Search Results - "de Castro, Joao Marcelo"

Antimalarials and macrolides: a review of off-label pharmacotherapies during the first wave of the SARS-CoV-2 pandemic by Ferreira, Paulo Michel Pinheiro, Sousa, Rayran Walter Ramos de, Dittz, Dalton, Sousa, João Marcelo de Castro e, Torres-Leal, Francisco Leonardo, Bezerra, Daniel Pereira

“…We critically analyzed clinical trials performed with chloroquine (CQ) and hydroxychloroquine (HCQ) with or without macrolides during the first wave of…”
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Protective Effect of Biflavones from Platonia insignis Mart. against Ethidium Bromide-Induced Lethality in Staphylococcus aureus by Moura, Andressa Sabrina Guimarães, Barreto, Júlia de Andrade Ferreira, Silva, Andressa Kelly Ferreira e, Nascimento, Maria Luísa Lima Barreto do, Pinheiro, Emanuelly Elanny Andrade, Moura, Arkellau Kenned Silva, Sousa, João Marcelo de Castro e, Lima-Neto, José de Souza, Citó, Antonia Maria das Graças Lopes, Coutinho, Henrique Douglas Melo, Barreto, Humberto Medeiros

“…Brazilian flora are highly diverse and have great potential for research into new medicines of plant origin. Platonia insignis Mart. is a fruit tree from the…”
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Advances in Antitumor Effects Using Liposomal Citrinin in Induced Breast Cancer Model by Moura, Michely Laiany Vieira, de Menezes, Ag-Anne Pereira Melo, de Oliveira Filho, José Williams Gomes, do Nascimento, Maria Luiza Lima Barreto, Dos Reis, Antonielly Campinho, Ribeiro, Alessandra Braga, da Silva, Felipe Cavalcanti Carneiro, Nunes, Adriana Maria Viana, Rolim, Hercília Maria Lins, de Carvalho Melo Cavalcante, Ana Amélia, Sousa, João Marcelo de Castro E

“…The study aimed to evaluate the antitumor and toxicogenetic effects of liposomal nanoformulations containing citrinin in animal breast carcinoma induced by…”
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Marinobufagin, a molecule from poisonous frogs, causes biochemical, morphological and cell cycle changes in human neoplasms and vegetal cells by Machado, Kátia da Conceição, Sousa, Lívia Queiroz de, Lima, Daisy Jereissati Barbosa, Soares, Bruno Marques, Cavalcanti, Bruno Coêlho, Maranhão, Sarah Sant'Anna, Noronha, Janaina da Costa de, Rodrigues, Domingos de Jesus, Militão, Gardenia Carmen Gadelha, Chaves, Mariana Helena, Vieira-Júnior, Gerardo Magela, Pessoa, Cláudia, Moraes, Manoel Odorico de, Sousa, João Marcelo de Castro e, Melo-Cavalcante, Ana Amélia de Carvalho, Ferreira, Paulo Michel Pinheiro

“…[Display omitted] •Marinobufagin has high antiproliferative activity on human tumor lines only.•HL-60 cells displayed binucleation, cellular and nuclear…”
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Toxicogenetic profile of the monoterpene alpha-terpineol on normal and tumor eukaryotic cells by Negreiros, Helber Alves, Fontele, Sabryna Brena Cunha, Batista, Felipe Alves, Farias, Marlene Gomes de, Silva, Felipe Cavalcanti Carneiro da, Nascimento, Maria Luisa Lima Barreto do, Moura, Kariely Gonçalves de, Correa, Layde de Sousa, Pereira, Ana Rafaela Silva, Lopes, Luana de Oliveira, Ferreira, Paulo Michel Pinheiro, Mendes, Anderson Nogueira, Gonçalves, Juan Carlos Ramos, Melo-Cavalcante, Ana Amélia de Carvalho, Sousa, João Marcelo de Castro e

“…Alpha-terpineol is a monoterpene alcohol found in essential oils from medicinal plants with some well-known pharmacological activities and widely used in…”
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Toxic profile of marinobufagin from poisonous Amazon toads and antitumoral effects on human colorectal carcinomas by Ferreira, Paulo Michel Pinheiro, Sousa, Lívia Queiroz de, Sousa, Rayran Walter Ramos de, Rodrigues, Domingos de Jesus, Monção Filho, Evaldo dos Santos, Chaves, Mariana Helena, Vieira Júnior, Gerardo Magela, Rizzo, Márcia dos Santos, Filgueiras, Lívia Alves, Mendes, Anderson Nogueira, Lima, Daisy Jereissati Barbosa, Pessoa, Cláudia, Sousa, João Marcelo de Castro e, Rodrigues, Ana Carolina Borges da Cruz, Soares, Milena Botelho Pereira, Bezerra, Daniel Pereira

“…South Americans natives have extensively used the toad “kururu” to reduce/treat skin infections, cutaneous lesions and sores. They release secretions rich in…”
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Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta-analysis of preclinical studies by dos Reis Oliveira, Camila, Pereira, Joedna Cavalcante, Barros Ibiapina, Andressa, Roseno Martins, Italo Rossi, de Castro e Sousa, João Marcelo, Ferreira, Paulo Michel Pinheiro, Carneiro da Silva, Felipe Cavalcanti

“…Buthionine sulfoximine (BSO) is a synthetic amino acid that blocks the biosynthesis of reduced glutathione (GSH), an endogenous antioxidant cellular component…”
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Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer by Islam, Muhammad Torequl, Ali, Eunüs S., Uddin, Shaikh Jamal, Islam, Md. Amirul, Shaw, Subrata, Khan, Ishaq N., Saravi, Seyed Soheil Saeedi, Ahmad, Saheem, Rehman, Shahnawaz, Gupta, Vijai Kumar, Găman, Mihnea-Alexandru, Găman, Amelia Maria, Yele, Santosh, Das, Asish Kumar, de Castro e Sousa, João Marcelo, de Moura Dantas, Sandra Maria Mendes, Rolim, Hercília Maria Lins, de Carvalho Melo-Cavalcante, Ana Amélia, Mubarak, Mohammad S., Yarla, Nagendra Sastry, Shilpi, Jamil A., Mishra, Siddhartha Kumar, Atanasov, Atanas G., Kamal, Mohammad Amjad

“…The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been proven to possess several important protective biological activities,…”
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α-tocopherol as a selective modulator of toxicogenic damage induced by antineoplastic agents cyclophosphamide and doxorubicin by de Oliveira, Victor Alves, Monteiro Fernandes, Andressa Naiane Rodrigues, dos Santos Leal, Lauana Maria, Ferreira Lima, Paloma Alves, Silva Pereira, Ana Rafaela, Pereira, Irislene Costa, Negreiros, Helber Alves, Pereira-Freire, Joilane Alves, da Silva, Felipe Cavalcanti Carneiro, de Carvalho Melo Cavalcante, Ana Amélia, Torres-Leal, Francisco Leonardo, de Azevedo Paiva, Adriana, de Castro e Sousa, João Marcelo

“…The aim of this study was to determine the oxidative/antioxidative effects, modulatory and selective potential of α-tocopherol (vitamin E) on antineoplastic…”
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Mycotoxin‐assisted mitochondrial dysfunction and cytotoxicity: Unexploited tools against proliferative disorders by Islam, Muhammad Torequl, Mishra, Siddhartha Kumar, Tripathi, Swati, Alencar, Marcus Vinícius Oliveira Barros, e Sousa, João Marcelo de Castro, Rolim, Hercília Maria Lins, de Medeiros, Maria das Graças Freire, Ferreira, Paulo Michel Pinheiro, Rouf, Razina, Uddin, Shaikh Jamal, Mubarak, Mohammad Suleiman, Melo‐Cavalcante, Ana Amélia de Carvalho

“…Mitochondria are the powerhouse of cells, which upon dysfunctions may lead to several diseases. Mycotoxins are the toxic secondary metabolites from fungi which…”
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Comprehensive preclinical studies on the bioactivity of Orbignya phalerata Mart. (Babassu) and its derived products: a systematic review by Debia, Nicole, Castro, Isione Oliveira, Sousa, Ana Beatriz Santana, de Oliveira, Victor Alves, Negreiros, Helber Alves, Ferreira, Paulo Michel Pinheiro, de Castro e Sousa, João Marcelo

“…Background Babassu ( Orbignya phalerata Mart.) is a palm tree well distributed in Latin America, whose fruit has a mesocarp and kernel used for human feeding,…”
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Assessment of Grape, Plum and Orange Synthetic Food Flavourings Using in vivo Acute Toxicity Tests by Sales, Ila Monize Sousa, Barbosa, Janaína Sousa, Silva Dos Santos, Fabelina Karollyne, Carneiro da Silva, Felipe Cavalcanti, Ferreira, Paulo Michel Pinheiro, Marcelo de Castro E Sousa, João, Peron, Ana Paula

“…The present study evaluates the acute toxicity of synthetic grape, plum and orange flavourings in root meristem cells of at the doses of 3.5, 7.0 and 14.0…”
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Retinol palmitate against toxicogenic damages of antineoplastic drugs on normal and tumor cells by de Carvalho, Ricardo Melo, de Alencar, Marcus Vinicius Oliveira Barros, da Mata, Ana Maria Oliveira Ferreira, de Lima, Rosália Maria Tôrres, Sousa de Aguiar, Rai Pablo, Silva Teixeira, Jadson, Correia Jardim Paz, Márcia Fernanda, Morais Chaves, Soane Kaline, Islam, Muhammad Torequl, Sousa, João Marcelo de Castro e, Pinheiro Ferreira, Paulo Michel, Melo Cavalcante, Ana Amélia de Carvalho, Salehi, Bahare, Setzer, William N., Sharifi-Rad, Javad

“…The lack of tissue selectivity of anticancer drugs generates intense collateral and adverse effects of cancer patients, making the incorporation of vitamins or…”
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Pharmacological and physicochemical profile of arylacetamides as tools against human cancers by Ferreira, Paulo Michel Pinheiro, Machado, Kátia da Conceição, Lavorato, Stefânia Neiva, Oliveira, Fátima de Cássia Evangelista de, Silva, Jurandy do Nascimento, Almeida, Antonia Amanda Cardoso de, Santos, Luciano de Souza, Silva, Valdenizia Rodrigues, Bezerra, Daniel Pereira, Soares, Milena Botelho Pereira, Pessoa, Cláudia, Moraes Filho, Manoel Odorico de, Ferreira, José Roberto de Oliveira, Sousa, João Marcelo de Castro e, Maltarollo, Vinícius Gonçalves, Alves, Ricardo José

“…Arylacetamides are widely used as synthetic intermediates to obtain medicinal substances. This work evaluated in vitro antiproliferative activity of ten…”
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Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review by de Sousa Coelho, Maria do Perpetuo Socorro, Pereira, Irislene Costa, de Oliveira, Kynnara Gabriella Feitosa, Oliveira, Iara Katryne Fonseca, dos Santos Rizzo, Márcia, de Oliveira, Victor Alves, Carneiro da Silva, Felipe Cavalcanti, Torres-Leal, Francisco Leonardo, de Castro e Sousa, João Marcelo

“…Vitamin E has been investigated for its antitumor potential, including the ability to change cancer gene pathways as well as promote antioxidant and…”
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In vivo antigenotoxic and anticlastogenic effects of fresh and processed cashew (Anacardium occidentale) apple juices by Melo-Cavalcante, Ana Amélia de Carvalho, Dantas, Sandra Maria Mendes de Moura, Leite, Aracelli de Sousa, Matos, Leomá Albuquerque, e Sousa, João Marcelo de Castro, Picada, Jaqueline Nascimento, da Silva, Juliana

“…Cashew apple juice and cajuina (processed juice) are drinks widely consumed in northeast Brazil. In vitro studies have shown that both juices have…”
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Association between matrix metalloproteinase-9 gene polymorphism and breast cancer in Brazilian women by Oliveira, Victor Alves de, Chagas, Diego Cipriano, Amorim, Jefferson Rodrigues, Pereira, Renato de Oliveira, Nogueira, Thais Alves, Borges, Victória Maria Luz, Campos-Verde, Larysse Maira, Martins, Luana Mota, Rodrigues, Gilmara Peres, Nery, Elmo de Jesus, Sampaio, Fabiane Araújo, Lopes-Costa, Pedro Vitor, Sousa, João Marcelo de Castro e, Silva, Vladmir Costa, Silva, Felipe Cavalcanti Carneiro da, Silva, Benedito Borges da

“…This study aimed to determine the relationship between rs17576 (MMP-9) polymorphism and increased cancer risk in a Brazilian breast cancer cohort. This study…”
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Toxicity at the cellular level of artificial synthetic flavorings by Sales, Ila Monize Sousa, Oliveira, Jussara Damascena de, Santos, Fabelina Karollyne Silva dos, Feitoza, Lidiane De Lima, Sousa, João Marcelo de Castro e, Peron, Ana Paula

“… The goal of the present study was to evaluate the cytotoxicity and genotoxicity of artificial synthetic flavoring agents cookie and tutti-frutti. To this end,…”
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Allium cepa as a Toxicogenetic Investigational Tool for Plant Extracts: A Systematic Review by de Melo, Erisson Cruz, da Silva Pinheiro, Randyson, Costa, Bruno Sousa, de Lima, Rosália Maria Tôrres, Soares Dias, Ana Carolina, Dos Santos, Teresinha de Jesus Aguiar, do Nascimento, Maria Luisa Lima Barreto, de Castro E Sousa, João Marcelo, Islam, Muhammad Torequl, Cavalcante, Ana Amélia de Carvalho Melo, El-Nashar, Heba A S, El-Shazly, Mohamed, de Oliveira Filho, José Williams Gomes

“…Toxicological studies are important to investigate the genotoxic effects of various substances. Allium cepa can be used as test model for this purpose. This…”
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Laboratory and physiological aspects of substitute metazoan models for in vivo pharmacotoxicological analysis by Ferreira, Paulo Michel Pinheiro, Ramos, Carla Lorena Silva, Filho, José Ivo Araújo Beserra, Conceição, Micaely Lorrana Pereira, Almeida, Mateus Lima, do Nascimento Rodrigues, Débora Caroline, Porto, Jhonatas Cley Santos, de Castro E Sousa, João Marcelo, Peron, Ana Paula

“…New methods are essential to characterize the performance of substitute procedures for detecting therapeutic action(s) of a chemical or key signal of…”
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