Search Results - "de Bus, Liesbet"

Characteristics of Sepsis-2 septic shock patients failing to satisfy the Sepsis-3 septic shock definition: an analysis of real-time collected data by Vermassen, Joris, Decruyenaere, Johan, De Bus, Liesbet, Depuydt, Pieter, Colpaert, Kirsten

“…Background Baseline characteristics and disease severity of patients with septic shock according to the new Sepsis-3 definition may differ from patients that…”
Get full text

A complete and multifaceted overview of antibiotic use and infection diagnosis in the intensive care unit: results from a prospective four-year registration by De Bus, Liesbet, Gadeyne, Bram, Steen, Johan, Boelens, Jerina, Claeys, Geert, Benoit, Dominique, De Waele, Jan, Decruyenaere, Johan, Depuydt, Pieter

“…Preparing an antibiotic stewardship program requires detailed information on overall antibiotic use, prescription indication and ecology. However, longitudinal…”
Get full text

Impact of de-escalation of beta-lactam antibiotics on the emergence of antibiotic resistance in ICU patients: a retrospective observational study by De Bus, Liesbet, Denys, Wouter, Catteeuw, Julie, Gadeyne, Bram, Vermeulen, Karel, Boelens, Jerina, Claeys, Geert, De Waele, Jan J., Decruyenaere, Johan, Depuydt, Pieter O.

“…Purpose Antibiotic de-escalation is promoted to limit prolonged exposure to broad-spectrum antibiotics, but proof that it prevents the emergence of resistance…”
Get full text

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis by Van Wyngene, Lise, Vanderhaeghen, Tineke, Timmermans, Steven, Vandewalle, Jolien, Van Looveren, Kelly, Souffriau, Jolien, Wallaeys, Charlotte, Eggermont, Melanie, Ernst, Sam, Van Hamme, Evelien, Gonçalves, Amanda, Eelen, Guy, Remmerie, Anneleen, Scott, Charlotte L, Rombouts, Caroline, Vanhaecke, Lynn, De Bus, Liesbet, Decruyenaere, Johan, Carmeliet, Peter, Libert, Claude

“…Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on…”
Get full text

Assessment of microbial diversity in biofilms recovered from endotracheal tubes using culture dependent and independent approaches by Vandecandelaere, Ilse, Matthijs, Nele, Van Nieuwerburgh, Filip, Deforce, Dieter, Vosters, Peter, De Bus, Liesbet, Nelis, Hans J, Depuydt, Pieter, Coenye, Tom

“…Ventilator-associated pneumonia (VAP) is a common nosocomial infection in mechanically ventilated patients. Biofilm formation is one of the mechanisms through…”
Get full text

Hospital-acquired bloodstream infections in critically ill cirrhotic patients: a post-hoc analysis of the EUROBACT-2 international cohort study by Wozniak, Hannah, Tabah, Alexis, Barbier, François, Ruckly, Stéphane, Loiodice, Ambre, Akova, Murat, Leone, Marc, Conway Morris, Andrew, Bassetti, Matteo, Arvaniti, Kostoula, Ferrer, Ricard, de Bus, Liesbet, Paiva, Jose Artur, Bracht, Hendrik, Mikstacki, Adam, Alsisi, Adel, Valeanu, Liana, Prazak, Josef, Timsit, Jean-François, Buetti, Niccolò

“…Background Hospital-acquired bloodstream infections are common in the intensive care unit (ICU) and have a high mortality rate. Patients with cirrhosis are…”
Get full text

Pathogen-based target attainment of optimized continuous infusion dosing regimens of piperacillin-tazobactam and meropenem in surgical ICU patients: a prospective single center observational study by De Corte, Thomas, Verhaeghe, Jarne, Dhaese, Sofie, Van Vooren, Sarah, Boelens, Jerina, G. Verstraete, Alain, Stove, Veronique, Ongenae, Femke, De Bus, Liesbet, Depuydt, Pieter, Van Hoecke, Sofie, J. De Waele, Jan

“…Background Several studies have indicated that commonly used piperacillin-tazobactam (TZP) and meropenem (MEM) dosing regimens lead to suboptimal plasma…”
Get full text

No improvement in mortality among critically ill patients with carbapenems as initial empirical therapy and more detection of multi-drug resistant pathogens associated with longer use: a post hoc analysis of a prospective cohort study by Ishii, Junki, Nishikimi, Mitsuaki, De Bus, Liesbet, De Waele, Jan, Takaba, Akihiro, Kuriyama, Akira, Kobayashi, Atsuko, Tanaka, Chie, Hashi, Hideki, Hashimoto, Hideki, Nashiki, Hiroshi, Shibata, Mami, Kanamoto, Masafumi, Inoue, Masashi, Hashimoto, Satoru, Katayama, Shinshu, Fujiwara, Shinsuke, Kameda, Shinya, Shindo, Shunsuke, Komuro, Tetsuya, Kawagishi, Toshiomi, Kawano, Yasumasa, Fujita, Yoshihito, Kida, Yoshiko, Hara, Yuya, Yoshida, Hideki, Fujitani, Shigeki, Shime, Nobuaki

“…Whether empirical therapy with carbapenems positively affects the outcomes of critically ill patients with bacterial infections remains unclear. This study…”
Get full text

Use of broad-spectrum antimicrobials for more than 72 h and the detection of multidrug-resistant bacteria in Japanese intensive care units: a multicenter retrospective cohort study by Yoshida, Hideki, Motohashi, Takako, De Bus, Liesbet, De Waele, Jan, Takaba, Akihiro, Kuriyama, Akira, Kobayashi, Atsuko, Tanaka, Chie, Hashi, Hideki, Hashimoto, Hideki, Nashiki, Hiroshi, Shibata, Mami, Kanamoto, Masafumi, Inoue, Masashi, Hashimoto, Satoru, Katayama, Shinshu, Fujiwara, Shinsuke, Kameda, Shinya, Shindo, Shunsuke, Suzuki, Taketo, Komuro, Tetsuya, Kawagishi, Toshiomi, Kawano, Yasumasa, Fujita, Yoshihito, Kida, Yoshiko, Hara, Yuya, Fujitani, Shigeki

“…Background Large multicenter studies reporting on the association between the duration of broad-spectrum antimicrobial administration and the detection of…”
Get full text

P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia by Paling, Fleur P, Wolkewitz, Martin, Depuydt, Pieter, de Bus, Liesbet, Sifakis, Frangiscos, Bonten, Marc J M, Kluytmans, Jan A J W

“…To determine the incidence of (PA) ICU pneumonia and its independent association with PA colonization at ICU admission. This was a post-hoc analysis of a…”
Get full text

Antibiotic de-escalation: finally, some action and not only words by Tabah, Alexis, De Bus, Liesbet, Leone, Marc

“…A small embedded ecological study, comparing rectal samples at the onset and end of treatment, provided encouraging, albeit not significant, results in favour…”
Get full text

Empirical antimicrobials in the intensive care unit by De Bus, Liesbet, Arvaniti, Kostoula, Sjövall, Fredrik

Get full text

When fear takes control: the multidrug resistance story during pandemics by Leone, Marc, de Bus, Liesbet, Morris, Andrew Conway

Get full text

Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis by Ballegeer, Marlies, Vandewalle, Jolien, Eggermont, Melanie, Van Isterdael, Gert, Dejager, Lien, De Bus, Liesbet, Decruyenaere, Johan, Vandenbroucke, Roosmarijn E, Libert, Claude

“…ABSTRACTSepsis in humans and experimental animals is characterized by an acute inflammatory response. glucocorticoids (GCs) are widely used for the treatment…”
Get full text

How to treat infections in a surgical intensive care unit by De Waele, Jan, De Bus, Liesbet

“…The management of infections in surgical intensive care unit patients poses specific challenges. Although the overall approach to the patient is no different…”
Get full text

Automated screening of natural language in electronic health records for the diagnosis septic shock is feasible and outperforms an approach based on explicit administrative codes by Vermassen, Joris, Colpaert, Kirsten, De Bus, Liesbet, Depuydt, Pieter, Decruyenaere, Johan

“…Identification of patients for epidemiologic research through administrative coding has important limitations. We investigated the feasibility of a search…”
Get full text

Antibiotic stewardship: do not rely on de-escalation alone by De Bus, Liesbet, Depuydt, Pieter O.

Get full text

Attributable Mortality of Ventilator-associated Pneumonia. Replicating Findings, Revisiting Methods by Steen, Johan, Vansteelandt, Stijn, De Bus, Liesbet, Depuydt, Pieter, Gadeyne, Bram, Benoit, Dominique D, Decruyenaere, Johan

“…Estimating the impact of ventilator-associated pneumonia (VAP) from routinely collected intensive care unit (ICU) data is methodologically challenging. We aim…”
Get full text

Empirical carbapenems or piperacillin/tazobactam for infections in intensive care: An international retrospective cohort study by Meier, Nick, Munch, Marie Warrer, Granholm, Anders, Perner, Anders, Hertz, Frederik Boëtius, Venkatesh, Balasubramanian, Hammond, Naomi E., Li, Qiang, De Bus, Liesbet, De Waele, Jan, Kauzonas, Evaldas, Sjövall, Fredrik, Møller, Morten Hylander, Helleberg, Marie

“…Background Critically ill patients in intensive care units (ICU) are frequently administered broad‐spectrum antibiotics (e.g., carbapenems or…”
Get full text

Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis by Steeland, Sophie, Van Ryckeghem, Sara, Vandewalle, Jolien, Ballegeer, Marlies, Van Wonterghem, Elien, Eggermont, Melanie, Decruyenaere, Johan, De Bus, Liesbet, Libert, Claude, Vandenbroucke, Roosmarijn E.

“…OBJECTIVES:Sepsis causes very high mortality and morbidity rates and remains one of the biggest medical challenges. This study investigates whether plasma…”
Get full text