Search Results - "de Castro, Alexandre A"

Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments by Sales, Thais A, Prandi, Ingrid G, Castro, Alexandre A de, Leal, Daniel H S, Cunha, Elaine F F da, Kuca, Kamil, Ramalho, Teodorico C

“…The brain has a unique biological complexity and is responsible for important functions in the human body, such as the command of cognitive and motor…”
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Computational evidence for nitro derivatives of quinoline and quinoline N-oxide as low-cost alternative for the treatment of SARS-CoV-2 infection by Assis, Letícia C., de Castro, Alexandre A., de Jesus, João P. A., Nepovimova, Eugenie, Kuca, Kamil, Ramalho, Teodorico C., La Porta, Felipe A.

“…A new and more aggressive strain of coronavirus, known as SARS-CoV-2, which is highly contagious, has rapidly spread across the planet within a short period of…”
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Computational Enzymology and Organophosphorus Degrading Enzymes: Promising Approaches Toward Remediation Technologies of Warfare Agents and Pesticides by Ramalho, Teodorico C, de Castro, Alexandre A, Silva, Daniela R, Silva, Maria Cristina, Franca, Tanos C C, Bennion, Brian J, Kuca, Kamil

“…The re-emergence of chemical weapons as a global threat in hands of terrorist groups, together with an increasing number of pesticides intoxications and…”
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Silver(I) and Copper(II) 1,10-phenanthroline-5,6-dione complexes as promising antivirulence strategy against 'Leishmania': Focus on Gp63 (Leishmanolysin) by Oliveira, Simone S C, Correia, Claudyane A, Santos, Vanessa S, da Cunha, Elaine F F, de Castro, Alexandre A, Ramalho, Teodorico C, Devereux, Michael, McCann, Malachy, Branquinha, Marta H, Santos, André L S

“…Leishmaniasis, caused by protozoa of the genus 'Leishmania', encompasses a group of neglected diseases with diverse clinical and epidemiological manifestations…”
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Molecular Docking, Metal Substitution and Hydrolysis Reaction of Chiral Substrates of Phosphotriesterase by de Castro, Alexandre A, Caetano, Melissa S, Silva, Telles C, Mancini, Daiana T, Rocha, Eduardo Pereira, da Cunha, Elaine F F, Ramalho, Teodorico C

“…During World War II, organophosphorus compounds with neurotoxic action were developed and used as the basis for the development of structures currently used as…”
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Assessing the Therapeutic and Toxicological Profile of Novel Acetylcholinesterase Reactivators: Value of In Silico And In Vitro Data by Ramalho, Teodorico C, de Castro, Alexandre A, Leal, Daniel H S, Teixeira, Jessika P, da Cunha, Elaine F F, Kuca, Kamil

“…Organophosphorus compounds (OP) make up an important class of inhibitors, mostly employed as pesticides, even as chemical weapons. These toxic substances act…”
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Identification of biotransformation products of disperse dyes with rat liver microsomes by LC-MS/MS and theoretical studies with DNA: Structure-mutagenicity relationship using Salmonella/microsome assay by Franco, Jefferson Honorio, Silva, Bianca F. da, Oliveira, Regina V., Meireles, Gabriela, de Oliveira, Danielle Palma, Castro, Alexandre A. de, Ramalho, Teodorico C., Zanoni, Maria V.B.

“…Azo dyes are known as a group of substances with DNA damage potential that depend on the nature and number of azo groups connected to aromatic rings (benzene…”
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Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target by Galdino, Anna Clara M, Viganor, Lívia, de Castro, Alexandre A, da Cunha, Elaine F F, Mello, Thaís P, Mattos, Larissa M, Pereira, Marcos D, Hunt, Mary C, O'Shaughnessy, Megan, Howe, Orla, Devereux, Michael, McCann, Malachy, Ramalho, Teodorico C, Branquinha, Marta H, Santos, André L S

“…Elastase B (lasB) is a multifunctional metalloenzyme secreted by the gram-negative pathogen , and this enzyme orchestrates several physiopathological events…”
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A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase by Kuca, Kamil, Musilek, Kamil, Jun, Daniel, Zdarova-Karasova, Jana, Nepovimova, Eugenie, Soukup, Ondrej, Hrabinova, Martina, Mikler, John, Franca, Tanos C C, Da Cunha, Elaine F F, De Castro, Alexandre A, Valis, Martin, Ramalho, Teodorico C

“…Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the…”
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Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication by Soares, Flávia V, de Castro, Alexandre A, Pereira, Ander F, Leal, Daniel H S, Mancini, Daiana T, Krejcar, Ondrej, Ramalho, Teodorico C, da Cunha, Elaine F F, Kuca, Kamil

“…Organophosphorus compounds (OP) are part of a group of compounds that may be hazardous to health. They are called neurotoxic agents because of their action on…”
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Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects by de Castro, Alexandre, Polisel, Daniel, Pereira, Bruna, da Cunha, Elaine, Kuca, Kamil, Nepovimova, Eugenie, Ramalho, Teodorico

“…Organophosphorus (OP) compounds are used as both chemical weapons and pesticides. However, these agents are very dangerous and toxic to humans, animals, and…”
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Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019) by de Castro, Alexandre A, Assis, Letícia C, Soares, Flávia V, Kuca, Kamil, Polisel, Daniel A, da Cunha, Elaine F F, Ramalho, Teodorico C

“…Acetylcholinesterase (AChE) is the key enzyme responsible for deactivating the ACh neurotransmitter. Irreversible or prolonged inhibition of AChE, therefore,…”
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Future Therapeutic Perspectives into the Alzheimer's Disease Targeting the Oxidative Stress Hypothesis by Teixeira, Jéssika P, de Castro, Alexandre A, Soares, Flávia V, da Cunha, Elaine F F, Ramalho, Teodorico C

“…Alzheimer's disease (AD) is a neurodegenerative disease that is usually accompanied by aging, increasingly being the most common cause of dementia in the…”
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Computational enzymology for degradation of chemical warfare agents: promising technologies for remediation processes by de Castro, Alexandre A, Assis, Letícia C, Silva, Daniela R, Corrêa, Silviana, Assis, Tamiris M, Gajo, Giovanna C, Soares, Flávia V, Ramalho, Teodorico C

“…Chemical weapons are a major worldwide problem, since they are inexpensive, easy to produce on a large scale and difficult to detect and control. Among the…”
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Combining computational tools and experimental studies towards endocrine disruptors mitigation: A review of biocatalytic and adsorptive processes by Silva, Maria Cristina, de Castro, Alexandre A., Lopes, Karla Lara, Ferreira, Igor F. Lara, Bretz, Raphael Resende, Ramalho, Teodorico C.

“…The endocrine disruptors (EDCs) are an important group of emerging contaminants, and their mitigation has been a huge challenge due to their chemistry…”
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Influence of auxochrome group in disperse dyes bearing azo groups as chromophore center in the biotransformation and molecular docking prediction by reductase enzyme: Implications and assessment for environmental toxicity of xenobiotics by Franco, Jefferson Honorio, da Silva, Bianca F., Dias, Elisangela Franciscon G., de Castro, Alexandre A., Ramalho, Teodorico C., Zanoni, Maria Valnice Boldrin

“…Synthetic azo dyes have increasingly become a matter of great concern as a result of the genotoxic and mutagenic potential of the products derived from azo dye…”
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Development of technologies applied to the biodegradation of warfare nerve agents: Theoretical evidence for asymmetric homogeneous catalysis by Pereira, Ander Francisco, de Castro, Alexandre A., Soares, Flavia Villela, Soares Leal, Daniel Henriques, da Cunha, Elaine F.F., Mancini, Daiana Teixeira, Ramalho, Teodorico C.

“…Organophosphorus compounds have been widely employed to the development of warfare nerve agents and pesticides, resulting in a huge number of people…”
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Experimental and theoretical affinity and catalysis studies between halogenated phenols and peroxidases: Understanding the bioremediation potential by Bretz, Raphael Resende, de Castro, Alexandre A., Lara Ferreira, Igor F., Ramalho, Teodorico C., Silva, Maria Cristina

“…Halogenated phenols, such as 2,4-dichlorophenol (2,4-DCP) and 4-bromophenol (4-BP) are pollutants generated by a various industrial sectors like chemical, dye,…”
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Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects by Polisel, Daniel A., de Castro, Alexandre A., Mancini, Daiana T., da Cunha, Elaine F.F., França, Tanos C.C., Ramalho, Teodorico C., Kuca, Kamil

“…Studies with oximes have been extensively developed to design new reactivators with better efficiency, and greater spectrum of action. In this study, we aimed…”
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Biotransformation of disperse dyes using nitroreductase immobilized on magnetic particles modified with tosyl group: Identification of products by LC-MS-MS and theoretical studies conducted with DNA by Franco, Jefferson Honorio, da Silva, Bianca F., de Castro, Alexandre A., Ramalho, Teodorico C., Pividori, María Isabel, Zanoni, Maria Valnice Boldrin

“…The present work evaluates the action of nitroreductase enzyme immobilized on Tosylactivated magnetic particles (MP-Tosyl) on three disperse dyes which contain…”
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