Hypothalamic Changes and the Metabolic Response of TgAPP Mice to a High Fat Diet by Freire-Regatillo, Alejandra, Diaz-Pacheco, Sonia, Frago, Laura M., Arévalo, María-Ángeles, Argente, Jesús, Garcia-Segura, Luis M., de Ceballos, María L., Chowen, Julie A.

“…The propensity to develop neurodegenerative diseases is influenced by diverse factors including genetic background, sex, lifestyle, including dietary habits…”
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Vascular Dysfunction in a Transgenic Model of Alzheimer's Disease: Effects of CB1R and CB2R Cannabinoid Agonists by Navarro-Dorado, Jorge, Villalba, Nuria, Prieto, Dolores, Brera, Begoña, Martín-Moreno, Ana M, Tejerina, Teresa, de Ceballos, María L

“…There is evidence of altered vascular function, including cerebrovascular, in Alzheimer's disease (AD) and transgenic models of the disease. Indeed…”
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Preliminary research on 1-(4-bromo-2-nitroimidazol-1-yl)-3-[18F]fluoropropan-2-ol as a novel brain hypoxia PET tracer in a rodent model of stroke by Nieto, Elena, Delgado, Mercedes, Sobrado, Mónica, de Ceballos, María L., Alajarín, Ramón, García-García, Luis, Kelly, James, Lizasoain, Ignacio, Pozo, Miguel A., Álvarez-Builla, Julio

“…The synthesis of the new radiotracer precursor 4-Br-NITTP and the radiolabeling of the new tracer 1-(4-bromo-2-nitroimidazol-1-yl)-3-[18F]fluoropropan-2-ol…”
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Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by Gómez del Pulgar, Teresa, de Ceballos, Marı́a L., Guzmán, Manuel, Velasco, Guillermo

“…Cannabinoids, the active components of marijuana and their endogenous counterparts, exert many of their actions on the central nervous system by binding to the…”
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Functional responses to the cannabinoid agonist WIN 55,212-2 in neonatal rats of both genders: influence of weaning by Borcel, Erika, Pérez-Alvarez, Laura, de Ceballos, Marı́a L, Ramirez, Belén G, Marco, Eva M a, Fernández, Beatriz, Rubio, Marina, Guaza, Carmen, Viveros, M a-Paz

“…We have studied behavioural, biochemical and endocrine responses to the cannabinoid agonist WIN 55,212-2 (WIN) in neonatal rats, as well as the effects of…”
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The AMP‐Activated Protein Kinase Is Involved in the Regulation of Ketone Body Production by Astrocytes by Blázquez, Cristina, Woods, Angela, De Ceballos, María L, Carling, David, Guzmán, Manuel

“…: The possible role of the AMP‐activated protein kinase (AMPK), a highly conserved stress‐activated kinase, in the regulation of ketone body production by…”
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High-fat diet alters stress behavior, inflammatory parameters and gut microbiota in Tg APP mice in a sex-specific manner by Yanguas-Casás, Natalia, Torres-Fuentes, Cristina, Crespo-Castrillo, Andrea, Diaz-Pacheco, Sonia, Healy, Kiera, Stanton, Catherine, Chowen, Julie A., Garcia-Segura, Luis M., Arevalo, Maria Angeles, Cryan, John F., de Ceballos, Maria L.

“…Long-term high-fat diet (HFD) consumption commonly leads to obesity, a major health concern of western societies and a risk factor for Alzheimer's disease…”
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Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: modulation of uptake as a survival mechanism by Fernández-Tomé, Paz, Brera, Begoña, Arévalo, María-Angeles, de Ceballos, María L

“…Glutamate transporters are vulnerable to oxidants resulting in reduced uptake function. We have studied the effects of beta-amyloid(25-35) (beta A(25-35)) on…”
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Amyloid-β1-40 differentially stimulates proliferation, activation of oxidative stress and inflammatory responses in male and female hippocampal astrocyte cultures by Lennol, Matthew P., Canelles, Sandra, Guerra-Cantera, Santiago, Argente, Jesús, García-Segura, Luis Miguel, de Ceballos, María L., Chowen, Julie A., Frago, Laura M.

“…Diagram representing the effects of Aβ 1-40 on astrocytes. Aβ 1-40 on male astrocytes increased survival and decreased cell death compared to female…”
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Impaired hippocampal glucoregulation in the cannabinoid CB1 receptor knockout mice as revealed by an optimized in vitro experimental approach by Lemos, Cristina, Valério-Fernandes, Ângela, Ghisleni, Gabriele C., Ferreira, Samira G., Ledent, Catherine, de Ceballos, María L., Köfalvi, Attila

“…► We optimized a protocol to follow glucose uptake and metabolism in vitro. ► This method employs two types of radioactive glucose analogues. ► Deoxyglucose is…”
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Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease by Köfalvi, Attila, Lemos, Cristina, Martín-Moreno, Ana M., Pinheiro, Bárbara S., García-García, Luis, Pozo, Miguel A., Valério-Fernandes, Ângela, Beleza, Rui O., Agostinho, Paula, Rodrigues, Ricardo J., Pasquaré, Susana J., Cunha, Rodrigo A., de Ceballos, María L.

“…Cannabinoid CB2 receptors (CB2Rs) are emerging as important therapeutic targets in brain disorders that typically involve neurometabolic alterations. We here…”
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