Search Results - "de Carvalho, Ana"
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Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy
Published in Molecules (Basel, Switzerland) (20-02-2024)“…Cervical cancer was considered the fourth most common cancer worldwide in 2020. In order to reduce mortality, an early diagnosis of the tumor is required…”
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Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer
Published in Journal of medicinal chemistry (25-04-2024)“…Cisplatin (cDDP) resistance is a matter of concern in triple-negative breast cancer therapeutics. We measured the metabolic response of cDDP-sensitive (S) and…”
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3
A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line
Published in Molecules (Basel, Switzerland) (01-02-2023)“…A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt Put (NH ) ]Cl ) was synthesized and assessed as to its potential anticancer…”
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Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics
Published in International journal of molecular sciences (09-11-2022)“…Cisplatin (cDDP)-based chemotherapy is often limited by severe deleterious effects (nephrotoxicity, hepatotoxicity and neurotoxicity). The polynuclear…”
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5
A New Look into the Mode of Action of Metal-Based Anticancer Drugs
Published in Molecules (Basel, Switzerland) (07-01-2020)“…The mode of action of Pt- and Pd-based anticancer agents (cisplatin and Pd Spm) was studied by characterising their impact on DNA. Changes in conformation and…”
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Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vibrational Microspectroscopies
Published in International journal of molecular sciences (01-02-2023)“…Regarding the development of new antineoplastic agents, with a view to assess the selective antitumoral potential which aims at causing irreversible damage to…”
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Chemotherapeutic Targets in Osteosarcoma: Insights from Synchrotron-MicroFTIR and Quasi-Elastic Neutron Scattering
Published in The journal of physical chemistry. B (15-08-2019)“…This study aimed at the development of improved drugs against human osteosarcoma, which is the most common primary bone tumor in children and teenagers with a…”
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Response of Osteosarcoma Cell Metabolism to Platinum and Palladium Chelates as Potential New Drugs
Published in Molecules (Basel, Switzerland) (08-08-2021)“…This paper reports the first metabolomics study of the impact of new chelates Pt Spm and Pd Spm (Spm = Spermine) on human osteosarcoma cellular metabolism,…”
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Exploring Whole Cells of Rhizopus oryzae for Efficient Synthesis of Emollient Esters: Bioesters for Cosmetics
Published in Journal of the Brazilian Chemical Society (2024)“…Production of esters, organic compounds with emollient, emulsifying, and aromatic properties is growing due to high demand and their applications in the…”
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10
Stress-induced differential gene expression in cardiac tissue
Published in Scientific reports (28-04-2021)“…The stress response is adaptive and aims to guarantee survival. However, the persistence of a stressor can culminate in pathology. Catecholamines released as…”
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Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress
Published in Cellular and molecular neurobiology (2018)“…In the heart, catecholamine effects occur by activation of beta-adrenergic receptors (β-ARs), mainly the beta 1 (β 1 -AR) and beta 2 (β 2 -AR) subtypes, both…”
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Glycogen synthase kinase 3 induces multilineage maturation of human pluripotent stem cell-derived lung progenitors in 3D culture
Published in Development (Cambridge) (15-01-2019)“…Although strategies for directed differentiation of human pluripotent stem cells (hPSCs) into lung and airway have been established, terminal maturation of the…”
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Investigating Antibody Reactivity to the Intestinal Microbiome in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Feasibility Study
Published in International journal of molecular sciences (01-10-2023)“…Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic disease of unknown aetiology that is characterised by disabling chronic fatigue…”
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Vibrational microspectroscopy as a tool to unveil new chemotherapeutic strategies against osteosarcoma
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (05-09-2024)“…[Display omitted] •Drug combination administration had an enhanced cytotoxic effect compared to single drug.•Z-DNA conformation occurred mostly in polynuclear…”
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A systematic review on the neuroprotective perspectives of beta‐caryophyllene
Published in Phytotherapy research (01-12-2018)“…Beta (β)‐caryophyllene (BCAR) is a major sesquiterpene of various plant essential oils reported for several important pharmacological activities, including…”
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Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells
Published in International journal of molecular sciences (16-12-2023)“…This work investigated the mechanisms of action of conventional drugs, cisplatin and oxaliplatin, and the potentially less deleterious drug Pd Spermine (Spm)…”
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The psychoactive effects of Bryophyllum pinnatum (Lam.) Oken leaves in young zebrafish
Published in PloS one (01-01-2022)“…Bryophyllum pinnatum (Lam.) Oken (BP) is a plant that is used worldwide to treat inflammation, infections, anxiety, restlessness, and sleep disorders. While it…”
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Circulating osteogenic proteins are associated with coronary artery calcification and increase after myocardial infarction
Published in PloS one (23-08-2018)“…Coronary artery calcification (CAC) and atherosclerotic inflammation associate with increased risk of myocardial infarction (MI). Vascular calcification is…”
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Low skeletal muscle radiodensity is the best predictor for short-term major surgical complications in gastrointestinal surgical cancer: A cohort study
Published in PloS one (19-02-2021)“…The aim of this study was to evaluate whether body composition, muscle function, and their association are predictive factors for short-term postoperative…”
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Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model
Published in International journal of molecular sciences (01-10-2021)“…The interest in palladium(II) compounds as potential new anticancer drugs has increased in recent years, due to their high toxicity and acquired resistance to…”
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