Search Results - "de Cavanagh, Elena M V"

Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition by de Cavanagh, Elena M V, Inserra, Felipe, Ferder, León

“…Caloric restriction (CR), renin angiotensin system blockade (RAS-bl), and rapamycin-mediated mechanistic target of rapamycin (mTOR) inhibition increase…”
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Mitochondrial function and nitric oxide metabolism are modified by enalapril treatment in rat kidney by Piotrkowski, Barbara, Fraga, Cesar G, de Cavanagh, Elena M V

“…The renal and cardiac benefits of renin-angiotensin system (RAS) inhibition in hypertension exceed those attributable to blood pressure reduction, and seem to…”
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Renin–angiotensin system inhibitors positively impact on multiple aging regulatory pathways: Could they be used to protect against human aging? by Cavanagh, Elena M. V., Inserra, Felipe, Ferder, León

“…The renin–angiotensin system (RAS)—a classical blood pressure regulator—largely contributes to healthy organ development and function. Besides, RAS activation…”
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Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint by de Cavanagh, Elena Mv, Ferder, Marcelo, Inserra, Felipe, Ferder, Leon

“…Malfunctioning mitochondria strongly participate in the pathogenesis of cardiovascular damage associated with hypertension and other disease conditions…”
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Renal mitochondrial dysfunction in spontaneously hypertensive rats is attenuated by losartan but not by amlodipine by de Cavanagh, Elena M V, Toblli, Jorge E, Ferder, León, Piotrkowski, Bárbara, Stella, Inés, Inserra, Felipe

“…Mitochondrial dysfunction is associated with cardiovascular damage; however, data on a possible association with kidney damage are scarce. Here, we aimed at…”
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Enalapril and losartan attenuate mitochondrial dysfunction in aged rats by De Cavanagh, Elena M. V., Piotrkowski, Barbara, Basso, Nidia, Stella, Ines, Inserra, Felipe, Ferder, Leon, Fraga, Cesar G.

“…ABSTRACT Renin‐angiotensin system (RAS) inhibition can attenuate the effects of aging on renal function and structure; however, its effect on mitochondrial…”
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Sympathetic predominance is associated with impaired endothelial progenitor cells and tunneling nanotubes in controlled-hypertensive patients by de Cavanagh, Elena M V, González, Sergio A, Inserra, Felipe, Forcada, Pedro, Castellaro, Carlos, Chiabaut-Svane, Jorge, Obregón, Sebastián, Casarini, María Jesús, Kempny, Pablo, Kotliar, Carol

“…Early endothelial progenitor cells (early EPC) and late EPC are involved in endothelial repair and can rescue damaged endothelial cells by transferring…”
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Vascular Structure and Oxidative Stress in Salt-Loaded Spontaneously Hypertensive Rats: Effects of Losartan and Atenolol by de Cavanagh, Elena M.V., Ferder, León F., Ferder, Marcelo D., Stella, Inés Y., Toblli, Jorge E., Inserra, Felipe

“…Background Renin–angiotensin system (RAS) modulation by high dietary sodium may contribute to salt-induced hypertension, oxidative stress, and target organ…”
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Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria? by de Cavanagh, Elena M V, Inserra, Felipe, Ferder, León

“…Protein and lipid oxidation-mainly by mitochondrial reactive oxygen species (mtROS)-was proposed as a crucial determinant of health and lifespan. Angiotensin…”
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Sodium Intake Is Associated With Parasympathetic Tone and Metabolic Parameters in Mild Hypertension by González, Sergio A., Forcada, Pedro, Cavanagh, Elena M.V. de, Inserra, Felipe, Svane, J. Chiabaut, Obregón, Sebastian, Castellaro, Carlos, Olano, Daniel, Hita, Alejandro, Kotliar, Carol V.

“…Background Although the impairment of parasympathetic cardiac control was described in hypertensives submitted to a high salt diet, the impact of this…”
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The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: a hypothesis including the participation of mitochondria in aging by de Cavanagh, Elena M V, Piotrkowski, Barbara, Fraga, Cesar G

“…The objective of improving health is intimately associated with preventing and delaying age-related diseases. Nutritional and pharmacological approaches aimed…”
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Local and Systemic Cellular Immunity in Early Renal Artery Atherosclerosis by Kotliar, Carol, Juncos, Luis, Inserra, Felipe, de Cavanagh, Elena M V, Chuluyan, Eduardo, Aquino, Jorge B, Hita, Alejandro, Navari, Carlos, Sánchez, Ramiro

“…Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression,…”
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Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients by de Cavanagh, Elena M. V., Honegger, Alba E., Hofer, Erica, Bordenave, Raul H., Bullorsky, Eduardo O., Chasseing, Norma A., Fraga, Cesar

“…BACKGROUND Bone marrow (BM) is an important tissue in the generation of immunocompetent and peripheral blood cells. The precursors of hematopoietic cells in BM…”
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Renin–angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content and gene expression by de Cavanagh, Elena M.V., Flores, Idhaliz, Ferder, Marcelo, Inserra, Felipe, Ferder, León

“…Chronic renin–angiotensin system inhibition protects against liver fibrosis, ameliorates age-associated mitochondrial dysfunction and increases rodent…”
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Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes by de Cavanagh, Elena M V, Ferder, León, Toblli, Jorge E, Piotrkowski, Bárbara, Stella, Inés, Fraga, Cesar G, Inserra, Felipe

“…To investigate whether ANG II type 1 (AT(1)) receptor blockade could protect kidney mitochondria in streptozotocin-induced Type 1 diabetes, we treated 8-wk-old…”
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Protective effect of the inhibition of the renin–angiotensin system on aging by Basso, Nidia, Paglia, Nora, Stella, Inés, de Cavanagh, Elena M.V., Ferder, León, del Rosario Lores Arnaiz, María, Inserra, Felipe

“…Experimental studies indicate that chronic long-term inhibition of the renin–angiotensin system (RAS) can prevent most of the deleterious effects due to aging…”
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Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues by de Cavanagh, E M, Inserra, F, Ferder, L, Fraga, C G

“…The effect of enalapril and captopril on total glutathione content (GSSG + GSH) and selenium-dependent glutathione peroxidase (Se-GPx) and glutathione…”
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Cardiac mitochondrial function and tissue remodelling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats by Piotrkowski, Barbara, Koch, Osvaldo R, De Cavanagh, Elena M V, Fraga, César G

“…Renal and cardiac benefits of renin-angiotensin system inhibition exceed blood pressure (BP) reduction and seem to involve mitochondrial function. It has been…”
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Enalapril Attenuates Oxidative Stress in Diabetic Rats by de Cavanagh, Elena M.V, Inserra, Felipe, Toblli, Jorge, Stella, Inés, Fraga, César G, Ferder, León

“…Oxidative stress is involved in both the pathogenesis and complications of diabetes. ACE inhibitors can slow the progression of cardiac and renal impairments…”
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Role of peroxidase inhibition by insulin in the bovine thyroid cell proliferation mechanism by Krawiec, León, Pizarro, Ramón A, Aphalo, Paula, de Cavanagh, Elena M. V., Pisarev, Mario A., Juvenal, Guillermo J., Policastro, Lucía, Bocanera, Laura V.

“…Monolayer primary cultures of thyroid cells produce, in the presence of insulin, a cytosolic inhibitor of thyroid peroxidase (TPO), lacto peroxidase (LPO),…”
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