Histopathological and Immunohistochemical Characteristics of Thyroid Carcinoma in the Dog

Thyroid carcinomas are a common form of endocrine neoplasia in dogs. In the present study, we combined histopathology with immunohistochemistry (IHC) to search for the presence of oestrogen receptor alpha (ORα), Cox-2 and Ki67 in canine thyroid carcinomas. Forty-eight thyroid carcinomas were diagnos...

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Bibliographic Details
Published in:	Journal of comparative pathology Vol. 177; pp. 34 - 41
Main Authors:	Soares, L.M.C., Pereira, A.H.B., de Campos, C.G., Rocha, L.S., dos Santos, T.Á., Souza, M.A., Jark, P.C., Pescador, C.A.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-05-2020
Subjects:	Adenocarcinoma, Follicular - pathology Adenocarcinoma, Follicular - veterinary Animals Biomarkers, Tumor - metabolism Calcitonin - metabolism Carcinoma, Neuroendocrine - pathology Carcinoma, Neuroendocrine - veterinary Diagnosis, Differential dog Dog Diseases Dogs Endocrine Gland Neoplasms - veterinary immunohistochemistry Immunohistochemistry - veterinary Thyroglobulin - metabolism thyroid carcinoma Thyroid Neoplasms - pathology Thyroid Neoplasms - veterinary dog thyroid carcinoma immunohistochemistry
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Summary:	Thyroid carcinomas are a common form of endocrine neoplasia in dogs. In the present study, we combined histopathology with immunohistochemistry (IHC) to search for the presence of oestrogen receptor alpha (ORα), Cox-2 and Ki67 in canine thyroid carcinomas. Forty-eight thyroid carcinomas were diagnosed throughout the study period. Thyroglobulin and calcitonin IHC distinguished between thyroid tumours with a follicular and medullary (C-cell) origin, respectively. IHC-based diagnosis showed that 42 (87.50%) of the cases were follicular cell carcinoma. In these cases, the follicular–compact pattern was the most frequent (n = 20/42; 47.62%) and six cases (12.5%) were medullary cell (C-cell) carcinomas. Both medullary (C-cell) and follicular carcinomas expressed Ki67 and Cox-2. No differences were observed between medullary and follicular carcinomas with respect to expression of Ki67 (P = 0.34) and Cox-2 (P = 0.9523) markers. A total of 4.17% (n = 2/48) of thyroid carcinomas showed positive nuclear labelling for ORα, suggesting that oestrogen does not directly participate in the pathogenesis of canine thyroid neoplasia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-9975 1532-3129
DOI:	10.1016/j.jcpa.2020.04.002