Search Results - "de Caluwé, Alex"

Immunotherapy in breast cancer: an overview of current strategies and perspectives by Debien, Véronique, De Caluwé, Alex, Wang, Xiaoxiao, Piccart-Gebhart, Martine, Tuohy, Vincent K., Romano, Emanuela, Buisseret, Laurence

“…Recent progress in immunobiology has led the way to successful host immunity enhancement against breast cancer. In triple-negative breast cancer, the…”
Get full text

PRIMMO study protocol: a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer by Tuyaerts, Sandra, Van Nuffel, An M T, Naert, Eline, Van Dam, Peter A, Vuylsteke, Peter, De Caluwé, Alex, Aspeslagh, Sandrine, Dirix, Piet, Lippens, Lien, De Jaeghere, Emiel, Amant, Frédéric, Vandecasteele, Katrien, Denys, Hannelore

“…Immunotherapeutic approaches have revolutionized oncological practice but are less evaluated in gynecological malignancies. PD-1/PD-L1 blockade in…”
Get full text

Neo-CheckRay: radiation therapy and adenosine pathway blockade to increase benefit of immuno-chemotherapy in early stage luminal B breast cancer, a randomized phase II trial by De Caluwé, Alex, Buisseret, Laurence, Poortmans, Philip, Van Gestel, Dirk, Salgado, Roberto, Sotiriou, Christos, Larsimont, Denis, Paesmans, Marianne, Craciun, Ligia, Stylianos, Drisis, Vandekerckhove, Christophe, Reyal, Fabien, Isabelle, Veys, Eiger, Daniel, Piccart, Martine, Romano, Emanuela, Ignatiadis, Michail

“…Residual breast cancer after neo-adjuvant chemotherapy (NACT) predicts disease outcome and is a surrogate for survival in aggressive breast cancer (BC)…”
Get full text

Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers by Machiels, Melanie, Oulkadi, Redouane, Tramm, Trine, Stecklein, Shane R., Somaiah, Navita, De Caluwé, Alex, Klein, Jonathan, Tran, William T., Salgado, Roberto

“…Radiation therapy (RT) has long been fundamental for the curative treatment of breast cancer. While substantial progress has been made in the anatomical and…”
Get full text

Delineation guidelines for the lymphatic target volumes in ‘prone crawl’ radiotherapy treatment position for breast cancer patients by Stouthandel, Michael E. J., Kayser, Françoise, Vakaet, Vincent, Khoury, Ralph, Deseyne, Pieter, Monten, Chris, Schoepen, Max, Remouchamps, Vincent, De Caluwé, Alex, Janoray, Guillaume, De Neve, Wilfried, Mazy, Stephane, Veldeman, Liv, Van Hoof, Tom

“…Our recently developed prone crawl position (PCP) for radiotherapy of breast cancer patients with lymphatic involvement showed promising preliminary data and…”
Get full text

Split-VMAT technique to control the deep inspiration breath hold time for breast cancer radiotherapy by Poeta, Sara, Jourani, Younes, De Caluwé, Alex, Van den Begin, Robbe, Van Gestel, Dirk, Reynaert, Nick

“…To improve split-VMAT technique by optimizing treatment delivery time for deep-inspiration breath hold (DIBH) radiotherapy in left-sided breast cancer…”
Get full text

Inter-fraction heart displacement during voluntary deep inspiration breath hold radiation therapy without visual feedback measured by daily CBCT by Benkhaled, Sofian, Gomes da Silveira Cauduro, Carolina, Jullian, Nicolas, Desmet, Antoine, Rodriguez, Diana, Jourani, Younes, Van Gestel, Dirk, De Caluwé, Alex

“…Purpose/ObjectiveDeep Inspiration Breath Hold (DIBH) is now considered as the standard of care for many breast cancer patients. However, there are still…”
Get full text

Radiation therapy for young women with early breast cancer: Current state of the art by Meattini, Icro, Lambertini, Matteo, Desideri, Isacco, De Caluwé, Alex, Kaidar-Person, Orit, Livi, Lorenzo

“…[Display omitted] •Additional attention to the local treatment of breast cancer arising in young women should be given.•Young patients seem to receive the…”
Get full text

Predictive Biomarkers for Response to Immunotherapy in Triple Negative Breast Cancer: Promises and Challenges by Wang, Xiaoxiao, Collet, Laetitia, Rediti, Mattia, Debien, Véronique, De Caluwé, Alex, Venet, David, Romano, Emanuela, Rothé, Françoise, Sotiriou, Christos, Buisseret, Laurence

“…Triple negative breast cancer (TNBC) is a highly heterogeneous disease with a poor prognosis and a paucity of therapeutic options. In recent years,…”
Get full text

Dose-response in choroidal melanoma by De Caluwé, Alex, Termote, Karolien, Van Gestel, Dirk, Van Limbergen, Erik

“…In choroidal melanoma the radiation threshold dose for local control remains largely unknown. The present study examined a group of patients that received a…”
Get full text

Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results of the phase II PRIMMO study by De Jaeghere, Emiel A., Tuyaerts, Sandra, Van Nuffel, An M. T., Belmans, Ann, Bogaerts, Kris, Baiden-Amissah, Regina, Lippens, Lien, Vuylsteke, Peter, Henry, Stéphanie, Trinh, Xuan Bich, van Dam, Peter A., Aspeslagh, Sandrine, De Caluwé, Alex, Naert, Eline, Lambrechts, Diether, Hendrix, An, De Wever, Olivier, Van de Vijver, Koen K., Amant, Frédéric, Vandecasteele, Katrien, Denys, Hannelore G.

“…A phase II study (PRIMMO) of patients with pretreated persistent/recurrent/metastatic cervical or endometrial cancer is presented. Patients received an…”
Get full text

The incidence of symptomatic brain metastases from extra-pulmonary small cell carcinoma: Is there a role for prophylactic cranial irradiation in a clinically relevant population cohort? by De Caluwé, Alex, Bowering, Gale, Nichol, Alan, Hsu, Fred

“…To examine the incidence and outcomes of patients with brain metastases from extra-pulmonary small cell carcinoma (EPSCC) and assess the indication for…”
Get full text

Boost modalities in cervical cancer: dosimetric comparison between intracavitary BT vs. intracavitary + interstitial BT vs. SBRT by Benkhaled, Sofian, Diakité, Kadiatou, Jullian, Nicolas, Poeta, Sara, Vandekerkhove, Christophe, Van Houtte, Paul, Van Gestel, Dirk, De Caluwé, Alex

“…This study compares the dosimetric plans of three distinct boost modalities in cervical cancer (CC): intracavitary (IC) with tandem/ovoids brachytherapy (BT),…”
Get full text

Post-Neoadjuvant Treatment Strategies for Patients with Early Breast Cancer by Agostinetto, Elisa, Jacobs, Flavia, Debien, Véronique, De Caluwé, Alex, Pop, Catalin-Florin, Catteau, Xavier, Aftimos, Philippe, de Azambuja, Evandro, Buisseret, Laurence

“…Pre-surgical treatments in patients with early breast cancer allows a direct estimation of treatment efficacy, by comparing the tumor and the treatment…”
Get full text

EGFR MUTATION STATUS ON BRAIN METASTASES FROM NON-SMALL CELL LUNG CANCER by Hsu, Fred, De Caluwe, Alex, Anderson, David, Nichol, Alan, Toriumi, Ted, Ho, Cheryl

“…Highlights • A higher incidence of brain metastases with EGFR mutation positive lung cancer. • Age and EGFR mutation status are risk factors for developing…”
Get full text

Intraoperative electron radiotherapy in early invasive ductal breast cancer: 6-year median follow-up results of a prospective monocentric registry by Philippson, Catherine, Larsen, Samuel, Simon, Stéphane, Vandekerkhove, Christophe, De Caluwe, Alex, Van Gestel, Dirk, Chintinne, Marie, Veys, Isabelle, De Neubourg, Filip, Noterman, Danièle, Roman, Mirela, Nogaret, Jean-Marie, Desmet, Antoine

“…Background Intraoperative electron radiotherapy (IOERT) can be used to treat early breast cancer during the conservative surgery thus enabling shorter overall…”
Get full text

Automated segmentation in planning-CT for breast cancer radiotherapy: A review of recent advances by Smine, Zineb, Poeta, Sara, De Caluwé, Alex, Desmet, Antoine, Garibaldi, Cristina, Brou Boni, Kevin, Levillain, Hugo, Van Gestel, Dirk, Reynaert, Nick, Dhont, Jennifer

“…•Literature review of recent auto-contouring methods in breast cancer radiotherapy.•Auto-contouring of most organs-at-risk and the breast are clinically…”
Get full text

First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial by De Caluwe, Alex, Romano, Emanuela, Poortmans, Philip, Gombos, Andrea, Agostinetto, Elisa, Marta, Guilherme Nader, Denis, Zoe, Drisis, Stylianos, Vandekerkhove, Christophe, Desmet, Antoine, Philippson, Catherine, Craciun, Ligia, Veys, Isabelle, Larsimont, Denis, Paesmans, Marianne, Van Gestel, Dirk, Salgado, Roberto, Sotiriou, Christos, Piccart-Gebhart, Martine, Ignatiadis, Michail, Buisseret, Laurence

“…BackgroundLuminal B breast cancer (BC) presents a worse prognosis when compared with luminal A BC and exhibits a lower sensitivity to chemotherapy and a lower…”
Get full text

Associations of the gut microbiome with outcomes in cervical and endometrial cancer patients treated with pembrolizumab: Insights from the phase II PRIMMO trial by De Jaeghere, Emiel A., Hamerlinck, Hannelore, Tuyaerts, Sandra, Lippens, Lien, Van Nuffel, An M.T., Baiden-Amissah, Regina, Vuylsteke, Peter, Henry, Stéphanie, Trinh, Xuan Bich, van Dam, Peter A., Aspeslagh, Sandrine, De Caluwé, Alex, Naert, Eline, Lambrechts, Diether, Hendrix, An, De Wever, Olivier, Van de Vijver, Koen K., Amant, Frédéric, Vandecasteele, Katrien, Verhasselt, Bruno, Denys, Hannelore G.

“…The phase II PRIMMO trial investigated a pembrolizumab-based regimen in patients with recurrent and/or metastatic cervical (CC) or endometrial (EC) carcinoma…”
Get full text

Designing clinical trials based on modern imaging and metastasis-directed treatments in patients with oligometastatic breast cancer: a consensus recommendation from the EORTC Imaging and Breast Cancer Groups by Pasquier, David, Bidaut, Luc, Oprea-Lager, Daniela Elena, Desouza, Nandita, Krug, David, Collette, Laurence, Kunz, Wolfgang, Belkacemi, Yazid, Bau, Maria Grazia, Caramella, Caroline, de Geus-Oei, Lioe-Fee, de Caluwé, Alex, Deroose, Christophe, Gheysens, Olivier, Herrmann, Ken, Kindts, Isabelle, Kontos, Michalis, Kümmel, Sherko, Linderholm, Barbro, Lopci, Egesta, Meattini, Icro, Smeets, Ann, Kaidar-Person, Orit, Poortmans, Philip, Tsoutsou, Pelagia, Hajjaji, Nawale, Russell, Nicola, Senkus, Elżbieta, Talbot, Jean-Noël, Umutlu, Lale, Vandecaveye, Vincent, Verhoeff, Joost, van Oordt, Willemien Menke-van der Houven, Zacho, Helle, Cardoso, Fatima, Fournier, Laure, van Duijnhoven, Frederieke, Lecouvet, Frédéric

Get full text