Effects of low-intensity non-coherent light therapy on the inflammatory process in the calcaneal tendon of ovariectomized rats

Effects of low-intensity non-coherent light therapy on the inflammatory process in the calcaneal tendon of ovariectomized rats

The aim of this experimental study was to investigate the effects of low-intensity light-emitting diode (LED) phototherapy on the inflammatory process in the calcaneal tendon of ovariectomized rats (OVX) through the involvement of the inflammatory mediators interleukin (IL)-6, IL-10, and tumor necro...

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Published in:Lasers in medical science Vol. 31; no. 1; pp. 33 - 40
Main Authors: Helrigle, Carla, de Carvalho, Paulo deTarso Camilo, Casalechi, Heliodora Leão, Leal-Junior, Ernesto Cesar Pinto, Fernandes, Guilherme Henrique Cardoso, Helrigel, Panmera Almeida, Rabelo, Rogério Leão, de Oliveira Aleixo-Junior, Ivo, Aimbire, Flavio, Albertini, Regiane
Format: Journal Article
Language:English
Published: London Springer London 01-01-2016
Springer Nature B.V
Subjects:
Achilles Tendon - injuries
Achilles Tendon - metabolism
Achilles Tendon - radiation effects
Animals
Cytokines - metabolism
Dentistry
ELISA
Female
Inflammation
Inflammation - metabolism
Inflammation - therapy
Injuries
Lasers
Light emitting diodes
Low-Level Light Therapy
Medical science
Medical treatment
Medicine
Medicine & Public Health
Optical Devices
Optics
Original Article
Ovariectomy
Photonics
Quantum Optics
Rats
Rats, Wistar
Rodents
Sampling
Tendons
Low-intensity LED
Photobiomodulation therapy
Inflammation
Ovariectomy
Calcaneal tendon injury
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Summary:The aim of this experimental study was to investigate the effects of low-intensity light-emitting diode (LED) phototherapy on the inflammatory process in the calcaneal tendon of ovariectomized rats (OVX) through the involvement of the inflammatory mediators interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-α). Thirty-five female Wistar rats were divided into 4 groups: 3 groups of OVX rats totaling 30 rats (untreated OVX rats [OVX injury group], treated OVX rats [OVX LED group], and control OVX rats; subgroups existed based on the sampling times, which were 3, 7, and 14 days) and 1 group of non-OVX rats (not OVX; n  = 5). Tendon injury was induced by trauma using a 208-g mass placed at 20 cm from the right tendon of each animal with energy of 0.70 J. The animals were treated 12 h after tendonitis with LED therapy and every 48 h thereafter until euthanasia (at 3, 7, or 14 days). The tendons were dissected and stored in liquid nitrogen at −196 °C, thawed only at the time of immunoenzymatic testing (ELISA). Groups treated with LED showed a decrease in the number of pro-inflammatory cells, IL-6, and TNF-α (p <0.05), and an increase in IL-10 ( p  < 0.05) when compared to the not OVX group ( p  < 0.05). It was concluded that low-intensity LED treatment using the parameters and wavelength of 945 nm in the time periods studied reduced the release of IL-6 and TNF-α and increased the release of IL-10, thereby improving the inflammatory response in OVX rats.
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ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-015-1821-7